Most Read Articles
Pearl Toh, 6 days ago
Every-two-month injections of the long-acting cabotegravir + rilpivirine were noninferior to once-monthly injections for virologic suppression at 48 weeks in people living with HIV*, according to the ATLAS-2M** study presented at CROI 2020 — thus providing a potential option with more convenient dosing.
Stephen Padilla, 19 Mar 2020
The assumption that children are less vulnerable to the coronavirus disease 2019 (COVID-19) compared to adults is not quite true and may even be dangerous, suggests a recent study.
22 Mar 2020
Sustained use of lopinavir-combined regimen appears to confer benefits among patients with the novel coronavirus disease (COVID-19), with improvement possibly indicated by increasing eosinophils, suggests a recent study.
24 Mar 2020
COVID-19 is a novel disease, with no existing immunity. The virus can be transmitted from person to person, quickly and exponentially. Here’s what we can do to slow down the spread, if not contain the outbreak.

High fructose intake not linked to negative metabolic effects in healthy individuals

10 Feb 2020

Prolonged ingestion of a high-dose dietary fructose does not result in relevant metabolic consequences in the presence of a stable energy intake, slightly lower body weight and potentially incomplete absorption of orally administered fructose load, according to a study.

This indicates that “young, metabolically healthy [individuals] can at least temporarily compensate for increased fructose intake,” the investigators said.

High intake of fructose led to reduced consumption of other dietary sugars and did not increase total daily energy intake. There was also no change in ectopic lipid deposition and postprandial glycogen storage in the liver and skeletal muscle.

Postprandial changes were noted in hepatic lipids (Δhepatocellular lipid [HCL]_healthy_baseline vs follow-up: −15.9±10.7 vs −6.9±4.6; p=0.17) and hepatic glycogen (Δglycogen_baseline vs follow-up: 64.4±14.1 vs 51.1±9.8; p=0.42). Myocardial function and myocardial mass remained stable.

Not surprisingly, insulin-resistant patients with nonalcoholic fatty liver disease (NAFLD) were shown to have impaired hepatic glycogen storage and increased ectopic lipid storage in the liver and skeletal muscle.

This study included 10 healthy individuals (aged 28±19 years; body mass index [BMI], 22.2±0.7 kg/m2) who underwent comprehensive metabolic phenotyping prior to and 8 weeks following a high-fructose diet (150 g daily), as well as 11 patients with NAFLD (aged 39±3.95 years; BMI, 28.4±1.25 kg/m2) as positive controls.

The investigators employed a 2-step hyperinsulinaemic euglycaemic clamp to analyse insulin sensitivity, as well as evaluated postprandial interorgan crosstalk of lipid and glucose metabolism by determining postprandial hepatic and intramyocellular lipid and glycogen accumulation using magnetic resonance spectroscopy (MRS) at 7 T. They also assessed myocardial lipid content and myocardial function via 1H MRS imaging and MRI at 3 T.

Digital Edition
Asia's trusted medical magazine for healthcare professionals. Get your MIMS Doctor - Malaysia digital copy today!
Sign In To Download
Editor's Recommendations
Most Read Articles
Pearl Toh, 6 days ago
Every-two-month injections of the long-acting cabotegravir + rilpivirine were noninferior to once-monthly injections for virologic suppression at 48 weeks in people living with HIV*, according to the ATLAS-2M** study presented at CROI 2020 — thus providing a potential option with more convenient dosing.
Stephen Padilla, 19 Mar 2020
The assumption that children are less vulnerable to the coronavirus disease 2019 (COVID-19) compared to adults is not quite true and may even be dangerous, suggests a recent study.
22 Mar 2020
Sustained use of lopinavir-combined regimen appears to confer benefits among patients with the novel coronavirus disease (COVID-19), with improvement possibly indicated by increasing eosinophils, suggests a recent study.
24 Mar 2020
COVID-19 is a novel disease, with no existing immunity. The virus can be transmitted from person to person, quickly and exponentially. Here’s what we can do to slow down the spread, if not contain the outbreak.