High serum uric acid ups risk of left ventricular dysfunction
High serum concentrations of uric acid (UA) correlate with reduced left ventricular ejection fraction (LVEF) among patients with cardiovascular diseases, a recent study has found.
A total of 3,077 patients (mean age 65.7±11.9 years; 82.4 percent male) with cardiac disorders participated in the study. Whole blood samples were collected from the participants and used for the quantification of plasma B-type natriuretic peptide (BNP), a known biomarker of heart failure, and UA.
Single regression analysis showed that plasma BNP, serum UA and LVEF were all significantly correlated with each other (p<0.001).
However, in multiple linear regression analysis, only the relationship between serum UA and LVEF remained significant (regression coefficient, –1.719; 95 percent CI –2.082 to –1.356; p<0.001), indicating that elevated UA was a clear risk factor for reduced LVEF. The link between UA and log BNP was attenuated (regression coefficient, 0.011; –0.003 to 0.026; p=0122).
Subsequent subgroup analyses, carried out using covariance structure analysis, further showed that in males, UA was significantly associated with LVEF (p<0.001) but not with log BNP (p=0.423), though there was a link between log BNP and LVEF (p<0.001). In females, UA was correlated with both LVEF and log BNP (p<0.001).
Several other paths of subgroup analyses further showed that while serum UA was consistently correlated with LVEF, “plasma BNP authentically responded to high serum UA, but only under the appropriate conditions, such as among lean aged females but never among obese, adolescent males,” said researchers.