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Dr. Hsu Li Yang, Dr. Tan Thuan Tong, Dr. Andrea Kwa, 08 Jan 2021
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HIV infection may take the edge off inflammatory bowel disease

08 Jan 2021

The course of inflammatory bowel disease (IBD) appears to be similar in patients with and without HIV infection, even though infected patients receive less treatments, according to a study.

A total of 195 IBD patients participated in the multicentre retrospective cohort study. Of these, 65 had HIV infection and 130 were uninfected. In the infected group, 22 patients (33.8 percent) required immunosuppressants and 31 (47.7 percent) received biologics.

Between the two patient groups, those with HIV infection had a significantly lower need for immunosuppressants (p=0.034 for Crohn’s disease [CD]; p=0.012 for ulcerative colitis [UC]) and biologics (p=0.004 for CD; p=0.008 for UC).

However, the presence of HIV infection did not alter the disease course, which was measured using a severity composite criterion, when compared against the noninfected group. The hazard ratios were 1.3 (95 percent confidence interval [CI], 0.7–2.4) for CD (p=0.45) and 1.1 (95 percent CI, 0.5–2.7) for UC (p=0.767).

The overall drug safety profiles of immunosuppressants and biologics were comparable in the infected and noninfected groups.

It is established that both IBD and HIV can modify innate and adaptive immunity in the intestinal mucosa. The present data suggest that HIV has the potential to attenuate IBD. Furthermore, the safety findings are reassuring, especially for clinicians, providing support for treating patients according to current recommendations.

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Most Read Articles
01 Dec 2020
Tetanus toxoid 5 Lf, diphtheria toxoid 2 Lf, pertussis toxoid 2.5 mcg, filamentous haemagglutinin 5 mcg, fimbriae types 2 and 3 5 mcg, pertactin 3 mcg
Dr. Hsu Li Yang, Dr. Tan Thuan Tong, Dr. Andrea Kwa, 08 Jan 2021
Antimicrobial resistance has become increasingly dire as the rapid emergence of drug resistance, especially gram-negative pathogens, has outpaced the development of new antibiotics. At a recent virtual symposium, Dr Hsu Li Yang, Vice Dean (Global Health) and Programme Leader (Infectious Diseases), NUS Saw Swee Hock School of Public Health, presented epidemiological data on multidrug-resistant (MDR) gram-negative bacteria (GNB) in Asia, while Dr Tan Thuan Tong, Head and Senior Consultant, Department of Infectious Diseases, Singapore General Hospital (SGH), focused on the role of ceftazidime-avibactam in MDR GNB infections. Dr Andrea Kwa, Assistant Director of Research, Department of Pharmacy, SGH, joined the panel in an interactive fireside chat, to discuss challenges, practical considerations, and solutions in MDR gram-negative infections. This Pfizer-sponsored symposium was chaired by Dr Ng Shin Yi, Head and Senior Consultant of Surgical Intensive Care, SGH.
Jairia Dela Cruz, 4 days ago
Spending too much time sitting cannot be good for the body, and rising to one's feet breaks up such a behaviour and yields small, but meaningful, reductions in certain cardiovascular disease (CVD) risk factors, according to the results of a meta-analysis.
4 days ago
Use of thyroid hormone therapy does not seem to protect older adults with subclinical hypothyroidism against mortality, but it appears to confer survival benefits to those aged <65 years, results of a study have shown.