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High levels of dietary manganese up fatal heart infection

16 Oct 2017

Excessive intake of the mineral manganese can be toxic to the heart, according to a new study.

Manganese can be found in leafy vegetables such as spinach and kale as well as in pineapple, nuts, and tea.

A study in mice conducted by Dr Eric Skaar, the Ernest W. Goodpasture Professor of Pathology, Microbiology, and Immunology at the Vanderbilt University Medical Center in Nashville, Tennessee, US showed that high levels of the dietary manganese increase lethality and heart colonization by Staphylococcus aureus (S. aureus). The bacterium is also the leading cause of skin infections (eg, boils and furuncles), fatal bloodstream infections, pneumonia, as well as infective or bacterial endocarditis.

The researchers fed a group of mice with thrice the normal amount of manganese and compared with another group of mice fed with a normal diet. Most of the mice that received excessive manganese died from S. aureus infection.

The researchers put forth an explanatory mechanism for their findings, which involves the immune system’s oxidative oxygen burst. During oxidative burst, oxygen-containing molecules are rapidly released by the immune cells into the site of infection. However, excessive manganese appears to counteract this process, rendering the calprotectin ineffective at protecting the heart.

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Most Read Articles
Dr. Joseph Delano Fule Robles, 6 days ago

A recent study conducted by The University of Hong Kong (HKU) revealed that long-term use of proton pump inhibitors (PPIs) is associated with a significantly increased risk of gastric cancer even in patients who have had Helicobacter pylori eradicated. 

5 days ago
The 5-year survival rates for human papillomavirus (HPV)-associated cancers vary greatly according to age and race, with Caucasians and younger patients tending to have better survival, according to a recent US study.
6 days ago
High levels of marijuana exposure appear to not be longitudinally associated with prevalent albuminuria and substantial changes in estimated glomerular filtration rate by cystatin C (eGFRcys), a recent US epidemiological study has shown.
5 days ago
Men with breast cancer have tumours that are typically of the human epidermal growth factor receptor 2-negative Luminal B subtype and positive for oestrogen receptor, progesterone receptor and androgen receptor, according to the results of the EORTC 10085/TBCRC/BIG/NABCG International Male Breast Cancer Program study.