Most Read Articles
Joyce Lam Ching Mei, 28 Mar 2019
April 17 marks World Haemophilia Day, and this year’s theme is  “Reaching Out – The First Step to Care”. Adjunct Assoc Prof Joyce Lam Ching Mei, head of the Haematology Laboratory and Blood Bank and senior consultant from the Paediatric Haematology/Oncology Service at KK Women’s and Children’s Hospital, Singapore, speaks to Elaine Soliven on the importance of recognizing and managing bleeding disorders in primary care.
02 Apr 2019
Using preventive zinc and micronutrient powder supplementation does not appear to improve growth in children, a recent study has found.
Pearl Toh, 01 May 2019
Preterm infants with very low birth weight (VLBW) who were breastfed have significantly higher levels of metabolites important for brain growth and development in their brain tissue compared with formula-fed infants, suggesting that breastfed infants have improved cerebral metabolism at term-equivalent age, according to a study presented at the PAS 2019 Meeting.

High-dose vitamin D does not prevent allergic disease in newborns

03 Jun 2019

High-dose vitamin D supplementation does not protect against allergic disease, allergic sensitization or diseases during the first year of life, a recent study reports.

Researchers randomly assigned 975 infants to receive either 10 µg (n=489) or 30 µg (n=486) supplementation starting at 2 weeks of age. Food and aeroallergen immunoglobulin E levels, as well as the manifestation of wheezing and allergic diseases, were assessed at 12 months of age.

Serum samples available for analysis were obtained from 723 infants. Sensitization to food allergens and aeroallergens was detected in 15.8 percent (n=114) and 3.5 percent (n=25), respectively. Sensitization to food was significantly more likely to occur in children born to parents with a history of allergic disease (odds ratio [OR], 1.16, 95 percent CI, 1.02–1.33).

The rates of food allergen (15.9 percent vs 15.6 percent; p=0.910; OR, 0.98, 0.66–1.46) and aeroallergen (3.9 percent vs 3.0 percent; p=0.509; OR, 0.76, 0.34–1.71) were comparable among participants who received the 10-µg and 30-µg vitamin D supplement.

Data on allergic diseases and symptoms were available for 770 children at 12 months. Physician diagnoses of wheat (1.3 percent vs 1.6 percent; p=0.77; OR, 1.18, 0.36–3.89) and food allergy (5.2 percent vs 7.0 percent; p=0.318; OR, 1.35, 0.75–2.46), atopic eczema (18.9 percent vs 14.4 percent; p=0.097; OR, 0.72, 0.49–1.01), or asthma (0.3 percent vs 0 percent; p=0.494) were comparable between the 10-µg and 30-µg vitamin D groups.

The same was true for wheezing (10 µg vs 30 µg: 10.3 percent vs 9.7 percent; p=0.781; OR, 0.94, 0.58–1.50), hospitalization for bronchiolitis or wheezing (3.1 percent vs 2.4 percent; p=0.547; OR, 0.78, 0.35–1.74), persistent coughs (5.3 percent vs 6.9 percent; p=0.371; OR, 1.32, 0.72–2.40), or itchy rash (18.9 percent vs 16.5 percent; p=0.067; OR, 0.70, 0.48–1.03).

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Most Read Articles
Joyce Lam Ching Mei, 28 Mar 2019
April 17 marks World Haemophilia Day, and this year’s theme is  “Reaching Out – The First Step to Care”. Adjunct Assoc Prof Joyce Lam Ching Mei, head of the Haematology Laboratory and Blood Bank and senior consultant from the Paediatric Haematology/Oncology Service at KK Women’s and Children’s Hospital, Singapore, speaks to Elaine Soliven on the importance of recognizing and managing bleeding disorders in primary care.
02 Apr 2019
Using preventive zinc and micronutrient powder supplementation does not appear to improve growth in children, a recent study has found.
Pearl Toh, 01 May 2019
Preterm infants with very low birth weight (VLBW) who were breastfed have significantly higher levels of metabolites important for brain growth and development in their brain tissue compared with formula-fed infants, suggesting that breastfed infants have improved cerebral metabolism at term-equivalent age, according to a study presented at the PAS 2019 Meeting.