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18 Apr 2018
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High dietary inflammatory index tied to increased cancer risk

11 Apr 2018
Global phenomenon: Bad diet is one of the causes of early death.

A significant association exists between higher dietary inflammatory index (DII) and risk of cancer, according to the results of a recent dose-response meta-analysis.

A total of 44 high-quality studies (n=1,082,092 participants) were included. An elevated DII (continuous–relative risk [RR], 1.13; 95 percent CI, 1.09–1.16; category DIIhighest vs lowest–RR, 1.58; 1.45–1.72) was independently associated with higher cancer risk, except for lung cancer and Australian studies.

There was a linear dose-response relation between DII and overall risk of cancer, with an 8.3-percent increase in cancer risk per DII score. The pooled RR of DII and cancer risk was 1.86 (1.63–2.13) from 30 case-control studies and 1.29 (1.19–1.40) from 14 prospective cohorts.

These findings were supported by both sensitivity analysis and Egger’s test.

The investigators conducted a dose-response meta-analysis to examine the association between DII and cancer incidence. PubMed, Embase, Web of Science and the Cochrane library were systematically searched up to 5 November 2017.

After extracting data, the investigators calculated pooled RRs and performed dose-response analyses using a restricted cubic spline model with 4 knots. They also performed subgroup analyses, sensitivity analyses and tests for publication bias.

“More prospective studies with large sample sizes, involving more ethnic groups and different cancer types, are required in the future,” the investigators said.

“A newly developed DII to evaluate the inflammatory potential of diets was published recently. Many studies have investigated the link between diet-related inflammation and human cancer risk, but the results remain controversial,” they noted.

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Most Read Articles
18 Apr 2018
Higher intake levels of coffee appear to be associated with reduced risk of developing chronic kidney disease, according to data from the Atherosclerosis Risk in Communities Study.
Jairia Dela Cruz, 6 days ago
Infants delivered via caesarean section may be at increased risk of developing acute lymphoblastic leukaemia, according to a US study. Altered microbiota colonization is a possible explanation for this risk, although clear biological mechanisms have yet to be established.
5 days ago
Treatment with danegaptide does not improve myocardial salvage in patients with ST-segment elevation myocardial infarction (STEMI) undergoing primary percutaneous coronary intervention, according to the results of a phase II study.
Pearl Toh, 3 days ago
Tai Chi may be equivalent to pulmonary rehabilitation (PR) in improving health status of patients with chronic obstructive pulmonary disease (COPD), a recent study shows.