Most Read Articles
Roshini Claire Anthony, 11 Sep 2019

Beta-blockers could reduce mortality risk in patients with heart failure with reduced ejection fraction (HFrEF) and moderate or moderately-severe renal dysfunction without causing harm, according to the BB-META-HF* trial presented at ESC 2019.

Elvira Manzano, 4 days ago

The US Preventive Services Task Force (USPSTF), in an update of its 2013 recommendations, called on clinicians to offer risk-reducing medications to women who are at increased risk for breast cancer but at low risk for adverse effects.

Pearl Toh, 5 days ago
The use of SGLT-2* inhibitors was not associated with a higher risk of severe or nonsevere urinary tract infections (UTIs) in patients with type 2 diabetes (T2D) compared with DPP**-4 inhibitors or GLP-1*** receptor agonists, a population-based cohort study shows.
14 Sep 2019
In type 2 diabetes patients taking sulfonylureas, hypoglycaemia duration is longer at night and is inversely correlated with the level of glycated haemoglobin (HbA1c), a new study reports.

High-flow better than standard oxygen therapy for treating infants with bronchiolitis

23 Apr 2018

In the management of paediatric bronchiolitis, high-flow oxygen therapy appears to be superior to standard oxygen therapy in terms of rate of escalation of care due to treatment failure, according to the results of a trial.

A total of 1,472 infants aged <12 months who had bronchiolitis and required supplemental oxygen therapy were randomized to receive either high-flow oxygen therapy (high-flow group; n=739) or standard oxygen therapy (standard-therapy group; n=733). Infants in the standard-therapy group could receive rescue high-flow oxygen therapy in case of treatment failure.

The primary outcome was escalation of care due to treatment failure (defined as meeting ≥3 of 4 clinical criteria: persistent tachycardia, tachypnoea, hypoxemia and medical review triggered by a hospital early-warning tool). Duration of hospital stay, duration of oxygen therapy, rates of transfer to a tertiary hospital, ICU admission, intubation and adverse events were also assessed as secondary outcomes.

Significantly fewer patients in the high-flow vs standard-therapy group received escalation of care (12 percent vs 23 percent; risk difference, −11 percentage points; 95 percent CI, −15 to −7; p<0.001). On the other hand, duration of hospital stay and duration of oxygen therapy were similar between the two groups.

Pneumothorax occurred in one patient in each treatment group. Among 167 infants in the standard-therapy group who had treatment failure, 102 (61 percent) showed a response to high-flow rescue therapy.

Delivered through a nasal cannula, high-flow oxygen blends humidified and heated air with oxygen and provides a degree of positive airway pressure.

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Most Read Articles
Roshini Claire Anthony, 11 Sep 2019

Beta-blockers could reduce mortality risk in patients with heart failure with reduced ejection fraction (HFrEF) and moderate or moderately-severe renal dysfunction without causing harm, according to the BB-META-HF* trial presented at ESC 2019.

Elvira Manzano, 4 days ago

The US Preventive Services Task Force (USPSTF), in an update of its 2013 recommendations, called on clinicians to offer risk-reducing medications to women who are at increased risk for breast cancer but at low risk for adverse effects.

Pearl Toh, 5 days ago
The use of SGLT-2* inhibitors was not associated with a higher risk of severe or nonsevere urinary tract infections (UTIs) in patients with type 2 diabetes (T2D) compared with DPP**-4 inhibitors or GLP-1*** receptor agonists, a population-based cohort study shows.
14 Sep 2019
In type 2 diabetes patients taking sulfonylureas, hypoglycaemia duration is longer at night and is inversely correlated with the level of glycated haemoglobin (HbA1c), a new study reports.