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Pearl Toh, 20 Nov 2019
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High hs-CRP predicts severe coronary artery disease

12 Jan 2020
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Levels of high-sensitivity C-reactive protein (hs-CRP) in the serum are predictive of more severe coronary artery disease (CAD), reports a recent study.

Researchers enrolled 10,020 CAD patients (mean age, 58±10 years; 77.0 percent male) who were divided into three subgroups according to baseline hs-CRP: 0–3 mg/L (n=6,978), 3.01–10 mg/L (n=1,997) and >10 mg/L (n=1,045). The SYNTAX score (SS) was used to evaluate disease severity and compared across the patient subgroups. The occurrence of major adverse cardiovascular events (MACEs) was also set as an outcome of interest.

Patients with higher hs-CRP levels were older, had more risk factors, were more likely to use diuretics and had more complex diseases.

Multivariate logistic regression analysis found that patients with hs-CRP levels >10 mg/L were significantly more likely to develop intermediate-to-high–SS disease (odds ratio [OR], 1.49, 95 percent confidence interval [CI], 1.21–1.84; p<0.001). Concentrations between 3.00 and 9.99 mg/L had no such effect (OR, 1.09, 95 percent CI, 0.93–1.29; p=0.295).

Other pertinent predictors were age (OR, 1.01, 95 percent CI, 1.01–1.02; p<0.001), previous episodes of myocardial infarction (OR, 1.21, 95 percent CI, 1.03–1.43; p=0.019), serum creatinine levels (OR, 1.95, 95 percent CI, 1.33–2.85; p=0.001) and left ventricular ejection fraction <45 percent (OR, 1.44, 95 percent CI, 1.07–1.95; p=0.018).

“[T]he prognostic impact of hs-CRP change needs further investigation since some medicines such as aspirin and statins could reduce its level,” said the researchers.

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Most Read Articles
Pearl Toh, 20 Nov 2019
The trade-off between the risk of ischaemic vs bleeding events may be different between Asian and non-Asian patients, which warrants careful consideration when deciding on the duration of antiplatelet therapy following a percutaneous coronary intervention (PCI), according to a presentation at ESC Asia Congress 2019.
4 days ago
Participating in a long-distance skiing event may help lower the risk of hypertension, with the number of completed races showing a weak association with the risk, a study has found.
06 Sep 2019
Hypertensive adults with lower plasma zinc concentration are at increased risk of haemorrhagic stroke, especially those with higher body mass index or lower plasma copper levels, a study has found.
06 Jan 2020
Target organ damage appears to be more noticeable in patients affected by primary aldosteronism than those affected by arterial hypertension without primary aldosteronism, suggests a study, adding that specific treatment can ease such condition.