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High-sensitivity cardiac troponin T a potential marker of cognitive impairment in stroke

12 May 2020

Higher levels of high-sensitivity cardiac troponin T (hs-cTnT) in ischaemic stroke patients without dementia translate to a higher prevalence of cognitive impairment at baseline and at the 3-year follow-up, according to data from PROSCIS-B* study.

PROSCIS-B involved 555 patients (mean age, 67 years; 62 percent male; median National Institutes of Health Stroke Scale, 2). Researchers assessed cognitive function using Mini-Mental State Examination (MMSE; scale, 0–30; cutoff for cognitive impairment: ≤26; n=544) at baseline, as well as with Telephone Interview for Cognitive Status–modified (TICS-m; scale, 0–50; cutoff for cognitive impairment: ≤31) after 1–3 years of follow-up.

Of the 456 patients with detectable baseline hs-cTnT, 219 (39.5 percent) exhibited increased levels (≥14 ng/L). This group of patients were older, had worse renal function and more comorbidities. Patients in the highest vs lowest hs-cTnT quartile had lower MMSE scores (median, 27 vs 29) and a higher prevalence of cognitive impairment based on MMSE (adjusted risk ratio [RR], 1.76, 95 percent confidence interval [CI], 1.07–2.90).

TICS-m scores during the follow-up were consistently lower in patients in the highest vs lowest quartile of hs-cTnT. At 1 year, the adjusted RR for cognitive impairment based on TICS-m was 1.38 (95 percent CI, 1.01–1.87).

There were no considerable changes observed in poststroke cognitive function over time in any group, indicating that cognitive function after follow-up depended mainly on baseline cognitive performance, the researchers explained.

Additional investigation is warranted to explore whether cardiac biomarkers can be used to predict poststroke cognitive impairment, they added.

*Prospective Cohort With Incident Stroke Berlin

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Most Read Articles
13 Sep 2020
Regardless of birth weight, being obese at preschool age is associated with a greater risk of elevated blood pressure during early childhood, a recent China study has found. A longer duration of breastfeeding appears to help mitigate such a risk.
Jairia Dela Cruz, 4 days ago
In patients with heart failure with reduced ejection fraction (HFrEF) receiving angiotensin-converting-enzyme (ACE) inhibitors, high dosing confers benefits for the risk of death or hospitalization that are similar to that obtained with lower dosing, according to a systematic review and meta-analysis.
06 Sep 2020
Type 2 diabetes mellitus patients taking proton pump inhibitors (PPIs) are at a higher risk of sustaining hip fractures, a recent study has found.
6 days ago
Osteoarthritis (OA) is the most common condition affecting the joints. Dr Lee Eu Jin, an Orthopaedic Surgeon from Liberty Orthopaedic Clinic at Mount Elizabeth Medical Centre, Singapore, shares his insights with Pearl Toh on how to manage OA in the primary care setting.