Most Read Articles
Pearl Toh, 24 Nov 2016
New treatments such as pirfenidone and nintedanib slow lung function decline and progression of idiopathic pulmonary fibrosis (IPF), although response to treatment can vary dramatically among patients, according to a presentation at the 21st Congress of the Asian Pacific Society of Respirology (APSR 2016) held in Bangkok, Thailand.
16 Oct 2016
Irritable bowel syndrome and asthma share a bidirectional association, a new study reports. Further, atopy potentially plays a role in the underlying mechanisms of this association.
Audrey Abella, 09 May 2018
The potent and highly selective RET* inhibitor BLU-667 was well-tolerated and exhibited promising clinical activity among patients with advanced, RET-altered solid cancers that progressed despite multikinase inhibitor therapy, according to data presented at AACR 2018.

Higher mortality, improved disease severity in children on noninvasive ventilation

03 Feb 2018
Children are fully able to experience and display the appropriate response to pain, which may highlight the need for appropriate analgesia or anaesthesia in paediatric patients.

There appears to be no increase in complication burden and breathing abnormality severity in children receiving noninvasive ventilation (NIV), reflecting the increasing prevalence of its use, a recent study has shown.

Researchers performed a retrospective cohort study of 622 children starting long-term NIV and found that between 2005 and 2008, the rate of NIV use increased from 1.65 to 8.01 per 100,000 children. This was followed by periods of stability at 7.9 per 100,000 children initiating NIV from 2008–2011 and 2011–2014 (p<0.001 for trend).

Discontinuation of NIV due to improvements in underlying conditions increased significantly from 84.2 per 1,000 children in 2005–2008 to 123.2 per 1,000 children in 2008–2011 and 292.1 per 1,000 children in 2011–2014 (p<0.001 for trend).

The same increasing trend was observed for discontinuations due to family decisions (74.1 per 1,000 children in 2005–2008 to 245.4 per 1,000 children in 2011–2014; p<0.001) and transfer to adult services (74.1 per 1,000 children in 2005–2008 to 105.2 per 1,000 cases in 2011–2014; p<0.001).

However, mortality rates also significantly grew. From 3.4 deaths per 1,000 children in 2005–2008, the mortality increased to 39.2 per 1,000 children in 2008–2011 and 142.1 per 1,000 children in 2011–2014 (p<0.001 for trend). Age at death remained statistically constant throughout the study period.

Subgroup analysis showed that particular diagnoses were more associated with lower survival than others. For instance, patients with central nervous system (CNS) and cardiorespiratory conditions tended to have poorer survival than those with upper airway and musculoskeletal and neuromuscular disorders. Mortality rates grew over time for CNS conditions and remained constant for the others.

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Most Read Articles
Pearl Toh, 24 Nov 2016
New treatments such as pirfenidone and nintedanib slow lung function decline and progression of idiopathic pulmonary fibrosis (IPF), although response to treatment can vary dramatically among patients, according to a presentation at the 21st Congress of the Asian Pacific Society of Respirology (APSR 2016) held in Bangkok, Thailand.
16 Oct 2016
Irritable bowel syndrome and asthma share a bidirectional association, a new study reports. Further, atopy potentially plays a role in the underlying mechanisms of this association.
Audrey Abella, 09 May 2018
The potent and highly selective RET* inhibitor BLU-667 was well-tolerated and exhibited promising clinical activity among patients with advanced, RET-altered solid cancers that progressed despite multikinase inhibitor therapy, according to data presented at AACR 2018.