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14 Aug 2018
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Although many patients with atopic dermatitis (AD) use antihistamines, no high-level evidence exists to prove that nonsedating antihistamines reduce itch in patients with AD or provide benefit in controlling AD symptoms, except perhaps sleep and AD comorbidities such as allergic rhinitis, according to a study.

Higher total homocysteine during convalescent phase ups risk of recurrent ischaemic stroke

17 May 2018

The risk of recurrent ischaemic stroke is higher in patients with elevated total homocysteine (tHcy) levels during the convalescent phase of acute stroke, a recent study has found.

Researchers measured tHcy levels during acute ischaemia in 2,800 patients, of whom 2,587 had ischaemic stroke (mean age 60.7±10.5 years; 70.0 percent male) and 213 had haemorrhagic stroke (mean age 57.2±10.0 years; 63.4 percent male). THcy levels were measured again 3 months after. Cox proportional hazards regression analysis was performed to determine the relationship between tHcy and recurrent stroke.

Over a median follow-up period of 18 months, 7.9 percent (n=220) of patients had recurrent ischaemic stroke. This risk was highest in patients who belonged to the highest vs lowest quartile of tHcy levels 3 months after acute stroke (adjusted hazard ratio [HR], 1.76; 95 percent CI, 1.11–3.08; p<0.05).

Those in the third vs first quartile of tHcy concentrations at 3 months also had a significantly higher risk of ischaemic stroke reoccurrence (adjusted HR, 1.51; 1.04–2.19; p<0.05). Analysis by type of ischaemia showed that this trend was especially true for patients with large artery atherosclerosis (fourth quartile: adjusted HR, 2.62; 1.29–5.30; third quartile: adjusted HR, 2.11; 1.04–4.28; p<0.05 for both).

In comparison, the fourth (HR, 1.31; 0.91–1.91) and third (HR, 1.28; 0.89–1.86) quartiles of tHcy levels within 3 days of acute stroke did not show heightened risks of recurrent ischaemic stroke.

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Most Read Articles
14 Aug 2018
Patients with coronary artery disease (CAD) treated in a poor Southeast Asian setting appear to have far too high short-term and medium-term mortality rates, according to a study.
2 days ago
Despite the absence of a substance use problem, regular cannabis use is associated with psychosocial impairment among adolescents and young adults, a study suggests. On the other hand, regular users with cannabis use disorder appear to exhibit high psychiatric comorbidity and more severe psychosocial impairment.
4 days ago
Heeding the advice to eat more vegetables has led to an increase in consumption above the Australian Dietary recommendation of ~375 g/day among overweight participants, a recent study has shown. Tomatoes are a common choice regardless of the time of year, but selections change over time.
21 Jul 2018
Although many patients with atopic dermatitis (AD) use antihistamines, no high-level evidence exists to prove that nonsedating antihistamines reduce itch in patients with AD or provide benefit in controlling AD symptoms, except perhaps sleep and AD comorbidities such as allergic rhinitis, according to a study.