Most Read Articles
01 Dec 2020
Tetanus toxoid 5 Lf, diphtheria toxoid 2 Lf, pertussis toxoid 2.5 mcg, filamentous haemagglutinin 5 mcg, fimbriae types 2 and 3 5 mcg, pertactin 3 mcg
Dr. Hsu Li Yang, Dr. Tan Thuan Tong, Dr. Andrea Kwa, 08 Jan 2021
Antimicrobial resistance has become increasingly dire as the rapid emergence of drug resistance, especially gram-negative pathogens, has outpaced the development of new antibiotics. At a recent virtual symposium, Dr Hsu Li Yang, Vice Dean (Global Health) and Programme Leader (Infectious Diseases), NUS Saw Swee Hock School of Public Health, presented epidemiological data on multidrug-resistant (MDR) gram-negative bacteria (GNB) in Asia, while Dr Tan Thuan Tong, Head and Senior Consultant, Department of Infectious Diseases, Singapore General Hospital (SGH), focused on the role of ceftazidime-avibactam in MDR GNB infections. Dr Andrea Kwa, Assistant Director of Research, Department of Pharmacy, SGH, joined the panel in an interactive fireside chat, to discuss challenges, practical considerations, and solutions in MDR gram-negative infections. This Pfizer-sponsored symposium was chaired by Dr Ng Shin Yi, Head and Senior Consultant of Surgical Intensive Care, SGH.
Jairia Dela Cruz, 5 days ago
Spending too much time sitting cannot be good for the body, and rising to one's feet breaks up such a behaviour and yields small, but meaningful, reductions in certain cardiovascular disease (CVD) risk factors, according to the results of a meta-analysis.
5 days ago
Use of thyroid hormone therapy does not seem to protect older adults with subclinical hypothyroidism against mortality, but it appears to confer survival benefits to those aged <65 years, results of a study have shown.

High-lipid diet soon after birth slows weight loss in VLBW babies

12 Jan 2021

High doses of parenteral lipids during the first week of life eases aggressive weight loss among very low birthweight (VLBW) infants, a new study has found. This feeding regimen may also protect against extra-uterine growth restrictions (EUGR).

Researchers performed a randomized controlled trial including 83 VLBW infants who were given a lipid diet. Those in the intervention group started at a 2-g/kg per day dose of lipids, which was increased to 3 g/kg per day the next day. On the other hand, the control arm started at 0.5–1 g/kg per day of lipid, increasing gradually until reaching the max dose of 3 g/kg per day.

Infants who received the more aggressive lipid diet saw a significantly lower peak percentage weight loss during hospitalization (10.4±3.6 percent vs 12.7±4.6 percent; p=0.02). Weight at birth (p=0.89) and at 36 weeks of corrected age (p=0.11), however, did not significantly differ between arms.

Head circumference (31.3±1.5 vs 30.5±1.4 cm; p=0.05) and its corresponding z-score (–1.09±0.96 vs –1.59±0.98; p=0.04) were both also better in the intervention arm. The development of EUGR was likewise significantly attenuated in the group that received the higher lipid diet (38.6 percent vs 67.6 percent; p=0.009).

As expected, levels of triglyceride were significantly elevated in infants receiving the more aggressive diet (1.91±0.9 vs 1.49±0.5 mmol/L; p=0.007).

These differences, however, did not translate to important clinical differences. Both treatment arms saw comparable rates of hypoglycaemia in the first 7 days, stage ≥2 necrotizing enterocolitis, pulmonary hypertension, and intraventricular haemorrhage, among other such outcomes.

“VLBW infants can tolerate higher dose of parenteral lipid in the first week of age without increased risk of adverse events,” the researchers said. “A larger randomized trial is required to study effects of this regimen on brain structure, body composition, and long-term neurodevelopmental outcomes.”

Digital Edition
Asia's trusted medical magazine for healthcare professionals. Get your MIMS Doctor - Malaysia digital copy today!
Sign In To Download
Editor's Recommendations
Most Read Articles
01 Dec 2020
Tetanus toxoid 5 Lf, diphtheria toxoid 2 Lf, pertussis toxoid 2.5 mcg, filamentous haemagglutinin 5 mcg, fimbriae types 2 and 3 5 mcg, pertactin 3 mcg
Dr. Hsu Li Yang, Dr. Tan Thuan Tong, Dr. Andrea Kwa, 08 Jan 2021
Antimicrobial resistance has become increasingly dire as the rapid emergence of drug resistance, especially gram-negative pathogens, has outpaced the development of new antibiotics. At a recent virtual symposium, Dr Hsu Li Yang, Vice Dean (Global Health) and Programme Leader (Infectious Diseases), NUS Saw Swee Hock School of Public Health, presented epidemiological data on multidrug-resistant (MDR) gram-negative bacteria (GNB) in Asia, while Dr Tan Thuan Tong, Head and Senior Consultant, Department of Infectious Diseases, Singapore General Hospital (SGH), focused on the role of ceftazidime-avibactam in MDR GNB infections. Dr Andrea Kwa, Assistant Director of Research, Department of Pharmacy, SGH, joined the panel in an interactive fireside chat, to discuss challenges, practical considerations, and solutions in MDR gram-negative infections. This Pfizer-sponsored symposium was chaired by Dr Ng Shin Yi, Head and Senior Consultant of Surgical Intensive Care, SGH.
Jairia Dela Cruz, 5 days ago
Spending too much time sitting cannot be good for the body, and rising to one's feet breaks up such a behaviour and yields small, but meaningful, reductions in certain cardiovascular disease (CVD) risk factors, according to the results of a meta-analysis.
5 days ago
Use of thyroid hormone therapy does not seem to protect older adults with subclinical hypothyroidism against mortality, but it appears to confer survival benefits to those aged <65 years, results of a study have shown.