Most Read Articles
Joyce Lam Ching Mei, 28 Mar 2019
April 17 marks World Haemophilia Day, and this year’s theme is  “Reaching Out – The First Step to Care”. Adjunct Assoc Prof Joyce Lam Ching Mei, head of the Haematology Laboratory and Blood Bank and senior consultant from the Paediatric Haematology/Oncology Service at KK Women’s and Children’s Hospital, Singapore, speaks to Elaine Soliven on the importance of recognizing and managing bleeding disorders in primary care.
Tristan Manalac, 05 Nov 2019
Vaping nontraditional e-cigarette flavours, such as fruit and candy, supports the habit and may promote more frequent use, according to a new study.
Stephen Padilla, 31 Oct 2019
Intraoperative epidural analgesia, perioperative opioid and total dose of volatile agent appear to show some “clinically meaningful associations” with relapse-free survival (RFS) in children with solid organ tumour, particularly in paediatric sarcoma patients, according to a Singapore study. However, no statistically significant association exists between epidural use and an improved RFS.

High serum bilirubin lowers obesity risk in kids

20 Oct 2019

Serum bilirubin levels are inversely correlated with the risk of obesity in children, without increasing the likelihood of reduced IQ, a recent study has found.

The study included 28,489 infants, in whom serum bilirubin concentrations were measured using direct spectrophotometry or the diazo method. Measurements were collected as close to 48 hours as possible. Study outcomes were obesity and low IQ (<70) at 7 years of age.

A total of 2,406 participants were determined to have obesity, resulting an overall incidence rate of 8.45 percent.

Compared with infants who had total serum bilirubin (TSB) levels <3 mg/dL, the risk of obesity at age 7 years was lower in those with concentrations 3–6 mg/dL (adjusted odds ratio [OR], 0.91, 95 percent CI, 0.81–1.02), 6–9 mg/dL (adjusted OR, 0.88, 0.78–0.99) and 9–13 mg/dL (adjusted OR, 0.83, 0.71–0.98). This was untrue for those with TSB ≥13 mg/dL (adjusted OR, 1.04, 0.85–1.27).

Stratified analysis found that the concentrations of unconjugated bilirubin (UCB) shared a similar relationship with obesity risk. Relative to those with UCB <3 mg/dL, the risk of obesity at age 7 years was reduced in those with 3–6 mg/dL (adjusted OR, 0.93, 0.80–1.09), 6–9 mg/dL (adjusted OR, 0.86, 0.75–1.00) and 9–12 mg/dL (adjusted OR, 0.85, 0.73–0.99) UCB.

In contrast, levels of conjugated serum bilirubin showed a direct correlation with the likelihood of obesity, such that rising concentrations corresponded with increasing risks.

Moreover, higher TSB levels tended to increase the risk of low IQ at age 7 years, though none of the correlations achieved statistical significance. “Our findings may shed some light on investigations and interventions regarding the role of bilirubin in the prevention and treatment of obesity or obesity-related diseases,” said researchers.

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Most Read Articles
Joyce Lam Ching Mei, 28 Mar 2019
April 17 marks World Haemophilia Day, and this year’s theme is  “Reaching Out – The First Step to Care”. Adjunct Assoc Prof Joyce Lam Ching Mei, head of the Haematology Laboratory and Blood Bank and senior consultant from the Paediatric Haematology/Oncology Service at KK Women’s and Children’s Hospital, Singapore, speaks to Elaine Soliven on the importance of recognizing and managing bleeding disorders in primary care.
Tristan Manalac, 05 Nov 2019
Vaping nontraditional e-cigarette flavours, such as fruit and candy, supports the habit and may promote more frequent use, according to a new study.
Stephen Padilla, 31 Oct 2019
Intraoperative epidural analgesia, perioperative opioid and total dose of volatile agent appear to show some “clinically meaningful associations” with relapse-free survival (RFS) in children with solid organ tumour, particularly in paediatric sarcoma patients, according to a Singapore study. However, no statistically significant association exists between epidural use and an improved RFS.