Most Read Articles
10 Jan 2018
Shared decision support with the use of standardized decision aids improves decision quality and reduces implantation of left ventricular assist device as destination therapy (DT-LVAD) in patients with advanced heart failure.
21 Dec 2017
Physicians’ practice patterns in managing hypertension, and their awareness of blood pressure variability, were reported in a recent study in Singapore. We discussed some of the clinical practice gaps identified by this study with author, A/Prof. Teo Boon Wee.
10 Jan 2018

A new batch of apolipoprotein B (apoB)-lowering drugs that capitalize on statins’ ability to lower lipids will further benefit patients at high cardiovascular (CV) risk who need to be treated more aggressively.

Pearl Toh, 15 Dec 2017
Blood pressure (BP) readings appeared to be similar regardless of whether BP measurements were attended or unattended by staff, nor were CV outcomes different between the two techniques, according to a post hoc survey on participants following the SPRINT* trial.

High sodium intake may impair cardiac structure, function

07 Aug 2017

Estimated sodium intake (ESI) greater than 3.7 g per day may result in adverse cardiac remodeling and worse systolic strain and diastolic e’ velocity, according to a study.

Researchers conducted speckle-tracking analysis on Hyper Genetic Epidemiology Network (HyperGEN) study echocardiograms with available urinary sodium data (n=2,996) to examine whether assessment of left ventricular longitudinal strain (LS), circumferential strain and e’ velocity could provide insight into thresholds for the detrimental effects of ESI on subclinical cardiovascular disease.

The associations among ESI and LS, circumferential strain and e’ velocity was evaluated using multivariable-adjusted linear mixed-effects models with linear splines (spline 1: ESI ≤3.7 g/day; spline 2: ESI >3.7 g/day based on visual inspection of fractional polynomial plots of the association between ESI and indices of strain and e′ velocity).

Researchers also sought to understand the indirect effects of systolic blood pressure (SBP) and serum aldosterone on the relationship between ESI and strain and e’ velocity by performing mediation analysis.

Participants (mean age 49 years; 57 percent female; 50 percent African American; 54 percent had hypertension) had a median ESI of 3.73 g/day. ESI >3.7 g/day correlated with larger left atrial and left ventricular dimensions (p<0.05).

Adjustments for several factors (such as speckle-tracking analyst, image quality, age, sex, study site, alcohol use, smoking status, daily blocks walked, diuretic use, estimated glomerular filtration rate, left ventricular mass, ejection fraction and wall motion score index) revealed that ESI >3.7 g/day was associated with both strain parameters and e’ velocity (p<0.05 for all comparisons), but ESI ≤3.7 g/day was not (p>0.05 for all comparisons).

Potassium excretion showed significant interactions for circumferential strain.

Based on mediation analysis, SBP explained 14 and 20 percent of indirect effects between ESI and LS and e’ velocity, respectively. On the other hand, serum aldosterone explained 19 percent of the indirect effects between ESI and LS.

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Most Read Articles
10 Jan 2018
Shared decision support with the use of standardized decision aids improves decision quality and reduces implantation of left ventricular assist device as destination therapy (DT-LVAD) in patients with advanced heart failure.
21 Dec 2017
Physicians’ practice patterns in managing hypertension, and their awareness of blood pressure variability, were reported in a recent study in Singapore. We discussed some of the clinical practice gaps identified by this study with author, A/Prof. Teo Boon Wee.
10 Jan 2018

A new batch of apolipoprotein B (apoB)-lowering drugs that capitalize on statins’ ability to lower lipids will further benefit patients at high cardiovascular (CV) risk who need to be treated more aggressively.

Pearl Toh, 15 Dec 2017
Blood pressure (BP) readings appeared to be similar regardless of whether BP measurements were attended or unattended by staff, nor were CV outcomes different between the two techniques, according to a post hoc survey on participants following the SPRINT* trial.