Most Read Articles
Roshini Claire Anthony, 29 May 2020

For coffee drinkers, drinking filtered coffee may be tied to a lower mortality risk, including cardiovascular disease (CVD)-related mortality, a study from Norway suggested.

5 days ago
Use of corticosteroid is not associated with improved outcomes in idiopathic pulmonary fibrosis (IPF) patients admitted to the hospital with acute exacerbation (AE), reveals a recent study. In addition, corticosteroids may even contribute to reduced overall survival following exacerbation.
Dr. Wong Soon Tee, 28 May 2020
Acne is a common skin problem seen in primary care. Dr Wong Soon Tee of Assurance Skin Clinic at Mt Elizabeth Novena Hospital, Singapore shares his insights with Pearl Toh on how to manage acne in the primary care setting.
27 May 2020
The perception that proton pump inhibitors (PPIs) cause multiple serious adverse effects (AEs) is supported by many internists, who then recommend treatment cessation even in patients at high risk for upper gastrointestinal bleeding (UGIB), reveals a study.

High-sensitivity cardiac troponin T a potential marker of cognitive impairment in stroke

12 May 2020

Higher levels of high-sensitivity cardiac troponin T (hs-cTnT) in ischaemic stroke patients without dementia translate to a higher prevalence of cognitive impairment at baseline and at the 3-year follow-up, according to data from PROSCIS-B* study.

PROSCIS-B involved 555 patients (mean age, 67 years; 62 percent male; median National Institutes of Health Stroke Scale, 2). Researchers assessed cognitive function using Mini-Mental State Examination (MMSE; scale, 0–30; cutoff for cognitive impairment: ≤26; n=544) at baseline, as well as with Telephone Interview for Cognitive Status–modified (TICS-m; scale, 0–50; cutoff for cognitive impairment: ≤31) after 1–3 years of follow-up.

Of the 456 patients with detectable baseline hs-cTnT, 219 (39.5 percent) exhibited increased levels (≥14 ng/L). This group of patients were older, had worse renal function and more comorbidities. Patients in the highest vs lowest hs-cTnT quartile had lower MMSE scores (median, 27 vs 29) and a higher prevalence of cognitive impairment based on MMSE (adjusted risk ratio [RR], 1.76, 95 percent confidence interval [CI], 1.07–2.90).

TICS-m scores during the follow-up were consistently lower in patients in the highest vs lowest quartile of hs-cTnT. At 1 year, the adjusted RR for cognitive impairment based on TICS-m was 1.38 (95 percent CI, 1.01–1.87).

There were no considerable changes observed in poststroke cognitive function over time in any group, indicating that cognitive function after follow-up depended mainly on baseline cognitive performance, the researchers explained.

Additional investigation is warranted to explore whether cardiac biomarkers can be used to predict poststroke cognitive impairment, they added.

*Prospective Cohort With Incident Stroke Berlin

Digital Edition
Asia's trusted medical magazine for healthcare professionals. Get your MIMS Doctor - Malaysia digital copy today!
Sign In To Download
Editor's Recommendations
Most Read Articles
Roshini Claire Anthony, 29 May 2020

For coffee drinkers, drinking filtered coffee may be tied to a lower mortality risk, including cardiovascular disease (CVD)-related mortality, a study from Norway suggested.

5 days ago
Use of corticosteroid is not associated with improved outcomes in idiopathic pulmonary fibrosis (IPF) patients admitted to the hospital with acute exacerbation (AE), reveals a recent study. In addition, corticosteroids may even contribute to reduced overall survival following exacerbation.
Dr. Wong Soon Tee, 28 May 2020
Acne is a common skin problem seen in primary care. Dr Wong Soon Tee of Assurance Skin Clinic at Mt Elizabeth Novena Hospital, Singapore shares his insights with Pearl Toh on how to manage acne in the primary care setting.
27 May 2020
The perception that proton pump inhibitors (PPIs) cause multiple serious adverse effects (AEs) is supported by many internists, who then recommend treatment cessation even in patients at high risk for upper gastrointestinal bleeding (UGIB), reveals a study.