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05 Dec 2017
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High vitamin D levels may prevent death in patients with CKD

16 Jul 2017

Higher serum levels of 25-hydroxyvitamin D (25[OH]D) may likely reduce the risk of all-cause mortality in patients with chronic kidney disease (CKD), reports a study. However, evidence is inconclusive with regard to serum levels of >35 ng/mL.

To investigate the association between different levels of serum 25(OH)D and risk of all-cause mortality, researchers systematically searched Medline and Embase from inception to November 2016 for studies that reported risk estimates of all-cause mortality for three or more categories of serum 25(OH)D in patients with CKD. Also included were those that reported results as continuous.

A total of 1,281 studies were identified, of which 13 prospective cohort studies, two retrospective cohort studies and one nested case-control study were included. These involved 17,053 patients and 7,517 incident deaths.

The authors used a random-effects models to combine reported risk estimates. Summary risk estimates of all-cause mortality were 1.63 (95 percent CI, 1.32 to 1.94) for severe vitamin D deficiency (<10 ng/ml), 1.22 (1.09 to 1.35) for mild deficiency (10 to 20 ng/mL) and 1.12 (1.06 to 1.18) for insufficiency (20 to 30 ng/mL). These findings were more evident in dialysis-dependent patients.

A 10-ng/mL increase in serum 25(OH)D was associated with a 21-percent decrease in the risk of overall mortality (relative risk, 0.79; 0.70 to 0.87). There was also a lower risk of all-cause mortality at a serum 25(OH)D of 25 to 30 ng/mL. One of the sources of variation between studies was dialysis treatment.

Patients with CKD have a high prevalence of vitamin D deficiency, according to researchers.

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Most Read Articles
05 Dec 2017
Survival in age-related macular degeneration (AMD) may be lower in patients with late disease, bilateral cataract surgery and poor visual acuity, according to data from the Age-Related Eye Disease Study 2. Moreover, oral supplementation with omega-3 fatty acids, lutein plus zeaxanthin, zinc or beta-carotene does not significantly affect mortality.
Jairia Dela Cruz, 05 Dec 2017
Discontinuation of aspirin may have detrimental consequences for long-term users, with a recent study reporting that cessation of use in the absence of major surgery or bleeding increases the risk of cardiovascular events.
4 days ago
Cognitive deficits in bipolar disorder are neurodevelopmental rather than neurodegenerative in nature, a recent study has reported. Furthermore, cognitive impairment in bipolar patients appears to be stable, in the majority at least.
3 days ago
Hydrochlorothiazide (HCTZ) appears to significantly increase the risks of nonmelanoma skin cancer (NMSC), particularly squamous cell carcinoma (SCC), a recent study has shown.