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Dr. Joseph Delano Fule Robles, 11 Apr 2018

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High-sensitivity C-reactive protein as biomarker for cognitive decline

08 Jun 2018

High-sensitivity C-reactive protein (hs-CRP) concentration is significantly associated with long-term cognitive decline, according to a study. This suggests the possibility of CRP being a marker of cognitive decline and serving as the basis for early intervention to prevent further deterioration.

The study involved 5,257 individuals (mean age 65.4 years; 54.9 percent women) who were included in the waves 2–7 of the English Longitudinal Study of Ageing. Cognitive function was assessed at baseline (wave 2) and biennially (waves 3–7).

Median hs-CRP level at baseline was 2.0 mg/L (interquartile range, 0.9–4.1 mg/L). The mean number of cognitive assessment was 4.9, and the follow-up duration was 8.1 years.

In multivariable linear mixed models, a one-unit increment in natural log-transformed hs-CRP was associated with faster decline in the following: global cognitive scores (−0.048 points/year; 95 percent CI, −0.072 to −0.023), memory scores (−0.022 points/year; −0.031 to −0.013) and executive function scores (−0.025 points/year; −0.043 to −0.006).

When analysis was stratified according to quartiles of hs-CRP, global cognitive decline occurred at a rate of −0.145 points/year (−0.221 to −0.069) in the highest quartile, −0.090 points/year (−0.166 to −0.015) in the third quartile and −0.043 points/year (−0.116 to 0.029) in the second quartile than in the lowest quartile (p<0.001 for trend). Memory and executive function likewise declined faster with increasing quartiles of hs-CRP.

The present data show that elevated hs-CRP level could be a useful biomarker to identify individuals who are at greater risk of developing cognitive impairment and dementia, researchers said.

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Most Read Articles
Dr. Joseph Delano Fule Robles, 11 Apr 2018

A study recently showed that conversion disorder, also known as functional neurological disorder, is associated with stressful life events and maltreatment.

6 days ago
Medications used to treat alcohol and opioid use disorders appear to be also effective in reducing suicidality and crime during treatment, according to a recent study.