Most Read Articles
Roshini Claire Anthony, 11 Sep 2019

Beta-blockers could reduce mortality risk in patients with heart failure with reduced ejection fraction (HFrEF) and moderate or moderately-severe renal dysfunction without causing harm, according to the BB-META-HF* trial presented at ESC 2019.

Elvira Manzano, 2 days ago

The US Preventive Services Task Force (USPSTF), in an update of its 2013 recommendations, called on clinicians to offer risk-reducing medications to women who are at increased risk for breast cancer but at low risk for adverse effects.

Pearl Toh, 3 days ago
The use of SGLT-2* inhibitors was not associated with a higher risk of severe or nonsevere urinary tract infections (UTIs) in patients with type 2 diabetes (T2D) compared with DPP**-4 inhibitors or GLP-1*** receptor agonists, a population-based cohort study shows.
14 Sep 2019
In type 2 diabetes patients taking sulfonylureas, hypoglycaemia duration is longer at night and is inversely correlated with the level of glycated haemoglobin (HbA1c), a new study reports.

High-fat diet plus fructose, but not glucose, increases hepatic fat content

05 Jun 2019

There appears to be a varying immediate impact of fructose and glucose on hepatic fat content (HFC) in humans in vivo, results of a recent study have shown.

Participants who consumed a high-fat load alone or a high-fat load with fructose increased their HFC to 119±19 percent (p<0.05) and 117±17 percent (p<0.01) of baseline, respectively. On the other hand, coadministration of glucose with a high-fat load did not affect HFC.

Furthermore, fasting or consuming repeated doses of fructose did not have any impact on HFC. When participants were administered three doses of glucose, HFC decreased to 85±13 percent (p<0.05) of baseline.

In this study, the investigators explored how the administration of high-fat load, glucose, fructose and combination thereof affected HFC measured in vivo using proton magnetic resonance spectroscopy (1H-MRS) in healthy individuals.

A total of 10 nonsteatotic male volunteers (mean age, 38.5±9.6 years; mean body mass index, 26.9±2.7 kg/m2) participated randomly in six experiments that lasted 8 hours each: fasting; a high-fat load, 150 g of fat (dairy cream) at time 0; glucose, three doses of 50 g at 0, 2 and 4 hours; a high-fat load with glucose; fructose, three doses of 50 g at 0, 2 and 4 hours; and a high-fat load with fructose.

1H-MRS was used to measure HFC prior to test meal administration (before time 0) and at 3 and 6 hours. Glucose, insulin, nonesterified fatty acids and plasma concentrations of triglycerides were monitored throughout each experiment.

“Diets rich in fat and added sugars (especially fructose) play an important role in the pathogenesis of nonalcoholic liver disease, but there is only limited information on the acute effects of these nutrients on HFC,” the investigators said.

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Most Read Articles
Roshini Claire Anthony, 11 Sep 2019

Beta-blockers could reduce mortality risk in patients with heart failure with reduced ejection fraction (HFrEF) and moderate or moderately-severe renal dysfunction without causing harm, according to the BB-META-HF* trial presented at ESC 2019.

Elvira Manzano, 2 days ago

The US Preventive Services Task Force (USPSTF), in an update of its 2013 recommendations, called on clinicians to offer risk-reducing medications to women who are at increased risk for breast cancer but at low risk for adverse effects.

Pearl Toh, 3 days ago
The use of SGLT-2* inhibitors was not associated with a higher risk of severe or nonsevere urinary tract infections (UTIs) in patients with type 2 diabetes (T2D) compared with DPP**-4 inhibitors or GLP-1*** receptor agonists, a population-based cohort study shows.
14 Sep 2019
In type 2 diabetes patients taking sulfonylureas, hypoglycaemia duration is longer at night and is inversely correlated with the level of glycated haemoglobin (HbA1c), a new study reports.