Most Read Articles
3 days ago
The appropriate cutoff value in predicting combined cardiovascular outcomes in patients with type 2 diabetes (T2D) is 125 mm Hg for home morning systolic blood pressure (MSBP), suggests a new study.
06 Apr 2018

Female patients with coronary artery disease (CAD) have greater regression of coronary atherosclerosis than male patients despite a lower plaque burden at baseline, data from the GLAGOV trial have shown.

26 Apr 2018
Transcatheter aortic valve replacement (TAVR) in severe symptomatic aortic stenosis (AS) patients is superior to conventional surgical aortic valve replacement (SAVR) in terms of reducing life-threatening bleeding, new-onset atrial fibrillation and acute kidney injury, a recent meta-analysis has found.
Pearl Toh, 2 days ago
Whether the 2017 ACC/AHA* blood pressure (BP) guidelines should be adopted in Asian countries was the topic of a much-anticipated discussion here at the Asian Pacific Society of Cardiology (APSC) Congress 2018 in Taiwan last week.

High uric acid concentrations tied to hypertension

06 Sep 2017

Higher concentrations of serum and urinary uric acid may predict higher 24-hour mean arterial pressure (MAP) and hypertension, a recent study suggests.

Researchers performed cross-sectional analysis in 2,555 individuals (mean age 60.0 years; 52 percent men; 27 percent had type 2 diabetes) from The Maastricht Study. They also conducted multivariable regression analyses to assess the association of serum uric acid concentration and 24-hour urinary uric acid excretion, as proxy for uric acid production, with ambulatory 24-hour blood pressure, 24-hour MAP and hypertension.

Serum uric acid concentration (per SD of 81 μmol/l) correlated with higher 24-hour MAP (β, 0.63 mm Hg; 95 percent CI, 0.27 to 1.00) and positively correlated with hypertension (odds ratio [OR], 1.43; 1.27 to 1.61) after adjustment for traditional hypertension risk factors. Urinary uric acid excretion (per SD of 140 mg/day/1.73 m2) was associated with higher 24-hour MAP (β, 0.79 mm Hg; 0.46 to 1.12) and with hypertension (OR, 1.13; 1.02 to 1.25).

Moreover, serum and 24-hour urinary uric acid excretion were not significantly correlated with 24-hour pulse pressure. No interaction with sex or age existed for the said associations.

“These results suggest that serum and 24-hour urinary uric acid concentrations, the latter as proxy for uric acid production are, independent of each other, associated with BP and hypertension,” according to researchers.

“Accumulation of reactive oxygen species by increased uric acid production has been suggested as a possible underlying mechanism for the association between uric acid and high blood pressure,” they added.

In The Maastricht Study, researchers did not find evidence supporting the hypothesis that generalized microvascular dysfunction was the underlying mechanism for the association between uric acid and cardiovascular and renal diseases. [J Hypertens 2015;33:1651-7]

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Most Read Articles
3 days ago
The appropriate cutoff value in predicting combined cardiovascular outcomes in patients with type 2 diabetes (T2D) is 125 mm Hg for home morning systolic blood pressure (MSBP), suggests a new study.
06 Apr 2018

Female patients with coronary artery disease (CAD) have greater regression of coronary atherosclerosis than male patients despite a lower plaque burden at baseline, data from the GLAGOV trial have shown.

26 Apr 2018
Transcatheter aortic valve replacement (TAVR) in severe symptomatic aortic stenosis (AS) patients is superior to conventional surgical aortic valve replacement (SAVR) in terms of reducing life-threatening bleeding, new-onset atrial fibrillation and acute kidney injury, a recent meta-analysis has found.
Pearl Toh, 2 days ago
Whether the 2017 ACC/AHA* blood pressure (BP) guidelines should be adopted in Asian countries was the topic of a much-anticipated discussion here at the Asian Pacific Society of Cardiology (APSC) Congress 2018 in Taiwan last week.