Most Read Articles
3 days ago
Older women with longer endogenous oestrogen exposure and hormone therapy use are at much higher odds of having favourable cognitive status in late life, a recent study suggests.
Elvira Manzano, 2 days ago
Supplementation with omega-3 fatty acids or vitamin D3 for up to 5 years has no effect on kidney function in adults with type 2 diabetes (T2D), the VITAL-DKD* ancillary study has shown.
3 days ago
Better sleep appears to weaken pain and fatigue in older, community-dwelling adults with hip or knee osteoarthritis (OA), reports a recent study.
07 Nov 2019
Maribavir 400 mg twice daily appears to have comparable efficacy to valganciclovir at clearing cytomegalovirus viraemia in transplant recipients, a study has found.

High-dose vitamin D supplementation fails to prevent respiratory infection in seniors

11 Sep 2019

Monthly supplementation with high-dose vitamin D does little to stave off the risk of developing acute respiratory infection (ARI) in older adults with low prevalence of profound vitamin D deficiency, a study has found.

Researchers randomized 5,110 adults aged 50–84 years (mean age, 66 years; 58 percent male; 83 percent of European/other descent) to receive an initial oral dose of 200,000 IU vitamin D3 followed by 100,000 IU monthly (n=2,558) or placebo (n=2,552) for a median of 1.6 years. Participants completed monthly questionnaires to report upper and lower ARIs.

Mean (SD) baseline blood 25-hydroxyvitamin D (25OHD) level was 63 nmol/L, with 25 percent of participants having <50 nmol/L. In a random sample of 441 individuals, mean 25OHD levels increased to 135 nmol/L with vitamin D supplementation at 3 years, but remained stable at 63 nmol/L with placebo.

During follow-up, at least one ARI occurred in 3,737 participants: 74.1 percent in the vitamin D group vs 73.7 percent in the placebo group. The difference in ARI risk was not significant between the two groups (hazard ratio, 1.01, 95 percent CI, 0.94–1.07).

Similar results were seen in most subgroups, including that defined by baseline 25OHD <50 nmol/L, and in analyses of the upper/lower components of the ARI outcome.

In light of the findings, the researchers do not recommend monthly dosing of vitamin D for the prevention of ARI.

Digital Edition
Asia's trusted medical magazine for healthcare professionals. Get your MIMS Doctor - Malaysia digital copy today!
Sign In To Download
Editor's Recommendations
Most Read Articles
3 days ago
Older women with longer endogenous oestrogen exposure and hormone therapy use are at much higher odds of having favourable cognitive status in late life, a recent study suggests.
Elvira Manzano, 2 days ago
Supplementation with omega-3 fatty acids or vitamin D3 for up to 5 years has no effect on kidney function in adults with type 2 diabetes (T2D), the VITAL-DKD* ancillary study has shown.
3 days ago
Better sleep appears to weaken pain and fatigue in older, community-dwelling adults with hip or knee osteoarthritis (OA), reports a recent study.
07 Nov 2019
Maribavir 400 mg twice daily appears to have comparable efficacy to valganciclovir at clearing cytomegalovirus viraemia in transplant recipients, a study has found.