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High-fat diet plus fructose, but not glucose, increases hepatic fat content

05 Jun 2019

There appears to be a varying immediate impact of fructose and glucose on hepatic fat content (HFC) in humans in vivo, results of a recent study have shown.

Participants who consumed a high-fat load alone or a high-fat load with fructose increased their HFC to 119±19 percent (p<0.05) and 117±17 percent (p<0.01) of baseline, respectively. On the other hand, coadministration of glucose with a high-fat load did not affect HFC.

Furthermore, fasting or consuming repeated doses of fructose did not have any impact on HFC. When participants were administered three doses of glucose, HFC decreased to 85±13 percent (p<0.05) of baseline.

In this study, the investigators explored how the administration of high-fat load, glucose, fructose and combination thereof affected HFC measured in vivo using proton magnetic resonance spectroscopy (1H-MRS) in healthy individuals.

A total of 10 nonsteatotic male volunteers (mean age, 38.5±9.6 years; mean body mass index, 26.9±2.7 kg/m2) participated randomly in six experiments that lasted 8 hours each: fasting; a high-fat load, 150 g of fat (dairy cream) at time 0; glucose, three doses of 50 g at 0, 2 and 4 hours; a high-fat load with glucose; fructose, three doses of 50 g at 0, 2 and 4 hours; and a high-fat load with fructose.

1H-MRS was used to measure HFC prior to test meal administration (before time 0) and at 3 and 6 hours. Glucose, insulin, nonesterified fatty acids and plasma concentrations of triglycerides were monitored throughout each experiment.

“Diets rich in fat and added sugars (especially fructose) play an important role in the pathogenesis of nonalcoholic liver disease, but there is only limited information on the acute effects of these nutrients on HFC,” the investigators said.

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Most Read Articles
6 days ago
In patients with type 2 diabetes, obesity may be protective against vision-threatening diabetic retinopathy, a recent Korea study has shown.
Yesterday
The aromatase inhibitor anastrozole shows promise in the treatment of children with congenital adrenal hyperplasia, reducing bone age advancement without adversely affecting bone mineral density and visceral adipose tissue, as shown in a recent study.
Roshini Claire Anthony, 5 days ago

Men with metastatic hormone-sensitive prostate cancer (mHSPC) who receive testosterone suppression therapy may have a better survival outcome with the addition of enzalutamide over other non-steroidal anti-androgen (NSAA) therapies, according to the phase III ENZAMET* trial.

5 days ago
The use of opioids may have limited long-term efficacy in the management of chronic noncancer pain, reports a new study.