Most Read Articles
Roshini Claire Anthony, 04 Apr 2019

In addition to an intensive weight loss programme, the use of continuous positive airway pressure (CPAP) could improve absolute weight loss in individuals with obesity and obstructive sleep apnoea (OSA), according to a study presented at ENDO 2019.

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The ketogenic and Modified Atkin’s diets are effective treatments for children with refractory epilepsy of genetic aetiology, a new study suggests.
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Long-acting beta2-agonist (LABA) plus long-acting muscarinic antagonist (LAMA) combinations compare with inhalers containing both LABA and corticosteroid (LABA-ICS) in terms of reducing chronic obstructive pulmonary disease (COPD) exacerbations, although the LAMA-LABA combination is more favourable as it is associated with fewer episodes of severe pneumonia, according to a study.
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High fatty acid binding protein 4 predicts pre-eclampsia

10 Sep 2018
The study reaffirms that low-dose aspirin can be considered as a prophylactic of preterm delivery for women at high risk of preeclampsia

High fatty acid binding protein 4 (FABP4) concentrations during the first prenatal visit is an independent predictor of pre-eclampsia, a recent study has shown.

Using enzyme-linked immunosorbent assays, researchers measured serum FABP4 levels in 1,486 women in early pregnancy (median age 28.0 years). Sixty-one of the participants developed pre-eclampsia, yielding an incidence rate of 4.1 percent.

Median FABP4 concentrations measured during the first prenatal visit were significantly higher in participants who eventually developed pre-eclampsia than in those who did not (24.8 vs 15.6 ng/mL; p<0.001). Moreover, the incidence rate increased along with quartiles of FABP4 levels (Q1: 1.3 percent; Q2: 2.7 percent; Q3: 4.8 percent; Q4: 7.5 percent).

Multivariate logistic regression models provided further confirmation of these findings. For each unit increase in FABP4, there was a 4-percent corresponding increase in the risk of pre-eclampsia (adjusted odds ratio [OR], 1.04; 94 percent CI, 1.02–1.07; p=0.015) and a 9-percent increase in the likelihood of severe pre-eclampsia (adjusted OR, 1.09; 1.04–1.16; p=0.004).

Comparing FABP4 quartiles yielded a similar trend. Relative to quartile 1, those in quartiles 3 (adjusted OR, 2.21; 1.09–4.18) and 4 (adjusted OR, 3.05; 1.43–7.75) were at significantly higher risks of developing pre-eclampsia. No such effect was observed for quartile 2 (adjusted OR, 1.18; 0.47–4.13).

Notably, even when compared against quartiles 1–3 together, the fourth quartile of FABP4 was significantly prognostic of pre-eclampsia (OR, 2.07; 1.06–3.98; p=0.009).

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Most Read Articles
Roshini Claire Anthony, 04 Apr 2019

In addition to an intensive weight loss programme, the use of continuous positive airway pressure (CPAP) could improve absolute weight loss in individuals with obesity and obstructive sleep apnoea (OSA), according to a study presented at ENDO 2019.

2 days ago
The ketogenic and Modified Atkin’s diets are effective treatments for children with refractory epilepsy of genetic aetiology, a new study suggests.
12 Apr 2019
Long-acting beta2-agonist (LABA) plus long-acting muscarinic antagonist (LAMA) combinations compare with inhalers containing both LABA and corticosteroid (LABA-ICS) in terms of reducing chronic obstructive pulmonary disease (COPD) exacerbations, although the LAMA-LABA combination is more favourable as it is associated with fewer episodes of severe pneumonia, according to a study.
3 days ago
Extremely premature neonates who have been exposed to pre-eclampsia in utero are at high risk of developing severe respiratory distress syndrome and severe bronchopulmonary dysplasia, according to a study.