Most Read Articles
Pearl Toh, 07 Aug 2018
A home-based, self-applied wearable electrocardiogram (ECG) patch facilitates diagnosis of atrial fibrillation (AF) among high-risk individuals, according to the mSToPS* trial.
Roshini Claire Anthony, Yesterday

A genotype-guided approach to warfarin dosing may result in fewer dose adjustments in Asian patients, according to a study from Singapore.

4 days ago

Fungal microbiome, also called the mycobiome, appears to be highly variable in patients with well-characterized fungal diseases, a recent study has shown. Moreover, severe asthmatics have the highest fungal loads, along with those receiving steroid and antifungal therapy.

Tristan Manalac, 3 days ago
The risk of complicated appendicitis is lower in children with IgE-mediated allergy, according to a recent study.

Higher stroke risk in CKD, ESRD patients

16 Jan 2018

The risk of stroke and subsequent mortality is significantly elevated in patients with chronic kidney disease (CKD) and end-stage renal disease (ESRD), a recent study has shown.

The study included 1,378 ESRD patients, 5,512 CKD patients and 11,024 controls, with incident stroke events as the primary outcome. Relative to controls, the risk of stroke was significantly elevated in ESRD patients (hazard ratio [HR], 2.39; 95 percent CI, 1.98–2.87). CKD patients also had significantly higher risks of stroke compared with controls (HR, 1.49; 1.32–1.68).

These associations remained significant even when analyses were stratified according to gender, age and comorbidities.

After propensity-score matching, the risk of stroke remained significantly elevated in both CKD (HR, 1.51; 1.24–1.85) and ESRD (HR, 2.08; 1.32–3.26) patients compared with controls.

In patients with CKD, the risk of 30-day poststroke mortality was also significantly elevated than in controls (rate ratio [RR], 1.44; 1.33–1.56). Mortality risk was likewise higher in hospitalized stroke patients with ESRD (RR, 2.62; 2.43–2.82).

The association of poststroke mortality with both diseases remained significant even when the analyses were stratified according to age and sex.

In terms of baseline characteristics, newly diagnosed stroke patients with ESRD were more likely to be female (p<0.0001), and have haemorrhagic stroke (p<0.0001), diabetes (p<0.0001), heart failure (p<0.0001), chronic obstructive pulmonary disease (p<0.0001) and anaemia (p<0.0001).

In comparison, CKD was significantly correlated with older age (p<0.0001), other stroke subtypes (p<0.0001), mental disorder (p<0.0001) and traumatic brain injuries (p<0.0001), among others.

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Most Read Articles
Pearl Toh, 07 Aug 2018
A home-based, self-applied wearable electrocardiogram (ECG) patch facilitates diagnosis of atrial fibrillation (AF) among high-risk individuals, according to the mSToPS* trial.
Roshini Claire Anthony, Yesterday

A genotype-guided approach to warfarin dosing may result in fewer dose adjustments in Asian patients, according to a study from Singapore.

4 days ago

Fungal microbiome, also called the mycobiome, appears to be highly variable in patients with well-characterized fungal diseases, a recent study has shown. Moreover, severe asthmatics have the highest fungal loads, along with those receiving steroid and antifungal therapy.

Tristan Manalac, 3 days ago
The risk of complicated appendicitis is lower in children with IgE-mediated allergy, according to a recent study.