Most Read Articles
01 Dec 2019
Macrolide antibiotics are derived from the Streptomycesspecies. These contain either 14-membered (erythromycin [ERM],clarithromycin [CAM], roxithromycin [RXM]), 15-membered(azithromycin [AZM]) or 16-membered (spiramycin, josamycin,midecamycin) macrocyclic lactone rings. They inhibit proteinsynthesis by reversibly binding to the 23S ribosomal RNA (rRNA)in the 50s subunit of the bacterial ribosome. Traditionally,macrolides are used as first-line agents in respiratory, skin,soft tissue, and urogenital infections, and they are also activeagainst gram-positive cocci and atypical pathogens.
Roshini Claire Anthony, 6 days ago

The presence of pulmonary arterial hypertension (PAH) in individuals with systemic sclerosis is associated with an increased mortality risk, a study from Singapore showed.

01 Dec 2019
Pneumonia is a common infection– affecting around 3,200 people inSingapore in 2016 – making it the thirdmost common cause of hospitalisation inthe country. Its common complications,especially with delayed or inappropriatetreatment, include bacteraemia andseptic shock, lung abscesses, pleuraleffusions, empyema, pleurisy, respiratoryfailure and renal failure.
23 Dec 2019
At a Menarini-sponsored symposium held during the Asian Pacific Society Congress, renowned cardiologist Prof John Camm provided the latest evidence for chronic stable angina with or without concomitant diseases, with a special focus on the antianginal agent ranolazine and combination therapies. The event was chaired and moderated by Dr Dante Morales from the University of the Philippines College of Medicine.

High-voltage pulsed radiofrequency of dorsal root ganglion helps relieve pain

09 Jan 2020

Delivering high-voltage pulsed radiofrequency (PRF) of dorsal root ganglion via a multifunctional electrode yields significant pain relief and may prove valuable in the treatment of chronic lumbosacral radicular pain with neuropathic features, according to a recent study.

The study included 41 patients randomized to receive two cycles of 240 seconds high-voltage PRF followed by the injection of local anaesthetics, hyaluronidase and betamethasone (PRF-EA; n=21) or to undergo sham stimulation followed by adhesiolysis (EA; n=20). Treatment was delivered at the affected lumbosacral roots, with patients, treating physicians and assessors blinded to intervention.

At follow-up, the intervention produced a significant reduction in radiating pain compared with sham stimulation. The respective mean Numeric Rating Scale scores decreased by –3.43 vs –1.75 after 1 month (p=0.031) and by –3.34 vs –0.80 after 6 months (p=0.005).

Furthermore, significantly more patients in the PRF-EA vs EA-only group achieved a pain reduction of ≥50 percent in the first month of follow-up (57 percent vs 25 percent; odds ratio [OR], 4.00, 95 percent confidence interval [CI], 1.057–15.138; p=0.037).

At 6 months, only 10 percent of patients who underwent EA achieved significant pain relief as opposed to 48 percent of those who received radiofrequency and adhesiolysis (OR, 8.12, 95 percent CI, 1.505–44.491; p=0.008).

These findings, if confirmed, represent a significant step forward in the treatment of challenging neuropathic pain syndromes, according to the researchers. This underscores a need for randomized controlled trials testing the long-term effects of PRF in order to evaluate the contribution of the technique in pain management.

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Most Read Articles
01 Dec 2019
Macrolide antibiotics are derived from the Streptomycesspecies. These contain either 14-membered (erythromycin [ERM],clarithromycin [CAM], roxithromycin [RXM]), 15-membered(azithromycin [AZM]) or 16-membered (spiramycin, josamycin,midecamycin) macrocyclic lactone rings. They inhibit proteinsynthesis by reversibly binding to the 23S ribosomal RNA (rRNA)in the 50s subunit of the bacterial ribosome. Traditionally,macrolides are used as first-line agents in respiratory, skin,soft tissue, and urogenital infections, and they are also activeagainst gram-positive cocci and atypical pathogens.
Roshini Claire Anthony, 6 days ago

The presence of pulmonary arterial hypertension (PAH) in individuals with systemic sclerosis is associated with an increased mortality risk, a study from Singapore showed.

01 Dec 2019
Pneumonia is a common infection– affecting around 3,200 people inSingapore in 2016 – making it the thirdmost common cause of hospitalisation inthe country. Its common complications,especially with delayed or inappropriatetreatment, include bacteraemia andseptic shock, lung abscesses, pleuraleffusions, empyema, pleurisy, respiratoryfailure and renal failure.
23 Dec 2019
At a Menarini-sponsored symposium held during the Asian Pacific Society Congress, renowned cardiologist Prof John Camm provided the latest evidence for chronic stable angina with or without concomitant diseases, with a special focus on the antianginal agent ranolazine and combination therapies. The event was chaired and moderated by Dr Dante Morales from the University of the Philippines College of Medicine.