Most Read Articles
Elvira Manzano, 02 Oct 2018
Triple therapy with budesonide, glycopyrrolate, and formoterol in one metered dose inhaler (BGF MDI) appears effective and is well-tolerated in patients with symptomatic moderate-to-severe chronic obstructive pulmonary disease (COPD) irrespective of exacerbation history, the multicentre, phase III KRONOS* trial has shown.
Dr. Fanny Wai-San Ko, Dr. Wing-Ho Yip, 15 Aug 2018
Although a majority of patients can achieve good asthma control with the use of inhaled corticosteroid (ICS) and bronchodilators, some patients’ asthma remain uncontrolled despite the use of these medications.
Stephen Padilla, 14 Jan 2019
Overall, the risk of lung cancer is higher in former and current smokers with higher concentrations of high sensitivity C-reactive protein (hsCRP), according to a study. Additionally, circulating hsCRP is not associated with the risk of lung adenocarcinoma and may reflect a prediagnostic disease state rather than a causal risk for lung cancer.
20 Feb 2018
Dr Michael Lim, consultant of the Division of Paediatric Pulmonary and Sleep in National University Hospital, Singapore, shares his insights with Pearl Toh on diagnosing and managing paediatric asthma in the primary care setting.

Higher mortality, improved disease severity in children on noninvasive ventilation

03 Feb 2018
Children are fully able to experience and display the appropriate response to pain, which may highlight the need for appropriate analgesia or anaesthesia in paediatric patients.

There appears to be no increase in complication burden and breathing abnormality severity in children receiving noninvasive ventilation (NIV), reflecting the increasing prevalence of its use, a recent study has shown.

Researchers performed a retrospective cohort study of 622 children starting long-term NIV and found that between 2005 and 2008, the rate of NIV use increased from 1.65 to 8.01 per 100,000 children. This was followed by periods of stability at 7.9 per 100,000 children initiating NIV from 2008–2011 and 2011–2014 (p<0.001 for trend).

Discontinuation of NIV due to improvements in underlying conditions increased significantly from 84.2 per 1,000 children in 2005–2008 to 123.2 per 1,000 children in 2008–2011 and 292.1 per 1,000 children in 2011–2014 (p<0.001 for trend).

The same increasing trend was observed for discontinuations due to family decisions (74.1 per 1,000 children in 2005–2008 to 245.4 per 1,000 children in 2011–2014; p<0.001) and transfer to adult services (74.1 per 1,000 children in 2005–2008 to 105.2 per 1,000 cases in 2011–2014; p<0.001).

However, mortality rates also significantly grew. From 3.4 deaths per 1,000 children in 2005–2008, the mortality increased to 39.2 per 1,000 children in 2008–2011 and 142.1 per 1,000 children in 2011–2014 (p<0.001 for trend). Age at death remained statistically constant throughout the study period.

Subgroup analysis showed that particular diagnoses were more associated with lower survival than others. For instance, patients with central nervous system (CNS) and cardiorespiratory conditions tended to have poorer survival than those with upper airway and musculoskeletal and neuromuscular disorders. Mortality rates grew over time for CNS conditions and remained constant for the others.

Digital Edition
Asia's trusted medical magazine for healthcare professionals. Get your MIMS Respirology - Malaysia digital copy today!
Sign In To Download
Editor's Recommendations
Most Read Articles
Elvira Manzano, 02 Oct 2018
Triple therapy with budesonide, glycopyrrolate, and formoterol in one metered dose inhaler (BGF MDI) appears effective and is well-tolerated in patients with symptomatic moderate-to-severe chronic obstructive pulmonary disease (COPD) irrespective of exacerbation history, the multicentre, phase III KRONOS* trial has shown.
Dr. Fanny Wai-San Ko, Dr. Wing-Ho Yip, 15 Aug 2018
Although a majority of patients can achieve good asthma control with the use of inhaled corticosteroid (ICS) and bronchodilators, some patients’ asthma remain uncontrolled despite the use of these medications.
Stephen Padilla, 14 Jan 2019
Overall, the risk of lung cancer is higher in former and current smokers with higher concentrations of high sensitivity C-reactive protein (hsCRP), according to a study. Additionally, circulating hsCRP is not associated with the risk of lung adenocarcinoma and may reflect a prediagnostic disease state rather than a causal risk for lung cancer.
20 Feb 2018
Dr Michael Lim, consultant of the Division of Paediatric Pulmonary and Sleep in National University Hospital, Singapore, shares his insights with Pearl Toh on diagnosing and managing paediatric asthma in the primary care setting.