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High-dose vitamin D supplementation fails to prevent respiratory infection in seniors

11 Sep 2019

Monthly supplementation with high-dose vitamin D does little to stave off the risk of developing acute respiratory infection (ARI) in older adults with low prevalence of profound vitamin D deficiency, a study has found.

Researchers randomized 5,110 adults aged 50–84 years (mean age, 66 years; 58 percent male; 83 percent of European/other descent) to receive an initial oral dose of 200,000 IU vitamin D3 followed by 100,000 IU monthly (n=2,558) or placebo (n=2,552) for a median of 1.6 years. Participants completed monthly questionnaires to report upper and lower ARIs.

Mean (SD) baseline blood 25-hydroxyvitamin D (25OHD) level was 63 nmol/L, with 25 percent of participants having <50 nmol/L. In a random sample of 441 individuals, mean 25OHD levels increased to 135 nmol/L with vitamin D supplementation at 3 years, but remained stable at 63 nmol/L with placebo.

During follow-up, at least one ARI occurred in 3,737 participants: 74.1 percent in the vitamin D group vs 73.7 percent in the placebo group. The difference in ARI risk was not significant between the two groups (hazard ratio, 1.01, 95 percent CI, 0.94–1.07).

Similar results were seen in most subgroups, including that defined by baseline 25OHD <50 nmol/L, and in analyses of the upper/lower components of the ARI outcome.

In light of the findings, the researchers do not recommend monthly dosing of vitamin D for the prevention of ARI.

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Most Read Articles
6 days ago
Immobilization or disuse of the forearm leads to impairment in the ability of a protein-rich meal to promote positive muscle amino acid balance, which is aggravated by dietary lipid oversupply, suggests a study. Disuse also lowers postprandial forearm amino acid uptake, but this is not exacerbated under high-fat conditions.
18 May 2020
Glucagon-like peptide-1 receptor agonists (GLP-1RA) are more effective than basal insulin in the management of total (TC) and low-density lipoprotein cholesterol (LDL-C), reveals a recent study.
17 May 2020
Increased coffee consumption among regular drinkers is associated with higher estimated glomerular filtration rate and confers protection against the risk of chronic kidney disease stages G3–G5 and albuminuria, as shown in a study.
Jairia Dela Cruz, 16 May 2020
Excess weight, greater abdominal fat, inflammation and low physical performance can all contribute to insulin resistance in middle-age Singaporean women, and these variables explain why the condition is more common among women of Chinese than Malay and Indian ethnicities, a study has found.