Most Read Articles
Pearl Toh, 31 Dec 2019
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At a Menarini-sponsored symposium held during the Asian Pacific Society Congress, renowned cardiologist Prof John Camm provided the latest evidence for chronic stable angina with or without concomitant diseases, with a special focus on the antianginal agent ranolazine and combination therapies. The event was chaired and moderated by Dr Dante Morales from the University of the Philippines College of Medicine.
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Testosterone treatment may slightly improve sexual functioning and quality of life in men without underlying organic causes of hypogonadism, but it offers little to no benefit for other common symptoms of ageing, according to a study. In addition, long-term efficacy and safety of this therapy remain unknown.
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Prevention of glucocorticoid-induced osteoporosis (GIOP) and postmenopausal osteoporosis (PMOP) remains inadequate in patients with rheumatoid arthritis (RA), as shown in a study that evaluated the implementation of the 2003 and 2014 French guidelines on the prevention and treatment of GIOP and the 2012 update of the French guidelines for the treatment of PMOP.

High serum uric acid concentration ups death risk in old adults

2 days ago

Elevated concentrations of uric acid (UA) appear to predict mortality risk in older adults, a recent study has found.

The present observational study included 624 older adults (mean age, 77.2±14.6 years; 51 percent female) with UA measurements. Hyperuricaemia was defined as UA >7 mg/dL.

The average creatinine concentration was 1.4±1.4 mg/dL, falling above the normal level range of 0.52–1.04 mg/dL. The mean UA concentration in the study sample was 6.0±2.4 mg/dL. The normal range of values for males and females was 3.5–7.0 mg/dL and 2.6–6 mg/dL, respectively.

Over the 3.5-year follow-up period, a total of 381 participants died, yielding a mortality rate of 61.1 percent. This rate was significantly higher in participants who were hyperuricaemic than in those with normal levels (69.1 percent vs 58.4 percent; p=0.004).

Kaplan-Meier survival curves confirmed that mortality rates were significantly elevated in those with UA levels >7 mg/dL (p<0.0001). Moreover, median survival for participants hyperuricaemia was significantly shorter (606 vs 1,018 days; p<0.0001).

Cox regression analysis adjusted for age further showed that the only significant and independent predictor of overall mortality was an elevated serum UA concentration (odds ratio, 1.394, 95 percent confidence interval, 1.126–1.725; p=0.002).

“Further studies are needed to address possible effects of treatment of hyperuricaemia on survival. A double-blind, long-term study comparing prognosis of patients with hyperuricaemia with and without UA-lowering treatment would be the optimal method to answer the question of treating asymptomatic hyperuricaemic patients,” said researchers.

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Most Read Articles
Pearl Toh, 31 Dec 2019
Adding the neuraminidase inhibitor oseltamivir to usual care speeds up recovery from influenza-like illness by a day compared with usual care alone, with even greater benefits seen in older, sicker patients with comorbidities, according to the ALIC4E study.
23 Dec 2019
At a Menarini-sponsored symposium held during the Asian Pacific Society Congress, renowned cardiologist Prof John Camm provided the latest evidence for chronic stable angina with or without concomitant diseases, with a special focus on the antianginal agent ranolazine and combination therapies. The event was chaired and moderated by Dr Dante Morales from the University of the Philippines College of Medicine.
6 days ago
Testosterone treatment may slightly improve sexual functioning and quality of life in men without underlying organic causes of hypogonadism, but it offers little to no benefit for other common symptoms of ageing, according to a study. In addition, long-term efficacy and safety of this therapy remain unknown.
11 Jan 2020
Prevention of glucocorticoid-induced osteoporosis (GIOP) and postmenopausal osteoporosis (PMOP) remains inadequate in patients with rheumatoid arthritis (RA), as shown in a study that evaluated the implementation of the 2003 and 2014 French guidelines on the prevention and treatment of GIOP and the 2012 update of the French guidelines for the treatment of PMOP.