Most Read Articles
15 Feb 2020
A new noninvasive risk score―incorporating factors such as waist circumference, age, sex, and histories of hyperglycaemia and diabetes in the family― reliably identifies those at high dysglycaemia risk, reports a new Saudi Arabia study.
Yesterday
There appears to be no association between aortic pulse wave velocity, a measure of vascular stiffness, and migraine, as reported in a recent study.
29 Nov 2019
Metformin Extended Release 500 mg,750 mg, and 1000 mg
01 Dec 2019
Pneumonia is a common infection– affecting around 3,200 people inSingapore in 2016 – making it the thirdmost common cause of hospitalisation inthe country. Its common complications,especially with delayed or inappropriatetreatment, include bacteraemia andseptic shock, lung abscesses, pleuraleffusions, empyema, pleurisy, respiratoryfailure and renal failure.

High-dose vitamin D supplementation fails to prevent respiratory infection in seniors

11 Sep 2019

Monthly supplementation with high-dose vitamin D does little to stave off the risk of developing acute respiratory infection (ARI) in older adults with low prevalence of profound vitamin D deficiency, a study has found.

Researchers randomized 5,110 adults aged 50–84 years (mean age, 66 years; 58 percent male; 83 percent of European/other descent) to receive an initial oral dose of 200,000 IU vitamin D3 followed by 100,000 IU monthly (n=2,558) or placebo (n=2,552) for a median of 1.6 years. Participants completed monthly questionnaires to report upper and lower ARIs.

Mean (SD) baseline blood 25-hydroxyvitamin D (25OHD) level was 63 nmol/L, with 25 percent of participants having <50 nmol/L. In a random sample of 441 individuals, mean 25OHD levels increased to 135 nmol/L with vitamin D supplementation at 3 years, but remained stable at 63 nmol/L with placebo.

During follow-up, at least one ARI occurred in 3,737 participants: 74.1 percent in the vitamin D group vs 73.7 percent in the placebo group. The difference in ARI risk was not significant between the two groups (hazard ratio, 1.01, 95 percent CI, 0.94–1.07).

Similar results were seen in most subgroups, including that defined by baseline 25OHD <50 nmol/L, and in analyses of the upper/lower components of the ARI outcome.

In light of the findings, the researchers do not recommend monthly dosing of vitamin D for the prevention of ARI.

Digital Edition
Asia's trusted medical magazine for healthcare professionals. Get your MIMS Doctor - Malaysia digital copy today!
Sign In To Download
Editor's Recommendations
Most Read Articles
15 Feb 2020
A new noninvasive risk score―incorporating factors such as waist circumference, age, sex, and histories of hyperglycaemia and diabetes in the family― reliably identifies those at high dysglycaemia risk, reports a new Saudi Arabia study.
Yesterday
There appears to be no association between aortic pulse wave velocity, a measure of vascular stiffness, and migraine, as reported in a recent study.
29 Nov 2019
Metformin Extended Release 500 mg,750 mg, and 1000 mg
01 Dec 2019
Pneumonia is a common infection– affecting around 3,200 people inSingapore in 2016 – making it the thirdmost common cause of hospitalisation inthe country. Its common complications,especially with delayed or inappropriatetreatment, include bacteraemia andseptic shock, lung abscesses, pleuraleffusions, empyema, pleurisy, respiratoryfailure and renal failure.