Most Read Articles
2 days ago
Dairy consumption during adolescence or early adulthood does not appear to be associated with the overall risk of breast cancer, although results vary by hormone receptor status of tumours, a study has shown. Specifically, dairy intake is linked to higher ER–/PR– and lower ER+/PR+ cancer risk.
Roshini Claire Anthony, 5 days ago

The combined use of piperacillin and tazobactam does not appear to be a suitable alternative to meropenem for patients with bloodstream infections caused by ceftriaxone-resistant Escherichia coli (E. coli) or Klebsiella pneumoniae (K. pneumoniae), according to results of the MERINO* trial.

3 days ago
Patients with inflammatory bowel disease are at increased risk of developing acute myocardial infarction (AMI) or heart failure, although the prevalence of traditional risk factors for such cardiovascular disorders appears to be low, as reported in a recent study.
4 days ago
Early renin-angiotensin-aldosterone system (RAAS) blockade with renin-angiotensin system inhibitors (RASI) leads to better short- and long-term renal outcomes in systemic lupus erythematosus (SLE) patients with antiphospholipid-associated nephropathy (aPLN), according to a study, adding that this renal protective effect is independent of RASI’s antihypertensive and antiproteinuric effects.

High low-carbohydrate diet scores up risk of diabetes mellitus

21 Jul 2017
There are many much beloved sources of carbohydrates we can taste, according to new findings

Compared with the lowest scores, the highest low-carbohydrate diet (LCD) scores are associated with a 17 percent higher risk of diabetes mellitus (DM), according to a new meta-analysis.

A meta-analysis of four eligible cohort studies (n=8,018) reporting on the effects of LCD on the risk of DM showed that the highest LCD scores had significantly higher risks of DM than the lowest scores (overall relative risk [RR], 1.17; 95 percent CI, 0.90 to 1.51; p=0.001).

Subgroup analysis was performed because of the high degree of heterogeneity (p<0.001). Adjustment for energy also yielded a correlation between DM risk and high LCD scores (RR, 1.32; 1.17 to 1.49) and removed heterogeneity (p=0.96).

Studies with follow-up periods of ≤12 years showed a significant association between risk of DM and high LCD scores (RR, 1.35; 1.05 to 1.75). Moreover, studies with quality scores <7 yielded significant correlations between DM risk and LCD scores (RR, 1.31; 1.15 to 1.49) while those with ≥7 quality scores did not (RR, 1.09; 0.73 to 1.63).

Studies for the meta-analysis were retrieved from PubMed, Google Scholar, ISI Web of Science, Embase and Scopus. The search yielded 14 original studies which were further reduced to four after excluding noncohort studies and those with irrelevant outcome reports.

One study focused on males, two on females and the remaining one on both sexes. Participants were aged anywhere from 13.8 to 75 years; follow-up duration ranged from 3.6 to 20 years.

The quality scores of the studies, measured by the Newcastle-Ottawa Scale, ranged from six to eight, indicating good- to high methodological quality in general.

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Most Read Articles
2 days ago
Dairy consumption during adolescence or early adulthood does not appear to be associated with the overall risk of breast cancer, although results vary by hormone receptor status of tumours, a study has shown. Specifically, dairy intake is linked to higher ER–/PR– and lower ER+/PR+ cancer risk.
Roshini Claire Anthony, 5 days ago

The combined use of piperacillin and tazobactam does not appear to be a suitable alternative to meropenem for patients with bloodstream infections caused by ceftriaxone-resistant Escherichia coli (E. coli) or Klebsiella pneumoniae (K. pneumoniae), according to results of the MERINO* trial.

3 days ago
Patients with inflammatory bowel disease are at increased risk of developing acute myocardial infarction (AMI) or heart failure, although the prevalence of traditional risk factors for such cardiovascular disorders appears to be low, as reported in a recent study.
4 days ago
Early renin-angiotensin-aldosterone system (RAAS) blockade with renin-angiotensin system inhibitors (RASI) leads to better short- and long-term renal outcomes in systemic lupus erythematosus (SLE) patients with antiphospholipid-associated nephropathy (aPLN), according to a study, adding that this renal protective effect is independent of RASI’s antihypertensive and antiproteinuric effects.