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High serum uric acid concentration ups death risk in old adults

16 Jan 2020

Elevated concentrations of uric acid (UA) appear to predict mortality risk in older adults, a recent study has found.

The present observational study included 624 older adults (mean age, 77.2±14.6 years; 51 percent female) with UA measurements. Hyperuricaemia was defined as UA >7 mg/dL.

The average creatinine concentration was 1.4±1.4 mg/dL, falling above the normal level range of 0.52–1.04 mg/dL. The mean UA concentration in the study sample was 6.0±2.4 mg/dL. The normal range of values for males and females was 3.5–7.0 mg/dL and 2.6–6 mg/dL, respectively.

Over the 3.5-year follow-up period, a total of 381 participants died, yielding a mortality rate of 61.1 percent. This rate was significantly higher in participants who were hyperuricaemic than in those with normal levels (69.1 percent vs 58.4 percent; p=0.004).

Kaplan-Meier survival curves confirmed that mortality rates were significantly elevated in those with UA levels >7 mg/dL (p<0.0001). Moreover, median survival for participants hyperuricaemia was significantly shorter (606 vs 1,018 days; p<0.0001).

Cox regression analysis adjusted for age further showed that the only significant and independent predictor of overall mortality was an elevated serum UA concentration (odds ratio, 1.394, 95 percent confidence interval, 1.126–1.725; p=0.002).

“Further studies are needed to address possible effects of treatment of hyperuricaemia on survival. A double-blind, long-term study comparing prognosis of patients with hyperuricaemia with and without UA-lowering treatment would be the optimal method to answer the question of treating asymptomatic hyperuricaemic patients,” said researchers.

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Most Read Articles
2 days ago
A recent study reports a mean growth rate of proximal aorta of about 0.1 mm/year in hypertensive patients with known aortic dilatation. In addition, those with increased rather than normal aortic z score have slower dilatation over time.
Tristan Manalac, Yesterday
The coronavirus disease 2019 (COVID-19) appears to be more dangerous among cancer patients, who tend suffer more severe complications and faster disease progression, according to a new study.
6 days ago
Knee osteoarthritis (OA), whether symptomatic or radiographic, contributes to an increased risk of all-cause mortality, with the risk increase from symptomatic knee OA partially attributed to its effect on disability and quality of life (QoL).
Yesterday
Cuff-based excess pressure (XSP) is modestly associated with carotid intima–media thickness independent of conventional risk factors, reveals a recent study.