Most Read Articles
06 Jun 2019
Having at least four pregnancies through childbearing age appears to increase the risk of diabetes in postmenopausal women without a history of gestational diabetes, a study has found.
Stephen Padilla, 07 Oct 2019
Almost half of Asian patients with dyslipidaemia and hypertension, as well as half of those on pharmacotherapy, have achieved their blood pressure (BP) treatment goals, a Singapore study has shown. Moreover, BP goal attainment is significantly associated with type 2 diabetes mellitus (T2DM) and low-density lipoprotein (LDL-C) control.
Roshini Claire Anthony, 30 Jul 2019

Individuals who adhere to a plant-based diet, particularly one consisting of healthy plant-based foods, may reduce their risk of developing type 2 diabetes (T2D), according to a recent meta-analysis.

Roshini Claire Anthony, 08 May 2019

Engaging in vigorous physical activity for 75 minutes or more per week could reduce glucose levels in women trying to conceive, a recent study from Singapore showed. However, this impact was not demonstrated in women who engaged in moderate physical activity for 150 minutes or more per week.

High serum phosphate may protect against hyperuricaemia in hypertensive patients

22 May 2019

There appears to be an inverse association between serum phosphate levels and the risk of developing hyperuricaemia among adult patients with hypertension, a study has found.

Researchers performed a posthoc analysis of the Uric Acid substudy of the China Stroke Primary Prevention Trial, including 10,612 participants with normal uric acid levels (<357 μmol/L [6 mg/dL]) at baseline.

In the cohort, the mean serum phosphate level was 1.3 mmol/L. Prevalence rates of mild (<0.8 mmol/L), moderate (<0.6 mmol/L) and severe (<0.4 mmol/L) hypophosphatemia were 1.0 percent, 0.4 percent and 0.4 percent, respectively. None of the participants with hypophosphatemia had arrhythmia or cardiomyopathy.

The primary outcome of new-onset hyperuricaemia, defined as a uric acid concentration of ≥417 μmol/L (7 mg/dL) in men or ≥357 μmol/L (6 mg/dL) in women, occurred in 1,663 participants (15.7 percent) over a median follow-up of 4.4 years.

Serum phosphate had a significant inverse association with the risk of new-onset hyperuricaemia (odds ratio [OR] per SD increment, 0.71; 95 percent CI, 0.66–0.76). When serum phosphate was assessed as quartiles, the risk was lowest in participants in quartile 4 (≥1.4 mmol/L; OR, 0.48; 0.40–0.57) relative to those in quartile 1 (<1.2 mmol/L). Results were similar in males and females.

The present data suggest that serum phosphate measurements, along with other known risk factors, may help pinpoint which hypertensive patients are at high risk of new-onset hyperuricaemia, researchers said. Targeting this high-risk population and implementing early management of multiple risk factors should reduce the risk of future hyperuricaemia and related diseases.

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Most Read Articles
06 Jun 2019
Having at least four pregnancies through childbearing age appears to increase the risk of diabetes in postmenopausal women without a history of gestational diabetes, a study has found.
Stephen Padilla, 07 Oct 2019
Almost half of Asian patients with dyslipidaemia and hypertension, as well as half of those on pharmacotherapy, have achieved their blood pressure (BP) treatment goals, a Singapore study has shown. Moreover, BP goal attainment is significantly associated with type 2 diabetes mellitus (T2DM) and low-density lipoprotein (LDL-C) control.
Roshini Claire Anthony, 30 Jul 2019

Individuals who adhere to a plant-based diet, particularly one consisting of healthy plant-based foods, may reduce their risk of developing type 2 diabetes (T2D), according to a recent meta-analysis.

Roshini Claire Anthony, 08 May 2019

Engaging in vigorous physical activity for 75 minutes or more per week could reduce glucose levels in women trying to conceive, a recent study from Singapore showed. However, this impact was not demonstrated in women who engaged in moderate physical activity for 150 minutes or more per week.