Most Read Articles
05 Feb 2021

Primary immunodeficiency disease (PIDD) and allergies are two groups of conditions related to the immune system. However, they are uniquely different in terms of symptoms and treatment.

Pearl Toh, 26 Nov 2020
Inhaled corticosteroid (ICS) should be the mainstay of long-term asthma management — such is the key message of the latest Singapore ACE* Clinical Guidance (ACG) for asthma, released in October 2020.
Roshini Claire Anthony, 26 Feb 2021

Critical or severe COVID-19 disease could raise the risk of negative perinatal outcomes in pregnant women, according to an observational study from the US.

Stephen Padilla, 22 Feb 2021
Treatment with intravenous (IV) dexamethasone for 10 days significantly reduces duration of mechanical ventilation at 28 days and 60-day mortality in patients with established moderate-to-severe acute respiratory disease syndrome (ARDS) compared with no dexamethasone, results of the DEXA-ARDS trial have shown.

Higher exercise SBP response linked to incident depressive symptoms

21 Feb 2021

Increased exercise systolic blood pressure (SBP) response may predict the incidence of clinically relevant depressive symptoms, suggests a recent study.

“An exaggerated exercise SBP, which is potentially modifiable, may be associated with incident depressive symptoms via an increased pulsatile pressure load on the brain,” the investigators said. “However, the association between exaggerated exercise SBP and incident depressive symptoms is unknown.”

To determine whether exaggerated exercise SBP was associated with a higher risk of depressive symptoms over time, longitudinal data from the population-based Maastricht Study, with only individuals free of depressive symptoms at baseline included (n=2,121; mean age, 59.5 years; 51.3 percent men) were analysed.

The investigators measured exercise SBP at baseline with a submaximal exercise cycle test and calculated a composite score of exercise SBP based on four standardized exercise SBP measures: SBP at moderate workload, SBP at peak exercise, SBP change per minute during exercise, and SBP 4 min after exercise. Finally, they determined clinically relevant depressive symptoms at follow-up, defined as a Patient Health Questionnaire score of at least 10.

Of the participants, 175 (8.3 percent) demonstrated incident clinically relevant depressive symptoms after a mean follow-up of 3.9 years. A 1-standard deviation higher exercise SBP composite score correlated with a higher incidence of clinically relevant depressive symptoms (hazard ratio, 1.27, 95 percent confidence interval, 1.03–1.54).

“Results were adjusted for age, sex, education level, glucose metabolism status, lifestyle, cardiovascular risk factors, resting SBP, and cardiorespiratory fitness,” the investigators noted.

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Most Read Articles
05 Feb 2021

Primary immunodeficiency disease (PIDD) and allergies are two groups of conditions related to the immune system. However, they are uniquely different in terms of symptoms and treatment.

Pearl Toh, 26 Nov 2020
Inhaled corticosteroid (ICS) should be the mainstay of long-term asthma management — such is the key message of the latest Singapore ACE* Clinical Guidance (ACG) for asthma, released in October 2020.
Roshini Claire Anthony, 26 Feb 2021

Critical or severe COVID-19 disease could raise the risk of negative perinatal outcomes in pregnant women, according to an observational study from the US.

Stephen Padilla, 22 Feb 2021
Treatment with intravenous (IV) dexamethasone for 10 days significantly reduces duration of mechanical ventilation at 28 days and 60-day mortality in patients with established moderate-to-severe acute respiratory disease syndrome (ARDS) compared with no dexamethasone, results of the DEXA-ARDS trial have shown.