Most Read Articles
Tristan Manalac, 20 Dec 2018
Motor activity appears to play a central role in mood regulation, according to a recent study, which also reports that subjective energy is important in motor activity.
Dr. Joseph Delano Fule Robles, 30 Jan 2019

Five subtypes of insomnia disorder were identified by investigators from The Netherlands, addressing an unmet need to reduce the heterogeneity of insomnia disorder.

07 Sep 2018
Individuals with attention deficiency hyperactivity disorder (ADHD) or anxiety are at greater risk of developing bipolar disorder, according to a study. Moreover, the risk further increases in those who have received diagnoses of both ADHD and anxiety.
21 Nov 2018
Adults with bipolar disorder who had been maltreated as a child are more likely to have a medical illness than adults with unipolar depression who have had the same experience, according to a study.

High-sensitivity C-reactive protein as biomarker for cognitive decline

08 Jun 2018

High-sensitivity C-reactive protein (hs-CRP) concentration is significantly associated with long-term cognitive decline, according to a study. This suggests the possibility of CRP being a marker of cognitive decline and serving as the basis for early intervention to prevent further deterioration.

The study involved 5,257 individuals (mean age 65.4 years; 54.9 percent women) who were included in the waves 2–7 of the English Longitudinal Study of Ageing. Cognitive function was assessed at baseline (wave 2) and biennially (waves 3–7).

Median hs-CRP level at baseline was 2.0 mg/L (interquartile range, 0.9–4.1 mg/L). The mean number of cognitive assessment was 4.9, and the follow-up duration was 8.1 years.

In multivariable linear mixed models, a one-unit increment in natural log-transformed hs-CRP was associated with faster decline in the following: global cognitive scores (−0.048 points/year; 95 percent CI, −0.072 to −0.023), memory scores (−0.022 points/year; −0.031 to −0.013) and executive function scores (−0.025 points/year; −0.043 to −0.006).

When analysis was stratified according to quartiles of hs-CRP, global cognitive decline occurred at a rate of −0.145 points/year (−0.221 to −0.069) in the highest quartile, −0.090 points/year (−0.166 to −0.015) in the third quartile and −0.043 points/year (−0.116 to 0.029) in the second quartile than in the lowest quartile (p<0.001 for trend). Memory and executive function likewise declined faster with increasing quartiles of hs-CRP.

The present data show that elevated hs-CRP level could be a useful biomarker to identify individuals who are at greater risk of developing cognitive impairment and dementia, researchers said.

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Most Read Articles
Tristan Manalac, 20 Dec 2018
Motor activity appears to play a central role in mood regulation, according to a recent study, which also reports that subjective energy is important in motor activity.
Dr. Joseph Delano Fule Robles, 30 Jan 2019

Five subtypes of insomnia disorder were identified by investigators from The Netherlands, addressing an unmet need to reduce the heterogeneity of insomnia disorder.

07 Sep 2018
Individuals with attention deficiency hyperactivity disorder (ADHD) or anxiety are at greater risk of developing bipolar disorder, according to a study. Moreover, the risk further increases in those who have received diagnoses of both ADHD and anxiety.
21 Nov 2018
Adults with bipolar disorder who had been maltreated as a child are more likely to have a medical illness than adults with unipolar depression who have had the same experience, according to a study.