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Roshini Claire Anthony, 3 days ago

The combined use of piperacillin and tazobactam does not appear to be a suitable alternative to meropenem for patients with bloodstream infections caused by ceftriaxone-resistant Escherichia coli (E. coli) or Klebsiella pneumoniae (K. pneumoniae), according to results of the MERINO* trial.

Tristan Manalac, 6 days ago
Taking oral antibiotics appears to increase the risk of nephrolithiasis, according to a recent study. Moreover, the risk seems to be compounded for individuals with recent antibiotic exposure and those who were exposed at a younger age.
Yesterday
Patients with inflammatory bowel disease are at increased risk of developing acute myocardial infarction (AMI) or heart failure, although the prevalence of traditional risk factors for such cardiovascular disorders appears to be low, as reported in a recent study.
2 days ago
Early renin-angiotensin-aldosterone system (RAAS) blockade with renin-angiotensin system inhibitors (RASI) leads to better short- and long-term renal outcomes in systemic lupus erythematosus (SLE) patients with antiphospholipid-associated nephropathy (aPLN), according to a study, adding that this renal protective effect is independent of RASI’s antihypertensive and antiproteinuric effects.

Higher adherence to topical testosterone improves clinical outcomes in men with hypogonadism

11 Feb 2018

In males with primary or secondary hypogonadism (HG), adherence to topical testosterone therapy (TTh) appears to improve total testosterone and decrease the risk of conditions associated with HG, a recent study has shown.

Researchers performed a retrospective cohort study of 3,184 adult males (mean age 49 years) with primary or secondary HG initiating topical TTh. The rate of complete adherence for 12 months was only 16.9 percent (n=538). Majority of the participants (91 percent) were prescribed topical gels.

High adherence was associated with better clinical outcomes. For instance, the composite endpoint of fatigue, osteoarthritis, insomnia, depression and erectile dysfunction was significantly lower in those adherent to the topical TTh (adjusted odds ratio [OR], 0.764; 95 percent CI, 0.617–0.947; p=0.014).

The secondary composite outcome of obesity, diabetes or metabolic syndrome was not significantly affected by adherence (adjusted OR, 0.952; 0.723–1.252; p=0.723). None of the individual composite components were also significantly correlated with adherence.

While both adherent and nonadherent males experienced increases in total testosterone levels relative to baseline, those who were adherent to the topical TTh had a 45-percent greater improvement, which reached statistical significance (239 vs 165 ng/dL; p<0.01).

After adjustments for covariates, adherence to TTh significantly predicted a mean increase of 63 mg/dL in testosterone concentrations relative to nonadherent participants (p<0.01).

In a separate multivariable analysis, geographical region, year of treatment initiation, prescribing physician, and baseline depression, hypertension, obesity and osteoporosis were all significant predictors of adherence.

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Most Read Articles
Roshini Claire Anthony, 3 days ago

The combined use of piperacillin and tazobactam does not appear to be a suitable alternative to meropenem for patients with bloodstream infections caused by ceftriaxone-resistant Escherichia coli (E. coli) or Klebsiella pneumoniae (K. pneumoniae), according to results of the MERINO* trial.

Tristan Manalac, 6 days ago
Taking oral antibiotics appears to increase the risk of nephrolithiasis, according to a recent study. Moreover, the risk seems to be compounded for individuals with recent antibiotic exposure and those who were exposed at a younger age.
Yesterday
Patients with inflammatory bowel disease are at increased risk of developing acute myocardial infarction (AMI) or heart failure, although the prevalence of traditional risk factors for such cardiovascular disorders appears to be low, as reported in a recent study.
2 days ago
Early renin-angiotensin-aldosterone system (RAAS) blockade with renin-angiotensin system inhibitors (RASI) leads to better short- and long-term renal outcomes in systemic lupus erythematosus (SLE) patients with antiphospholipid-associated nephropathy (aPLN), according to a study, adding that this renal protective effect is independent of RASI’s antihypertensive and antiproteinuric effects.