Most Read Articles
Roshini Claire Anthony, 6 days ago

Beta-blockers could reduce mortality risk in patients with heart failure with reduced ejection fraction (HFrEF) and moderate or moderately-severe renal dysfunction without causing harm, according to the BB-META-HF* trial presented at ESC 2019.

6 days ago
Blood pressure (BP) in children is influenced by early-life exposure to several chemicals, built environment and meteorological factors, suggests a study.
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Short sleep duration is associated with an increased risk of myocardial infarction (MI), according to prospective observational and Mendelian randomization (MR) analyses.
Tristan Manalac, 6 days ago
The addition of ezetimibe improves statin treatment in acute coronary syndrome (ACS) patients with dyslipidaemia and low eicosapentaenoic acid-to-arachidonic acid (EPA/AA) ratio, resulting in a lowered risk of cardiovascular events compared to monotherapy, according to a study presented at the recently concluded 2019 Congress of the European Society of Cardiology (ESC 2019) held in Paris, France.

Highly physically active women at low risk of rheumatoid arthritis

11 Aug 2019

High physical activity levels reduce the risk of developing rheumatoid arthritis (RA) in women, a study has found.

The study involved 113,366 participants from the Nurses' Health Study II, among whom 506 developed RA (67.0 percent had seropositive RA) over 2,428,573 person‐years of follow‐up. Every participant completed biennial questionnaires to determine physical activity exposures and covariates.

Researchers evaluated the long‐term cumulative average number of hours spent in recreational physical activity 2–8 years prior to the RA diagnosis. This time span was chosen to reduce the potential for reverse causation bias, given that early RA affects physical activity prior to diagnosis.

Multivariable Cox regression analysis revealed that increasing cumulative average total hours of recreational physical activity had a protective association with the risk of RA. Relative to women engaging in <1 hour of physical activity per week, those who were more physically active had up to about a 30-percent lower risk of developing RA (2 to <4 hours/week: hazard ratio [HR], 0.92, 95 percent CI, 0.72–1.17; 4 to <7 hours/week: HR, 0.84, 0.63–1.12; ≥7 hours/week: HR, 0.67, 0.47–0.98; p-trend=0.02).

Body mass index mediated some of the effect of physical activity on all RA (14.0 percent; p=0.002) and on seropositive RA (20.0 percent; p=0.001), suggesting that both physical activity and weight-loss interventions could delay or even prevent the onset of seropositive RA, according to the researchers.

The present data contribute to the increasing evidence that metabolic factors play an important role in RA pathogenesis, they added.

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Most Read Articles
Roshini Claire Anthony, 6 days ago

Beta-blockers could reduce mortality risk in patients with heart failure with reduced ejection fraction (HFrEF) and moderate or moderately-severe renal dysfunction without causing harm, according to the BB-META-HF* trial presented at ESC 2019.

6 days ago
Blood pressure (BP) in children is influenced by early-life exposure to several chemicals, built environment and meteorological factors, suggests a study.
6 days ago
Short sleep duration is associated with an increased risk of myocardial infarction (MI), according to prospective observational and Mendelian randomization (MR) analyses.
Tristan Manalac, 6 days ago
The addition of ezetimibe improves statin treatment in acute coronary syndrome (ACS) patients with dyslipidaemia and low eicosapentaenoic acid-to-arachidonic acid (EPA/AA) ratio, resulting in a lowered risk of cardiovascular events compared to monotherapy, according to a study presented at the recently concluded 2019 Congress of the European Society of Cardiology (ESC 2019) held in Paris, France.