Most Read Articles
Roshini Claire Anthony, 11 Sep 2019

Beta-blockers could reduce mortality risk in patients with heart failure with reduced ejection fraction (HFrEF) and moderate or moderately-severe renal dysfunction without causing harm, according to the BB-META-HF* trial presented at ESC 2019.

Elvira Manzano, Yesterday

The US Preventive Services Task Force (USPSTF), in an update of its 2013 recommendations, called on clinicians to offer risk-reducing medications to women who are at increased risk for breast cancer but at low risk for adverse effects.

Pearl Toh, Yesterday
The use of SGLT-2* inhibitors was not associated with a higher risk of severe or nonsevere urinary tract infections (UTIs) in patients with type 2 diabetes (T2D) compared with DPP**-4 inhibitors or GLP-1*** receptor agonists, a population-based cohort study shows.
Stephen Padilla, 12 Sep 2019
Overweight and obesity show an inverse relationship with acne in a dose-dependent manner in young adults, according to a recent study. This suggests that the metabolically active adipose tissue plays a protective role in acne.

High homocysteine, low vitamin B12 levels seen in patients with vitiligo

23 Feb 2019

Serum homocysteine levels are higher and vitamin B12 levels lower in patients with vitiligo than in those without, reports a recent systematic review and meta-analysis.

The investigators searched online databases on 15 May 2018 to identify studies comparing serum homocysteine, folate, and vitamin B12 levels between patients with vitiligo and controls. They used a random effects model.

A total of 22 studies involving 1,448 patients with vitiligo were included in the meta-analysis. Compared with controls, patients with vitiligo were shown to have significantly greater levels of serum homocysteine (standardized mean difference [SMD], 0.550; 95 percent CI, 0.262–0.838; I2, 87.3 percent) lower vitamin B12 levels (SMD, −0.430; −0.738 to −0.121; I2, 85.3 percent).

There was no significant between-group difference in serum folate levels (SMD, –0.240; –0.592 to 0.111; I2, 85.5 percent). Furthermore, these findings were associated with disease activity as revealed by a subgroup analysis.

An earlier study by Karadag and colleagues suggested a common genetic background shared between vitiligo and vitamin B12 deficiency and hyperhomocysteinaemia. According to their findings, patients with holotranscobalamine levels in the lowest quartile had an increased risk for co-occurrence of vitiligo (p<0.005). [Clin Exp Dermatol 2012;37:62-64]

The present study has certain limitations, such as the heterogeneous nature of the studies included. Also, various factors could have influenced serum homocysteine levels, according to the investigators.

“Hyperhomocysteinaemia and folate and vitamin B12 deficiencies have been reported in patients with vitiligo. Investigating the role of these conditions might shed light on the pathogenesis of vitiligo,” the investigators noted.

Editor's Recommendations
Most Read Articles
Roshini Claire Anthony, 11 Sep 2019

Beta-blockers could reduce mortality risk in patients with heart failure with reduced ejection fraction (HFrEF) and moderate or moderately-severe renal dysfunction without causing harm, according to the BB-META-HF* trial presented at ESC 2019.

Elvira Manzano, Yesterday

The US Preventive Services Task Force (USPSTF), in an update of its 2013 recommendations, called on clinicians to offer risk-reducing medications to women who are at increased risk for breast cancer but at low risk for adverse effects.

Pearl Toh, Yesterday
The use of SGLT-2* inhibitors was not associated with a higher risk of severe or nonsevere urinary tract infections (UTIs) in patients with type 2 diabetes (T2D) compared with DPP**-4 inhibitors or GLP-1*** receptor agonists, a population-based cohort study shows.
Stephen Padilla, 12 Sep 2019
Overweight and obesity show an inverse relationship with acne in a dose-dependent manner in young adults, according to a recent study. This suggests that the metabolically active adipose tissue plays a protective role in acne.