Most Read Articles
Yesterday
Routinely used for treating cardiovascular diseases, statins have been shown to benefit other conditions, and new evidence suggests that using the drug at high intensity reduces the risk of hip or knee replacement, an effect that may be specific to rheumatoid arthritis.
Pearl Toh, 29 Jun 2020
Having migraine during midlife appears to be associated with a higher risk of developing dementia in later life, according to a large population-based longitudinal Danish study presented at the AHS* 2020 Virtual Meeting, indicating that migraine may be a risk factor for dementia.
30 Jun 2020
Patients with psoriatic arthritis (PsA) often suffer from liver abnormalities, which are associated with higher body mass index (BMI), daily consumption of alcohol, more severe disease, and some therapies, according to a recent study.
Christina Lau, 5 days ago

Pembrolizumab in combination with chemotherapy significantly improves progression-free survival (PFS) vs chemotherapy alone in patients with previously untreated, locally recurrent inoperable or metastatic triple-negative breast cancer (TNBC), results of the KEYNOTE-355 study have shown.

Higher TSH not linked to thyroid cancer risk in presence of thyroid autoimmunity

17 Jun 2020

A recent study has revealed that concentrations of thyroid-stimulating hormone (TSH) do not correlate with the risk of developing differentiated thyroid cancer (DTC) in the presence of thyroid autoimmunity, even if this appears to be the case for other patients.

The authors analysed a prospectively collected database of patients referred for thyroid surgery at two tertiary care referral centres in Greece and the US. Data for preoperative TSH, postoperative pathology, and thyroid peroxidase (TPO) antibodies titres were collected.

Patients were further categorized into two: those with autoimmune thyroid disease (AITD; ie, lymphocytic thyroiditis) and non-AITD. Those with Graves’ disease, abnormal TSH (<0.40 or >4.50 mIU/mL), or recent use of levothyroxine were excluded. The authors then used the Mann-Whitney test to compare the serum TSH among different groups.

Of the 3,973 patients screened, 1,357 were excluded. After all exclusions, data from 1,731 non-AITD and 329 AITD patients were analysed. TSH concentrations were higher among AITD than non-AITD patients (2.09 vs 1.48; p<0.0001).

TSH values were higher in DTC compared with benign histology only in non-AITD patients (1.65 vs 1.40; p<0.0001). Of note, progressively higher TSH appeared to lead to a higher incidence of DTC in non-AITD individuals (p<0.0001). In AITD patients, TSH was comparable between groups with and without DTC (2.02 vs 2.14; p=0.21).

“Higher-but-within-normal thyrotropin is associated with higher risk for DTC in surgical series,” the authors said. “Our recent clinical observations suggest that this is not the case in the presence of AITD.”

Digital Edition
Asia's trusted medical magazine for healthcare professionals. Get your MIMS Endocrinology - Malaysia digital copy today!
Sign In To Download
Editor's Recommendations
Most Read Articles
Yesterday
Routinely used for treating cardiovascular diseases, statins have been shown to benefit other conditions, and new evidence suggests that using the drug at high intensity reduces the risk of hip or knee replacement, an effect that may be specific to rheumatoid arthritis.
Pearl Toh, 29 Jun 2020
Having migraine during midlife appears to be associated with a higher risk of developing dementia in later life, according to a large population-based longitudinal Danish study presented at the AHS* 2020 Virtual Meeting, indicating that migraine may be a risk factor for dementia.
30 Jun 2020
Patients with psoriatic arthritis (PsA) often suffer from liver abnormalities, which are associated with higher body mass index (BMI), daily consumption of alcohol, more severe disease, and some therapies, according to a recent study.
Christina Lau, 5 days ago

Pembrolizumab in combination with chemotherapy significantly improves progression-free survival (PFS) vs chemotherapy alone in patients with previously untreated, locally recurrent inoperable or metastatic triple-negative breast cancer (TNBC), results of the KEYNOTE-355 study have shown.