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01 Dec 2020
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Dr. Hsu Li Yang, Dr. Tan Thuan Tong, Dr. Andrea Kwa, 08 Jan 2021
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High sugar intake ups risk of cancer

24 Nov 2020

Avoiding sugar in the diet may help prevent cancer, particularly breast, suggests a recent study, contributing to the debate of the implementation of sugar taxation, marketing regulation, and other sugar-related policies.

“Excessive sugar intake is now recognized as a key risk factor for obesity, type 2 diabetes, and cardiovascular diseases,” the authors said. “Experimental data suggest that sugars could play a role in cancer aetiology through obesity but also through inflammatory and oxidative mechanisms and insulin resistance, even in the absence of weight gain.”

A total of 101,279 participants aged >18 years (median age, 40.8 years) from the French NutriNet-Santé prospective cohort study (2009–2019) were included in this research (median follow-up time, 5.9 years), which sought to examine the associations between total and added sugar intake and cancer risk (overall, breast, and prostate), while taking into account sugar types and sources.

Repeated and validated 24-h dietary records, designed to register participants’ usual consumption for >3,500 food and beverage items, were utilized to assess sugar intake. Cox proportional hazard models adjusted for known risk factors (ie, sociodemographic, anthropometric, lifestyle, medical history, and nutritional factors) were used to examine the associations between sugar intake and cancer risk.

Total sugar intake correlated with higher overall cancer risk (n=2,503 cases; hazard ratio [HR] for quartile 4 compared with quartile 1, 1.17, 95 percent confidence interval [CI], 1.00–1.37; p=0.02). Specifically, the risk for breast cancer was most increased (n=783; HR, 1.51, 95 percent CI, 1.14–2.00; p=0.0007).

The associations remained significant even after adjusting for weight gain during follow-up. Moreover, significant associations with cancer risk were seen for added sugars, free sugars, sucrose, sugars from milk-based desserts, dairy products, and sugary drinks (p≤0.01).

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Most Read Articles
01 Dec 2020
Tetanus toxoid 5 Lf, diphtheria toxoid 2 Lf, pertussis toxoid 2.5 mcg, filamentous haemagglutinin 5 mcg, fimbriae types 2 and 3 5 mcg, pertactin 3 mcg
Dr. Hsu Li Yang, Dr. Tan Thuan Tong, Dr. Andrea Kwa, 08 Jan 2021
Antimicrobial resistance has become increasingly dire as the rapid emergence of drug resistance, especially gram-negative pathogens, has outpaced the development of new antibiotics. At a recent virtual symposium, Dr Hsu Li Yang, Vice Dean (Global Health) and Programme Leader (Infectious Diseases), NUS Saw Swee Hock School of Public Health, presented epidemiological data on multidrug-resistant (MDR) gram-negative bacteria (GNB) in Asia, while Dr Tan Thuan Tong, Head and Senior Consultant, Department of Infectious Diseases, Singapore General Hospital (SGH), focused on the role of ceftazidime-avibactam in MDR GNB infections. Dr Andrea Kwa, Assistant Director of Research, Department of Pharmacy, SGH, joined the panel in an interactive fireside chat, to discuss challenges, practical considerations, and solutions in MDR gram-negative infections. This Pfizer-sponsored symposium was chaired by Dr Ng Shin Yi, Head and Senior Consultant of Surgical Intensive Care, SGH.
Pearl Toh, 26 Nov 2020
Inhaled corticosteroid (ICS) should be the mainstay of long-term asthma management — such is the key message of the latest Singapore ACE* Clinical Guidance (ACG) for asthma, released in October 2020.
4 days ago
Daily intake of cow’s milk formula in early life helps prevent the development of cow’s milk allergy later on without competing with breastfeeding, a recent study has found.