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Pearl Toh, 26 Nov 2020
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Higher income linked to better physical functioning in SLE patients

17 Jul 2020

A higher income in relation to the poverty threshold leads to better physical functioning (PF) across multiple domains in patients with systemic lupus erythematosus, according to a study.

The authors used cross-sectional data on 744 participants from Georgians Organized Against Lupus (GOAL) for the primary analyses and data on 56 participants from a nested pilot study for the secondary analyses.

Multivariable linear regression was applied in the primary analyses to estimate the association between poverty income ratio (PIR; categorized as <1.00, 1.00–1.99, 2.00–3.99, and ≥4.00; lower PIR indicate higher poverty) and PF (scaled subscore from the Medical Outcomes Study Short Form–12 survey; range 0–100; higher scores indicate better functioning).

In secondary analyses, complementary measures of PF were summarized as means or percentages by PRI (categorized as <1.00, 1.00–1.99, and ≥2.00).

Of the participants (mean age, 48.0 years; 6.7 percent male; 80.9 percent black), 37.5 percent had PIR of <1.00, while 21.0 percent, 29.6 percent, and 12.0 percent had PIR of 1.00–1.99, 2.00–3.99, and ≥4.00, respectively.

Overall, the mean PF score was 45.8. In particular, PF score was 36.2 for PIR of <1.00, 40.7 for PIR of 1.00–1.00, 55.5 for PIR of 2.00–3.99, and 61.2 for PIR of ≥4.00. The association between greater PIR and higher PF scores (2.00–3.99 vs 1.00–1.99: β, 10.9, 95 percent confidence interval [CI], 3.3–18.6; ≥4.00 vs 1.00–1.99: β, 16.2, 95 percent CI, 6.4–26.0) persisted after adjustments.

Secondary analyses also showed that higher PIR correlated with higher scores for objective physical performance.

Further research into multicomponent functional assessments is warranted to develop individual treatment plans and potentially improve socioeconomic disparities in outcomes, the authors said.

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Most Read Articles
4 days ago
Among postmenopausal women, short sleep duration and depression contribute to increased fall accidents, as reported in a study.
01 Dec 2020
Tetanus toxoid 5 Lf, diphtheria toxoid 2 Lf, pertussis toxoid 2.5 mcg, filamentous haemagglutinin 5 mcg, fimbriae types 2 and 3 5 mcg, pertactin 3 mcg
Dr. Hsu Li Yang, Dr. Tan Thuan Tong, Dr. Andrea Kwa, 08 Jan 2021
Antimicrobial resistance has become increasingly dire as the rapid emergence of drug resistance, especially gram-negative pathogens, has outpaced the development of new antibiotics. At a recent virtual symposium, Dr Hsu Li Yang, Vice Dean (Global Health) and Programme Leader (Infectious Diseases), NUS Saw Swee Hock School of Public Health, presented epidemiological data on multidrug-resistant (MDR) gram-negative bacteria (GNB) in Asia, while Dr Tan Thuan Tong, Head and Senior Consultant, Department of Infectious Diseases, Singapore General Hospital (SGH), focused on the role of ceftazidime-avibactam in MDR GNB infections. Dr Andrea Kwa, Assistant Director of Research, Department of Pharmacy, SGH, joined the panel in an interactive fireside chat, to discuss challenges, practical considerations, and solutions in MDR gram-negative infections. This Pfizer-sponsored symposium was chaired by Dr Ng Shin Yi, Head and Senior Consultant of Surgical Intensive Care, SGH.
Pearl Toh, 26 Nov 2020
Inhaled corticosteroid (ICS) should be the mainstay of long-term asthma management — such is the key message of the latest Singapore ACE* Clinical Guidance (ACG) for asthma, released in October 2020.