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High fatty acid binding protein 4 predicts pre-eclampsia

10 Sep 2018
The study reaffirms that low-dose aspirin can be considered as a prophylactic of preterm delivery for women at high risk of preeclampsia

High fatty acid binding protein 4 (FABP4) concentrations during the first prenatal visit is an independent predictor of pre-eclampsia, a recent study has shown.

Using enzyme-linked immunosorbent assays, researchers measured serum FABP4 levels in 1,486 women in early pregnancy (median age 28.0 years). Sixty-one of the participants developed pre-eclampsia, yielding an incidence rate of 4.1 percent.

Median FABP4 concentrations measured during the first prenatal visit were significantly higher in participants who eventually developed pre-eclampsia than in those who did not (24.8 vs 15.6 ng/mL; p<0.001). Moreover, the incidence rate increased along with quartiles of FABP4 levels (Q1: 1.3 percent; Q2: 2.7 percent; Q3: 4.8 percent; Q4: 7.5 percent).

Multivariate logistic regression models provided further confirmation of these findings. For each unit increase in FABP4, there was a 4-percent corresponding increase in the risk of pre-eclampsia (adjusted odds ratio [OR], 1.04; 94 percent CI, 1.02–1.07; p=0.015) and a 9-percent increase in the likelihood of severe pre-eclampsia (adjusted OR, 1.09; 1.04–1.16; p=0.004).

Comparing FABP4 quartiles yielded a similar trend. Relative to quartile 1, those in quartiles 3 (adjusted OR, 2.21; 1.09–4.18) and 4 (adjusted OR, 3.05; 1.43–7.75) were at significantly higher risks of developing pre-eclampsia. No such effect was observed for quartile 2 (adjusted OR, 1.18; 0.47–4.13).

Notably, even when compared against quartiles 1–3 together, the fourth quartile of FABP4 was significantly prognostic of pre-eclampsia (OR, 2.07; 1.06–3.98; p=0.009).

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Most Read Articles
Roshini Claire Anthony, 5 days ago

Patients with mild hypertension who are at low risk for cardiovascular disease (CVD) do not appear to derive mortality or CVD benefit from antihypertensive treatments, raising questions on the need for treatment in this population, according to a recent study from England.

Pearl Toh, 09 Nov 2018
A personalized computerized neurofeedback intervention for training attention and memory shows potential in cognitive training for healthy elderly men, who improved in cognitive performance after the training, although no significant improvements were seen in the overall study population.
3 days ago
Type 1 diabetes impairs cognitive functioning in children, and this effect is exacerbated by extreme glycaemic levels, according to a recent meta-analysis.
Pearl Toh, 08 Nov 2018
The pneumonia-causing bacteria, Streptococcus pneumoniae (pneumococcus), can be spread through nose picking and rubbing after exposure of the hands to the bacteria — in addition to the conventionally known route of inhalation of airborne droplets, a study reveals.