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High dietary inflammatory index tied to increased cancer risk

11 Apr 2018
Global phenomenon: Bad diet is one of the causes of early death.

A significant association exists between higher dietary inflammatory index (DII) and risk of cancer, according to the results of a recent dose-response meta-analysis.

A total of 44 high-quality studies (n=1,082,092 participants) were included. An elevated DII (continuous–relative risk [RR], 1.13; 95 percent CI, 1.09–1.16; category DIIhighest vs lowest–RR, 1.58; 1.45–1.72) was independently associated with higher cancer risk, except for lung cancer and Australian studies.

There was a linear dose-response relation between DII and overall risk of cancer, with an 8.3-percent increase in cancer risk per DII score. The pooled RR of DII and cancer risk was 1.86 (1.63–2.13) from 30 case-control studies and 1.29 (1.19–1.40) from 14 prospective cohorts.

These findings were supported by both sensitivity analysis and Egger’s test.

The investigators conducted a dose-response meta-analysis to examine the association between DII and cancer incidence. PubMed, Embase, Web of Science and the Cochrane library were systematically searched up to 5 November 2017.

After extracting data, the investigators calculated pooled RRs and performed dose-response analyses using a restricted cubic spline model with 4 knots. They also performed subgroup analyses, sensitivity analyses and tests for publication bias.

“More prospective studies with large sample sizes, involving more ethnic groups and different cancer types, are required in the future,” the investigators said.

“A newly developed DII to evaluate the inflammatory potential of diets was published recently. Many studies have investigated the link between diet-related inflammation and human cancer risk, but the results remain controversial,” they noted.

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Most Read Articles
3 days ago
Prenatal and postpartum vitamin D supplementation does not appear to improve foetal or infant growth, a study reports.
5 days ago
Excessive daytime sleepiness appears to increase the long-term risk of amyloid β (Aβ) deposition, a recent study has shown.
5 days ago
Substituting diets high in carbohydrates with those high in monounsaturated fatty acids in the context of low saturated fatty acids do not appear to yield favourable effects on blood pressure, according to a meta-analysis.
6 days ago
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