High fatty acid binding protein 4 predicts pre-eclampsia
High fatty acid binding protein 4 (FABP4) concentrations during the first prenatal visit is an independent predictor of pre-eclampsia, a recent study has shown.
Using enzyme-linked immunosorbent assays, researchers measured serum FABP4 levels in 1,486 women in early pregnancy (median age 28.0 years). Sixty-one of the participants developed pre-eclampsia, yielding an incidence rate of 4.1 percent.
Median FABP4 concentrations measured during the first prenatal visit were significantly higher in participants who eventually developed pre-eclampsia than in those who did not (24.8 vs 15.6 ng/mL; p<0.001). Moreover, the incidence rate increased along with quartiles of FABP4 levels (Q1: 1.3 percent; Q2: 2.7 percent; Q3: 4.8 percent; Q4: 7.5 percent).
Multivariate logistic regression models provided further confirmation of these findings. For each unit increase in FABP4, there was a 4-percent corresponding increase in the risk of pre-eclampsia (adjusted odds ratio [OR], 1.04; 94 percent CI, 1.02–1.07; p=0.015) and a 9-percent increase in the likelihood of severe pre-eclampsia (adjusted OR, 1.09; 1.04–1.16; p=0.004).
Comparing FABP4 quartiles yielded a similar trend. Relative to quartile 1, those in quartiles 3 (adjusted OR, 2.21; 1.09–4.18) and 4 (adjusted OR, 3.05; 1.43–7.75) were at significantly higher risks of developing pre-eclampsia. No such effect was observed for quartile 2 (adjusted OR, 1.18; 0.47–4.13).
Notably, even when compared against quartiles 1–3 together, the fourth quartile of FABP4 was significantly prognostic of pre-eclampsia (OR, 2.07; 1.06–3.98; p=0.009).