Higher stroke risk in CKD, ESRD patients
The risk of stroke and subsequent mortality is significantly elevated in patients with chronic kidney disease (CKD) and end-stage renal disease (ESRD), a recent study has shown.
The study included 1,378 ESRD patients, 5,512 CKD patients and 11,024 controls, with incident stroke events as the primary outcome. Relative to controls, the risk of stroke was significantly elevated in ESRD patients (hazard ratio [HR], 2.39; 95 percent CI, 1.98–2.87). CKD patients also had significantly higher risks of stroke compared with controls (HR, 1.49; 1.32–1.68).
These associations remained significant even when analyses were stratified according to gender, age and comorbidities.
After propensity-score matching, the risk of stroke remained significantly elevated in both CKD (HR, 1.51; 1.24–1.85) and ESRD (HR, 2.08; 1.32–3.26) patients compared with controls.
In patients with CKD, the risk of 30-day poststroke mortality was also significantly elevated than in controls (rate ratio [RR], 1.44; 1.33–1.56). Mortality risk was likewise higher in hospitalized stroke patients with ESRD (RR, 2.62; 2.43–2.82).
The association of poststroke mortality with both diseases remained significant even when the analyses were stratified according to age and sex.
In terms of baseline characteristics, newly diagnosed stroke patients with ESRD were more likely to be female (p<0.0001), and have haemorrhagic stroke (p<0.0001), diabetes (p<0.0001), heart failure (p<0.0001), chronic obstructive pulmonary disease (p<0.0001) and anaemia (p<0.0001).
In comparison, CKD was significantly correlated with older age (p<0.0001), other stroke subtypes (p<0.0001), mental disorder (p<0.0001) and traumatic brain injuries (p<0.0001), among others.