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21 Sep 2020
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High-voltage pulsed radiofrequency of dorsal root ganglion helps relieve pain

09 Jan 2020

Delivering high-voltage pulsed radiofrequency (PRF) of dorsal root ganglion via a multifunctional electrode yields significant pain relief and may prove valuable in the treatment of chronic lumbosacral radicular pain with neuropathic features, according to a recent study.

The study included 41 patients randomized to receive two cycles of 240 seconds high-voltage PRF followed by the injection of local anaesthetics, hyaluronidase and betamethasone (PRF-EA; n=21) or to undergo sham stimulation followed by adhesiolysis (EA; n=20). Treatment was delivered at the affected lumbosacral roots, with patients, treating physicians and assessors blinded to intervention.

At follow-up, the intervention produced a significant reduction in radiating pain compared with sham stimulation. The respective mean Numeric Rating Scale scores decreased by –3.43 vs –1.75 after 1 month (p=0.031) and by –3.34 vs –0.80 after 6 months (p=0.005).

Furthermore, significantly more patients in the PRF-EA vs EA-only group achieved a pain reduction of ≥50 percent in the first month of follow-up (57 percent vs 25 percent; odds ratio [OR], 4.00, 95 percent confidence interval [CI], 1.057–15.138; p=0.037).

At 6 months, only 10 percent of patients who underwent EA achieved significant pain relief as opposed to 48 percent of those who received radiofrequency and adhesiolysis (OR, 8.12, 95 percent CI, 1.505–44.491; p=0.008).

These findings, if confirmed, represent a significant step forward in the treatment of challenging neuropathic pain syndromes, according to the researchers. This underscores a need for randomized controlled trials testing the long-term effects of PRF in order to evaluate the contribution of the technique in pain management.

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Most Read Articles
21 Sep 2020
Chest pain appears to be the principal complaint of patients hospitalized with a first myocardial infarction (MI), particularly among those in the youngest age group, a study has found.
Jairia Dela Cruz, 16 Sep 2020
In patients with heart failure with reduced ejection fraction (HFrEF) receiving angiotensin-converting-enzyme (ACE) inhibitors, high dosing confers benefits for the risk of death or hospitalization that are similar to that obtained with lower dosing, according to a systematic review and meta-analysis.
Pearl Toh, 6 days ago
Early and sustained treatments with simplified regimen are the key to achieving good asthma control, said experts during a presentation at the ERS 2020 Congress.
2 days ago
Percutaneous coronary intervention (PCI), compared with coronary artery bypass grafting (CABG), in the revascularization of left main coronary artery (LMCA) disease may lead to death, myocardial infarction (MI), or stroke in patients with moderate or severe left ventricular (LV) dysfunction, reveals a study.