Most Read Articles
16 Jan 2017
There are various ear, nose, and throat (ENT) conditions which present to the GP’s clinic. Dr Jason Hwang, an ENT Consultant from the Department of Otolaryngology at Gleneagles Hospital in Singapore, speaks on how the majority of the conditions can be effectively managed at the primary care level seeing that these can be treated medically without the need for surgical intervention.
16 Dec 2016
Two of the most common hospital-acquired, ventilator-associated nonfermentative gram-negative pneumonia pathogens—Acinetobacter baumannii and Pseudomonas aeruginosa—develop significant resistance to most therapeutic options available, and they should be managed with combination therapies until new antimicrobial agents are developed, according to a study.
24 May 2018
In children and adolescents with cystic fibrosis (CF), synbiotic supplementation appears to be effective at reducing proinflammatory markers such as interleukin (IL)-6 and -8, and nitric oxide metabolites (NOx), a recent study has found.
15 Apr 2018
The use of transbronchial lung biopsy (TBLB) appears to be safe and effective for the pathological diagnosis of lymphangioleiomyomatosis (LAM), suggests a recent study.

High-dose rifampin may help shorten tuberculosis treatment

08 Jul 2018
There were approximately 36 cases of TB per 100,000 population in Singapore last year

Higher doses of rifampin result in more rapid sputum sterilization and similar toxicity, a study has shown. These findings support the investigation of increased rifampin doses to shorten tuberculosis treatment.

To determine whether increased rifampin doses could shorten standard therapy for tuberculosis without increased toxicity, the investigators conducted a blinded, randomized, controlled phase II clinical trial involving 180 adults with new smear-positive pulmonary tuberculosis, susceptible to isoniazid and rifampin. Participants were randomized 1:1:1 to 10, 15 and 20 mg/kg/day of rifampin during the intensive phase.

The primary efficacy and safety endpoints were as follows: change in elimination rate of M. tuberculosis log10 colony forming units and frequency of grade 2 rifampin related adverse events (AEs). Efficacy by treatment arm and by primary (AUC/MIC) and secondary (AUC) pharmacokinetic exposure was also reported.

Differences of –0.011 (95 percent CI, –0.025 to 0.002; p=0.230) and –0.022 (–0.046 to –0.002; p=0.022) log10 colony forming units/mL/day were recorded in the modified intention-to-treat and per-protocol analyses, respectively, for every 5 mg/kg/day increase in rifampin dose. In the per-protocol group, elimination rate significantly increased with rifampin AUC0-6 (p=0.011) but not with AUC0-6/MIC99.9 (p=0.053).

Occurrence of grade 2 rifampin-related AEs showed similar frequency across the three treatment arms: 26 (43.3 percent), 31 (51.7 percent) and 23 (38.3 percent) participants in the 10, 15 and 20 mg/kg/day rifampin dose groups, respectively, had at least one AE (p=0.7092) up to 4 weeks after the intensive phase. In addition, 11 (6.1 percent) participants had treatment failure or disease recurrence.

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Most Read Articles
16 Jan 2017
There are various ear, nose, and throat (ENT) conditions which present to the GP’s clinic. Dr Jason Hwang, an ENT Consultant from the Department of Otolaryngology at Gleneagles Hospital in Singapore, speaks on how the majority of the conditions can be effectively managed at the primary care level seeing that these can be treated medically without the need for surgical intervention.
16 Dec 2016
Two of the most common hospital-acquired, ventilator-associated nonfermentative gram-negative pneumonia pathogens—Acinetobacter baumannii and Pseudomonas aeruginosa—develop significant resistance to most therapeutic options available, and they should be managed with combination therapies until new antimicrobial agents are developed, according to a study.
24 May 2018
In children and adolescents with cystic fibrosis (CF), synbiotic supplementation appears to be effective at reducing proinflammatory markers such as interleukin (IL)-6 and -8, and nitric oxide metabolites (NOx), a recent study has found.
15 Apr 2018
The use of transbronchial lung biopsy (TBLB) appears to be safe and effective for the pathological diagnosis of lymphangioleiomyomatosis (LAM), suggests a recent study.