Most Read Articles
06 Sep 2019
Gastric dysplasia (GD), specifically high-grade lesions, appears to carry an elevated risk of progression to gastric adenocarcinoma (GAC), according to the results of a meta-analysis.
Roshini Claire Anthony, 4 days ago

Beta-blockers could reduce mortality risk in patients with heart failure with reduced ejection fraction (HFrEF) and moderate or moderately-severe renal dysfunction without causing harm, according to the BB-META-HF* trial presented at ESC 2019.

Stephen Padilla, 5 days ago
Implementation of the collaborative care in a rheumatoid arthritis (RA) clinic has led to improvements in nonbiologic disease-modifying antirheumatic drugs (nb-DMARDs) optimization, adherence to safety recommendations on nb-DMARD monitoring and detection of adverse drug events in RA patients, according to a Singapore study.
05 Sep 2019
Supplementation with vitamin D appears to help reduce the serum concentration of total and low-density lipoprotein cholesterol and triglyceride but not high-density lipoprotein cholesterol, suggesting its usefulness for mitigating the risk of cardiovascular disease in patients with hypercholesterolaemia, according to the results of a meta-analysis.

Highly physically active women at low risk of rheumatoid arthritis

11 Aug 2019

High physical activity levels reduce the risk of developing rheumatoid arthritis (RA) in women, a study has found.

The study involved 113,366 participants from the Nurses' Health Study II, among whom 506 developed RA (67.0 percent had seropositive RA) over 2,428,573 person‐years of follow‐up. Every participant completed biennial questionnaires to determine physical activity exposures and covariates.

Researchers evaluated the long‐term cumulative average number of hours spent in recreational physical activity 2–8 years prior to the RA diagnosis. This time span was chosen to reduce the potential for reverse causation bias, given that early RA affects physical activity prior to diagnosis.

Multivariable Cox regression analysis revealed that increasing cumulative average total hours of recreational physical activity had a protective association with the risk of RA. Relative to women engaging in <1 hour of physical activity per week, those who were more physically active had up to about a 30-percent lower risk of developing RA (2 to <4 hours/week: hazard ratio [HR], 0.92, 95 percent CI, 0.72–1.17; 4 to <7 hours/week: HR, 0.84, 0.63–1.12; ≥7 hours/week: HR, 0.67, 0.47–0.98; p-trend=0.02).

Body mass index mediated some of the effect of physical activity on all RA (14.0 percent; p=0.002) and on seropositive RA (20.0 percent; p=0.001), suggesting that both physical activity and weight-loss interventions could delay or even prevent the onset of seropositive RA, according to the researchers.

The present data contribute to the increasing evidence that metabolic factors play an important role in RA pathogenesis, they added.

Digital Edition
Asia's trusted medical magazine for healthcare professionals. Get your MIMS Doctor - Malaysia digital copy today!
Sign In To Download
Editor's Recommendations
Most Read Articles
06 Sep 2019
Gastric dysplasia (GD), specifically high-grade lesions, appears to carry an elevated risk of progression to gastric adenocarcinoma (GAC), according to the results of a meta-analysis.
Roshini Claire Anthony, 4 days ago

Beta-blockers could reduce mortality risk in patients with heart failure with reduced ejection fraction (HFrEF) and moderate or moderately-severe renal dysfunction without causing harm, according to the BB-META-HF* trial presented at ESC 2019.

Stephen Padilla, 5 days ago
Implementation of the collaborative care in a rheumatoid arthritis (RA) clinic has led to improvements in nonbiologic disease-modifying antirheumatic drugs (nb-DMARDs) optimization, adherence to safety recommendations on nb-DMARD monitoring and detection of adverse drug events in RA patients, according to a Singapore study.
05 Sep 2019
Supplementation with vitamin D appears to help reduce the serum concentration of total and low-density lipoprotein cholesterol and triglyceride but not high-density lipoprotein cholesterol, suggesting its usefulness for mitigating the risk of cardiovascular disease in patients with hypercholesterolaemia, according to the results of a meta-analysis.