Most Read Articles
Roshini Claire Anthony, 5 days ago

A genotype-guided approach to warfarin dosing may result in fewer dose adjustments in Asian patients, according to a study from Singapore.

10 Aug 2018

Fungal microbiome, also called the mycobiome, appears to be highly variable in patients with well-characterized fungal diseases, a recent study has shown. Moreover, severe asthmatics have the highest fungal loads, along with those receiving steroid and antifungal therapy.

Tristan Manalac, 6 days ago
The risk of complicated appendicitis is lower in children with IgE-mediated allergy, according to a recent study.
21 Jul 2018
Although many patients with atopic dermatitis (AD) use antihistamines, no high-level evidence exists to prove that nonsedating antihistamines reduce itch in patients with AD or provide benefit in controlling AD symptoms, except perhaps sleep and AD comorbidities such as allergic rhinitis, according to a study.

Higher adherence to topical testosterone improves clinical outcomes in men with hypogonadism

11 Feb 2018

In males with primary or secondary hypogonadism (HG), adherence to topical testosterone therapy (TTh) appears to improve total testosterone and decrease the risk of conditions associated with HG, a recent study has shown.

Researchers performed a retrospective cohort study of 3,184 adult males (mean age 49 years) with primary or secondary HG initiating topical TTh. The rate of complete adherence for 12 months was only 16.9 percent (n=538). Majority of the participants (91 percent) were prescribed topical gels.

High adherence was associated with better clinical outcomes. For instance, the composite endpoint of fatigue, osteoarthritis, insomnia, depression and erectile dysfunction was significantly lower in those adherent to the topical TTh (adjusted odds ratio [OR], 0.764; 95 percent CI, 0.617–0.947; p=0.014).

The secondary composite outcome of obesity, diabetes or metabolic syndrome was not significantly affected by adherence (adjusted OR, 0.952; 0.723–1.252; p=0.723). None of the individual composite components were also significantly correlated with adherence.

While both adherent and nonadherent males experienced increases in total testosterone levels relative to baseline, those who were adherent to the topical TTh had a 45-percent greater improvement, which reached statistical significance (239 vs 165 ng/dL; p<0.01).

After adjustments for covariates, adherence to TTh significantly predicted a mean increase of 63 mg/dL in testosterone concentrations relative to nonadherent participants (p<0.01).

In a separate multivariable analysis, geographical region, year of treatment initiation, prescribing physician, and baseline depression, hypertension, obesity and osteoporosis were all significant predictors of adherence.

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Most Read Articles
Roshini Claire Anthony, 5 days ago

A genotype-guided approach to warfarin dosing may result in fewer dose adjustments in Asian patients, according to a study from Singapore.

10 Aug 2018

Fungal microbiome, also called the mycobiome, appears to be highly variable in patients with well-characterized fungal diseases, a recent study has shown. Moreover, severe asthmatics have the highest fungal loads, along with those receiving steroid and antifungal therapy.

Tristan Manalac, 6 days ago
The risk of complicated appendicitis is lower in children with IgE-mediated allergy, according to a recent study.
21 Jul 2018
Although many patients with atopic dermatitis (AD) use antihistamines, no high-level evidence exists to prove that nonsedating antihistamines reduce itch in patients with AD or provide benefit in controlling AD symptoms, except perhaps sleep and AD comorbidities such as allergic rhinitis, according to a study.