High waist circumference predicts mortality in peritoneal dialysis patients
In peritoneal dialysis (PD) patients, a high waist circumference (WC) and its corresponding increase over time are both significant predictors of mortality, a recent study has found.
Over a 48-month study period, 27 of the 109 patients (mean age 52±16 years; 57 percent male) on PD died. The most common cause of death was cardiovascular disease (n=12). This was followed by sepsis (n=11), infections (n=12), respiratory failure (n=1) and multiple organ failure (n=1). Participants with ascites, hernia or cancers, and those who were on corticosteroids were excluded.
Cox regression analysis showed that high baseline WC (hazard ratio [HR], 71; 95 percent CI, 1.2 to 43.2; p=0.03) and the 6-month increase in WC (HR, 13.6; 2.2 to 83.8; p=0.01) were both significantly correlated with mortality after adjusting for sex, age, diabetes mellitus, time on dialysis, albumin, BMI and C-reactive protein (CRP).
“The current finding is relevant as available data show that PD patients accumulate body fat over time, particularly in the abdominal area,” said researchers. [Perit Dial Int 1998;18:166-171; Perit Dial Int 2010; 31:67-73]
Along with WC, body weight and height of the participants were also measured; BMI was subsequently calculated. Male participants with >102 cm and female participants with >88 cm WC were designated as high risk participants.
Fasting blood samples were collected and analysed for measurements of serum glucose, albumin and high-sensitivity CRP.
Because high WC and its 6-month increase were both significant predictors of mortality in PD patients, researchers recommended the inclusion of WC monitoring and management in the routine care for patients on PD.