Most Read Articles
Roshini Claire Anthony, 10 Jan 2020

The rates of ovarian cancer in Singapore have more than doubled over the past 40 years, with evidence of variation between the main ethnic groups, a recent study has shown.

Pearl Toh, 4 days ago
Pregnant women with inadequate knowledge on health are more likely to have undesirable maternal outcomes during delivery and adverse outcomes in their offspring than those who were well informed, according to a large cohort study presented at SMFM 2020 Annual Pregnancy Meeting.
01 Sep 2018

Gangliosides and docosahexaenoic acid (DHA) play critical roles in early childhood brain development. 

29 Jan 2020
The risk of adverse pregnancy outcomes appears to be low in women treated with vedolizumab for inflammatory bowel disease, a study has found.

High ferritin linked to gestational diabetes mellitus

18 Nov 2019

There appears to be a direct correlation between ferritin concentrations and the risk of gestational diabetes mellitus (GDM), reports a new meta-analysis.

Accessing the databases of PubMed, the Cochrane Library, Embase and Web of Science, researchers retrieved 10 observational studies corresponding to 4,690 participants. Most of the participants (n=3,650) were euglycaemic; the remaining 1,040 had GDM. Seven of the included studies scored at least 6 on the Newcastle-Ottawa Scale.

Women in the topmost category of ferritin concentrations were significantly more likely to develop GDM than their counterparts in the lowest category (summarized relative risk [SRR], 1.87, 95 percent confidence interval [CI], 1.50–2.34). Heterogeneity of evidence was null (p=0.26).

Four studies were eligible for the analysis of a dose-response relationship. Meta-analysis revealed that an increase in ferritin of 10 µg/L led to a corresponding 8-percent jump in the likelihood of developing GDM (SRR, 1.08, 95 percent CI, 1.05–1.13; p<0.01). Heterogeneity was high and of borderline significance (p=0.08).

Stratifying according to whether ferritin was measured from the plasma or serum, meta-analysis found that plasma ferritin (SRR, 2.51, 95 percent CI, 1.64–3.86) appeared to play a bigger role in GDM risk than serum ferritin (SRR, 1.63, 95 percent CI, 1.33–2.15).

The risk elevation likewise remained significant even when measurements were made during the first (SRR, 2.05, 95 percent CI, 1.39–3.02) or second (SRR, 1.79, 95 percent CI, 1.36–2.36) trimesters.

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Most Read Articles
Roshini Claire Anthony, 10 Jan 2020

The rates of ovarian cancer in Singapore have more than doubled over the past 40 years, with evidence of variation between the main ethnic groups, a recent study has shown.

Pearl Toh, 4 days ago
Pregnant women with inadequate knowledge on health are more likely to have undesirable maternal outcomes during delivery and adverse outcomes in their offspring than those who were well informed, according to a large cohort study presented at SMFM 2020 Annual Pregnancy Meeting.
01 Sep 2018

Gangliosides and docosahexaenoic acid (DHA) play critical roles in early childhood brain development. 

29 Jan 2020
The risk of adverse pregnancy outcomes appears to be low in women treated with vedolizumab for inflammatory bowel disease, a study has found.