Most Read Articles
Dr. Joseph Delano Fule Robles, 14 Nov 2017

A recent study conducted by The University of Hong Kong (HKU) revealed that long-term use of proton pump inhibitors (PPIs) is associated with a significantly increased risk of gastric cancer even in patients who have had Helicobacter pylori eradicated. 

14 Nov 2017
The 5-year survival rates for human papillomavirus (HPV)-associated cancers vary greatly according to age and race, with Caucasians and younger patients tending to have better survival, according to a recent US study.
6 days ago
Both hatha yoga and a low-FODMAP (Fermentable, Oligo-, Di-, Monosaccharides and Polyol) diet can alleviate gastrointestinal symptoms, as well as improve a range of other psychological and physiological health parameters, in patients with irritable bowel syndrome (IBS), a study has shown.
6 days ago
Men with breast cancer have tumours that are typically of the human epidermal growth factor receptor 2-negative Luminal B subtype and positive for oestrogen receptor, progesterone receptor and androgen receptor, according to the results of the EORTC 10085/TBCRC/BIG/NABCG International Male Breast Cancer Program study.

High vitamin D levels may prevent death in patients with CKD

16 Jul 2017

Higher serum levels of 25-hydroxyvitamin D (25[OH]D) may likely reduce the risk of all-cause mortality in patients with chronic kidney disease (CKD), reports a study. However, evidence is inconclusive with regard to serum levels of >35 ng/mL.

To investigate the association between different levels of serum 25(OH)D and risk of all-cause mortality, researchers systematically searched Medline and Embase from inception to November 2016 for studies that reported risk estimates of all-cause mortality for three or more categories of serum 25(OH)D in patients with CKD. Also included were those that reported results as continuous.

A total of 1,281 studies were identified, of which 13 prospective cohort studies, two retrospective cohort studies and one nested case-control study were included. These involved 17,053 patients and 7,517 incident deaths.

The authors used a random-effects models to combine reported risk estimates. Summary risk estimates of all-cause mortality were 1.63 (95 percent CI, 1.32 to 1.94) for severe vitamin D deficiency (<10 ng/ml), 1.22 (1.09 to 1.35) for mild deficiency (10 to 20 ng/mL) and 1.12 (1.06 to 1.18) for insufficiency (20 to 30 ng/mL). These findings were more evident in dialysis-dependent patients.

A 10-ng/mL increase in serum 25(OH)D was associated with a 21-percent decrease in the risk of overall mortality (relative risk, 0.79; 0.70 to 0.87). There was also a lower risk of all-cause mortality at a serum 25(OH)D of 25 to 30 ng/mL. One of the sources of variation between studies was dialysis treatment.

Patients with CKD have a high prevalence of vitamin D deficiency, according to researchers.

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Most Read Articles
Dr. Joseph Delano Fule Robles, 14 Nov 2017

A recent study conducted by The University of Hong Kong (HKU) revealed that long-term use of proton pump inhibitors (PPIs) is associated with a significantly increased risk of gastric cancer even in patients who have had Helicobacter pylori eradicated. 

14 Nov 2017
The 5-year survival rates for human papillomavirus (HPV)-associated cancers vary greatly according to age and race, with Caucasians and younger patients tending to have better survival, according to a recent US study.
6 days ago
Both hatha yoga and a low-FODMAP (Fermentable, Oligo-, Di-, Monosaccharides and Polyol) diet can alleviate gastrointestinal symptoms, as well as improve a range of other psychological and physiological health parameters, in patients with irritable bowel syndrome (IBS), a study has shown.
6 days ago
Men with breast cancer have tumours that are typically of the human epidermal growth factor receptor 2-negative Luminal B subtype and positive for oestrogen receptor, progesterone receptor and androgen receptor, according to the results of the EORTC 10085/TBCRC/BIG/NABCG International Male Breast Cancer Program study.