Most Read Articles
29 Nov 2019
Metformin Extended Release 500 mg,750 mg, and 1000 mg
Pearl Toh, 2 days ago
Getting just under one extra hour of sleep per night can go a long way for the health of college students, who are often sleep-deprived, a study suggests.
29 Nov 2019
Saxagliptin 5 mg, dapagliflozin 10 mg FC tab
Roshini Claire Anthony, 6 days ago

The CA125* test could be useful at detecting ovarian cancer and various other cancers in the primary care setting, particularly for women aged >50 years, according to a study presented at the recent NCRI** Cancer Conference held in Glasgow, Scotland, UK.

High hs-CRP levels in hyperuricaemic patients linked to increased long-term CHD risk

17 Nov 2019

There appears to be a borderline positive association between high-sensitivity C-reactive protein (hs-CRP) and long-term risk of coronary heart disease (CHD) among middle-aged and elderly individuals with hyperuricaemia, a study reports.

The cross-sectional study evaluated the 10-year CHD risk in 517 hyperuricaemic patients (84.7 percent male) aged 40–85 years in relation to hs-CRP levels. Hyperuricaemia was based on uric acid concentrations: ≥416 μmol/L for males and ≥360 μmol/L for females.

In the cohort, 193 patients (37.3 percent) had relatively high 10-year CHD risk, as measured using the Framingham risk score. The crude odds ratios (ORs) associated with the highest four vs lowest quintile of serum hs-CRP level were as follows: second, 1.43 (95 percent confidence interval [CI], 0.78–2.63; p=0.245); third, 2.05 (95 percent CI, 1.14–3.67; p=0.016); fourth, 2.77 (95 percent CI, 1.54–4.98; p=0.001); and fifth, 2.12 (95 percent CI, 1.18–3.80; p=0.012; p-trend=0.057).

The results did not change significantly following adjustments for several potential confounding factors, although the associations had become only borderline significant. The respective multivariable ORs for 10-year CHD in the second, third, fourth and fifth quintiles of serum hs-CRP level were 1.40 (95 percent CI, 0.75–2.61; p=0.291), 2.05 (95 percent CI, 1.13–3.72; p=0.019), 2.69 (95 percent CI, 1.47–4.89; p=0.001) and 2.10 (95 percent CI, 1.15–3.84; p=0.016) when compared with the lowest quintile (p-trend=0.068).

Despite the need for more research, the findings suggest that hs-CRP could serve as a marker for CHD risk in patients with hyperuricaemia, according to researchers.

Digital Edition
Asia's trusted medical magazine for healthcare professionals. Get your MIMS Rheumatology digital copy today!
Sign In To Download
Editor's Recommendations
Most Read Articles
29 Nov 2019
Metformin Extended Release 500 mg,750 mg, and 1000 mg
Pearl Toh, 2 days ago
Getting just under one extra hour of sleep per night can go a long way for the health of college students, who are often sleep-deprived, a study suggests.
29 Nov 2019
Saxagliptin 5 mg, dapagliflozin 10 mg FC tab
Roshini Claire Anthony, 6 days ago

The CA125* test could be useful at detecting ovarian cancer and various other cancers in the primary care setting, particularly for women aged >50 years, according to a study presented at the recent NCRI** Cancer Conference held in Glasgow, Scotland, UK.