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High-molecular-weight adiponectin inversely linked to proinsulin

04 Jul 2020

High-molecular-weight adiponectin (HMWA) is inversely correlated with proinsulin in the general population, a new Japan study has found.

Researchers conducted a cross-sectional analysis of 488 participants (aged 35–79 years; 53.9 percent female) who were not on oral hypoglycaemic or insulin medication. Venous blood samples were collected for the laboratory measurement of proinsulin and HMWA.

The median serum HMWA was 3.6 µg/mL, while the median proinsulin level was 9.0 pmol/L. At baseline, participants had a median glycated haemoglobin level of 5.4 percent, and the homeostatic model assessment of insulin resistance (HOMA-IR) was at 1.0.

Univariate linear regression analysis revealed a statistically significant and inverse correlation between HMWA and proinsulin in the total study sample. This remained true even after adjusting for age and sex (β, –0.37, 95 percent confidence interval [CI], –0.46 to –0.28; p<0.01).

This interaction remained robust in subsequent stratified analyses. For instance, serum HMWA remained significantly and inversely associated with proinsulin in participants below (β, –0.24, 95 percent CI, –0.35 to –0.13; p<0.01) and at or above (β, –0.33, 95 percent CI, –0.47 to –0.19; p<0.01) the median body mass index value.

Disaggregation according to the median values of insulin and HOMA-IR yielded similarly significant correlations. Notably, serum HMWA retained its relationship with proinsulin even in participants with (β, –0.36, 95 percent CI, –0.68 to –0.04; p=0.03) and without (β, –0.32, 95 percent CI, –0.41 to –0.24; p<0.01) diabetes.

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Most Read Articles
Elaine Soliven, 5 days ago

Switching from efavirenz/emtricitabine/tenofovir disoproxil fumarate (EFV/FTC/TDF) to the new bictegravir/ emtricitabine/tenofovir alafenamide (BIC/FTC/TAF) regimen maintained high rates of virological suppression in adults who are living with HIV*, according to a study presented at AIDS 2020.

3 days ago
Among individuals with abdominal obesity, drinking beverages with artificial sweeteners (ASBs) or no sugar (USBs) instead of sugar-sweetened beverages (SSBs) helps lose body weight, a study has found. However, USBs have a more favourable effect on sweet taste preference compared with ASBs.
Stephen Padilla, 5 days ago
Pre-exposure prophylaxis (PrEP) containing either long-acting injectable cabotegravir (CAB) or tenofovir/emtricitabine (TDF/FTC) is safe and effective for transgender women (TGW) and cisgender men who have sex with men (MSM), but CAB results in a much lower HIV incidence compared to TDF/FTC, results of the HIV Prevention Trials Network (HPTN) 083 have shown.
Jairia Dela Cruz, 4 days ago
Monthly prophylaxis with the fixed-dose combination of naphthoquine-azithromycin (NQAZ) is well tolerated and confers significant protection against infection with Plasmodium parasites among individuals residing in malaria-endemic areas in Southeast Asia, as shown in the results of a phase III trial.