Most Read Articles
2 days ago
No association exists between physical activity and the risk of urological cancer, according to a population-based prospective study in Japan.
12 Feb 2019
Olanzapine confers a modest therapeutic effect on weight compared with placebo in adult outpatients with anorexia nervosa, a study has shown. However, it does not appear to offer significant benefit for psychological symptoms.
3 days ago
Patients with childhood-onset inflammatory bowel disease are more likely to die than the general population, a study suggests.
3 days ago
Reduced caloric intake results in a significant improvement in glucose metabolism and body-fat composition, including liver-fat content, according to a study. Changes in ferritin levels appear to mediate the striking reduction in liver fat.

High fatty acid binding protein 4 predicts pre-eclampsia

10 Sep 2018
The study reaffirms that low-dose aspirin can be considered as a prophylactic of preterm delivery for women at high risk of preeclampsia

High fatty acid binding protein 4 (FABP4) concentrations during the first prenatal visit is an independent predictor of pre-eclampsia, a recent study has shown.

Using enzyme-linked immunosorbent assays, researchers measured serum FABP4 levels in 1,486 women in early pregnancy (median age 28.0 years). Sixty-one of the participants developed pre-eclampsia, yielding an incidence rate of 4.1 percent.

Median FABP4 concentrations measured during the first prenatal visit were significantly higher in participants who eventually developed pre-eclampsia than in those who did not (24.8 vs 15.6 ng/mL; p<0.001). Moreover, the incidence rate increased along with quartiles of FABP4 levels (Q1: 1.3 percent; Q2: 2.7 percent; Q3: 4.8 percent; Q4: 7.5 percent).

Multivariate logistic regression models provided further confirmation of these findings. For each unit increase in FABP4, there was a 4-percent corresponding increase in the risk of pre-eclampsia (adjusted odds ratio [OR], 1.04; 94 percent CI, 1.02–1.07; p=0.015) and a 9-percent increase in the likelihood of severe pre-eclampsia (adjusted OR, 1.09; 1.04–1.16; p=0.004).

Comparing FABP4 quartiles yielded a similar trend. Relative to quartile 1, those in quartiles 3 (adjusted OR, 2.21; 1.09–4.18) and 4 (adjusted OR, 3.05; 1.43–7.75) were at significantly higher risks of developing pre-eclampsia. No such effect was observed for quartile 2 (adjusted OR, 1.18; 0.47–4.13).

Notably, even when compared against quartiles 1–3 together, the fourth quartile of FABP4 was significantly prognostic of pre-eclampsia (OR, 2.07; 1.06–3.98; p=0.009).

Digital Edition
Asia's trusted medical magazine for healthcare professionals. Get your MIMS Doctor - Malaysia digital copy today!
Sign In To Download
Editor's Recommendations
Most Read Articles
2 days ago
No association exists between physical activity and the risk of urological cancer, according to a population-based prospective study in Japan.
12 Feb 2019
Olanzapine confers a modest therapeutic effect on weight compared with placebo in adult outpatients with anorexia nervosa, a study has shown. However, it does not appear to offer significant benefit for psychological symptoms.
3 days ago
Patients with childhood-onset inflammatory bowel disease are more likely to die than the general population, a study suggests.
3 days ago
Reduced caloric intake results in a significant improvement in glucose metabolism and body-fat composition, including liver-fat content, according to a study. Changes in ferritin levels appear to mediate the striking reduction in liver fat.