Most Read Articles
17 Jul 2018
Higher total intake of dairy products, especially yogurt, may help reduce the risk of incident hypertension in middle-aged and older adult men and women, suggests a recent study.
19 Oct 2016
A new system called Preoperative Evaluation Clinic (PEC) workflow for cardiothoracic surgery significantly reduced the cancellation rate of elective cases at the National Heart Centre Singapore (NHCS), according to a study presented at the ASEAN Federation of Cardiology Congress (AFCC) 2016 in Yangon, Myanmar.
Pearl Toh, 19 Dec 2018
A structured cardiovascular (CV) exercise programme during adjuvant breast cancer treatment provides significant protection against decline in CV function related to chemotherapy-induced cardiotoxicity, according to the EBBA*-II trial presented at SABCS 2018, indicating that physical activity during treatment for breast cancer can benefit patients.
Rachel Soon, 31 Jan 2019

Despite increased availability of treatment options, hypertension and associated comorbidities remain a substantial public health concern, says an expert.

High HDL cholesterol levels cardioprotective in tofacitinib-treated RA patients

10 May 2019

Increases in levels of high-density lipoprotein (HDL-C) but not low-density lipoprotein (LDL-C) or total cholesterol (TC) after 24 weeks of tofacitinib treatment translate to a lower risk of future major adverse cardiovascular events (MACEs), according to a study.

Researchers conducted a posthoc analysis of six phase III trials and two long‐term extension studies over 7 years involving patients with moderately to severely active RA receiving ≥1 tofacitinib dose. Cox regression models were used to evaluate associations between baseline variables and time to first MACE following 24 weeks of tofacitinib initiation.

A total of 52 MACEs occurred over 12,873 patient‐years of exposure, with an incidence rate of 0.4 patient with events/100 patient‐years.

In univariable analyses of baseline variables, traditional cardiovascular risk factors, as well as use of corticosteroid and statin, emerged as risk factors for MACE risk in RA. No such associations were obtained for disease activity and inflammation measures.

In subsequent multivariable analyses, baseline age, hypertension and TC/HDL‐C remained significantly associated with the risk of MACE. Conversely, HDL‐C increases and TC/HDL‐C decreases after 24 weeks of tofacitinib treatment conferred a protective benefit. Changes in TC, LDL‐C and disease activity measures had no effect on MACE risk.

Finally, erythrocyte sedimentation rate increases trended with increased future MACE risk.

Researchers stressed the need for more data to further evaluate the cardiovascular safety of tofacitinib for RA.

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Most Read Articles
17 Jul 2018
Higher total intake of dairy products, especially yogurt, may help reduce the risk of incident hypertension in middle-aged and older adult men and women, suggests a recent study.
19 Oct 2016
A new system called Preoperative Evaluation Clinic (PEC) workflow for cardiothoracic surgery significantly reduced the cancellation rate of elective cases at the National Heart Centre Singapore (NHCS), according to a study presented at the ASEAN Federation of Cardiology Congress (AFCC) 2016 in Yangon, Myanmar.
Pearl Toh, 19 Dec 2018
A structured cardiovascular (CV) exercise programme during adjuvant breast cancer treatment provides significant protection against decline in CV function related to chemotherapy-induced cardiotoxicity, according to the EBBA*-II trial presented at SABCS 2018, indicating that physical activity during treatment for breast cancer can benefit patients.
Rachel Soon, 31 Jan 2019

Despite increased availability of treatment options, hypertension and associated comorbidities remain a substantial public health concern, says an expert.