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High waist circumference predicts mortality in peritoneal dialysis patients

06 Sep 2017
Every 4 inches added to a man's waist line translates to a 13 percent risk for prostate cancer.

In peritoneal dialysis (PD) patients, a high waist circumference (WC) and its corresponding increase over time are both significant predictors of mortality, a recent study has found.

Over a 48-month study period, 27 of the 109 patients (mean age 52±16 years; 57 percent male) on PD died. The most common cause of death was cardiovascular disease (n=12). This was followed by sepsis (n=11), infections (n=12), respiratory failure (n=1) and multiple organ failure (n=1). Participants with ascites, hernia or cancers, and those who were on corticosteroids were excluded.

Cox regression analysis showed that high baseline WC (hazard ratio [HR], 71; 95 percent CI, 1.2 to 43.2; p=0.03) and the 6-month increase in WC (HR, 13.6; 2.2 to 83.8; p=0.01) were both significantly correlated with mortality after adjusting for sex, age, diabetes mellitus, time on dialysis, albumin, BMI and C-reactive protein (CRP).

 “The current finding is relevant as available data show that PD patients accumulate body fat over time, particularly in the abdominal area,” said researchers. [Perit Dial Int 1998;18:166-171; Perit Dial Int 2010; 31:67-73]

Along with WC, body weight and height of the participants were also measured; BMI was subsequently calculated. Male participants with >102 cm and female participants with >88 cm WC were designated as high risk participants.

Fasting blood samples were collected and analysed for measurements of serum glucose, albumin and high-sensitivity CRP.

Because high WC and its 6-month increase were both significant predictors of mortality in PD patients, researchers recommended the inclusion of WC monitoring and management in the routine care for patients on PD.

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Most Read Articles
Pearl Toh, 6 days ago
A study finds no evidence that using pharmaceutical aids alone for smoking cessation helps improve the chances of successful quitting despite promising results in previous randomized trials and routine prescription of such drugs to help quit smoking.
Elvira Manzano, 3 days ago
Cancer patients at risk for recurrent venous thromboembolism (VTE) are less likely to experience recurrence with rivaroxaban compared with dalteparin, the Select-D trial has shown, ushering in a new standard of care (SoC) for cancer-related VTE.
2 days ago
Weight loss medications that have received the Food and Drug Administration (FDA) approval appear to confer only modest positive benefits for cardiometabolic risk profile, according to a study.
3 days ago
The risk of stroke and subsequent mortality is significantly elevated in patients with chronic kidney disease (CKD) and end-stage renal disease (ESRD), a recent study has shown.