Most Read Articles
Jairia Dela Cruz, 22 Aug 2018
Fast food consumption appears to be detrimental to health, with hamburgers having been shown to have a dose-response association with the risk of asthma.
Roshini Claire Anthony, 05 Sep 2018

Patients admitted to the intensive care unit (ICU) with severe influenza have an elevated risk of developing invasive pulmonary aspergillosis, particularly if they are immunocompromised at time of admission, a recent study has shown.

Radha Chitale, 06 Apr 2016
An investigational device monitoring fluid accumulation in the lungs significantly reduced hospitalization due to heart failure and death by any cause among heart failure patients compared with standard monitoring and treatment methods, according to results from the IMPEDANCE-HF trial reported during the recent ACC meeting in Chicago, Illinois, US.

High-dose rifampin may help shorten tuberculosis treatment

08 Jul 2018
There were approximately 36 cases of TB per 100,000 population in Singapore last year

Higher doses of rifampin result in more rapid sputum sterilization and similar toxicity, a study has shown. These findings support the investigation of increased rifampin doses to shorten tuberculosis treatment.

To determine whether increased rifampin doses could shorten standard therapy for tuberculosis without increased toxicity, the investigators conducted a blinded, randomized, controlled phase II clinical trial involving 180 adults with new smear-positive pulmonary tuberculosis, susceptible to isoniazid and rifampin. Participants were randomized 1:1:1 to 10, 15 and 20 mg/kg/day of rifampin during the intensive phase.

The primary efficacy and safety endpoints were as follows: change in elimination rate of M. tuberculosis log10 colony forming units and frequency of grade 2 rifampin related adverse events (AEs). Efficacy by treatment arm and by primary (AUC/MIC) and secondary (AUC) pharmacokinetic exposure was also reported.

Differences of –0.011 (95 percent CI, –0.025 to 0.002; p=0.230) and –0.022 (–0.046 to –0.002; p=0.022) log10 colony forming units/mL/day were recorded in the modified intention-to-treat and per-protocol analyses, respectively, for every 5 mg/kg/day increase in rifampin dose. In the per-protocol group, elimination rate significantly increased with rifampin AUC0-6 (p=0.011) but not with AUC0-6/MIC99.9 (p=0.053).

Occurrence of grade 2 rifampin-related AEs showed similar frequency across the three treatment arms: 26 (43.3 percent), 31 (51.7 percent) and 23 (38.3 percent) participants in the 10, 15 and 20 mg/kg/day rifampin dose groups, respectively, had at least one AE (p=0.7092) up to 4 weeks after the intensive phase. In addition, 11 (6.1 percent) participants had treatment failure or disease recurrence.

Digital Edition
Asia's trusted medical magazine for healthcare professionals. Get your MIMS Respirology - Malaysia digital copy today!
Sign In To Download
Editor's Recommendations
Most Read Articles
Jairia Dela Cruz, 22 Aug 2018
Fast food consumption appears to be detrimental to health, with hamburgers having been shown to have a dose-response association with the risk of asthma.
Roshini Claire Anthony, 05 Sep 2018

Patients admitted to the intensive care unit (ICU) with severe influenza have an elevated risk of developing invasive pulmonary aspergillosis, particularly if they are immunocompromised at time of admission, a recent study has shown.

Radha Chitale, 06 Apr 2016
An investigational device monitoring fluid accumulation in the lungs significantly reduced hospitalization due to heart failure and death by any cause among heart failure patients compared with standard monitoring and treatment methods, according to results from the IMPEDANCE-HF trial reported during the recent ACC meeting in Chicago, Illinois, US.