Most Read Articles
22 Jul 2020
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Elvira Manzano, 28 Jul 2020
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High CRP values, low albumin levels predict mortality in ED patients

18 Jun 2020

High nutritional risk and elevated C-reactive protein (CRP) values independently correlate with hypoalbuminaemia, while both parameters and low serum albumin levels separately predict mortality, according to a study.

The authors prospectively enrolled adult patients in the medical emergency department (ED) of a Swiss tertiary care centre. Multivariate regression analyses were performed to examine the relationships of CRP and Nutritional Risk Screening 2002 as markers of inflammation and poor nutritional status, respectively, with low serum albumin levels and mortality.

A total of 2,465 patients were included, of whom 1,019 (41 percent) had low serum albumin levels (<34 g/L), 619 (25.1 percent) had increased nutritional risk (Nutritional Risk Screening 2002 ≥3), and 1,086 (44.1 percent) had CRP values >20 mg/L.

In multivariate analyses adjusted for age, gender, diagnosis, and comorbidities, results showed that elevated CRP values (adjusted odds ratio [aOR], 10.51, 95 percent confidence interval [CI], 7.51–14.72; p<0.001) and increased malnutrition risk (aOR, 2.87, 95 percent CI, 1.98–4.15; p<0.001) were associated with low serum albumin levels, even adjusting for both parameters.

Elevated CRP values, increased nutritional risk, and low serum albumin levels each predicted 30-day mortality, with areas under the curve of 0.77, 0.70, and 0.75, respectively. Combination of all parameters demonstrated an area under the curve of 0.82 to predict mortality.

“Combining [these parameters] during initial evaluation of patients in EDs facilitates mortality risk stratification,” the authors said.

“Low serum albumin levels resulting from inflammation-induced capillary leakage or disease-related anorexia during acute illness are associated with poor outcomes,” they noted.

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Most Read Articles
22 Jul 2020
A picosecond alexandrite laser (PSAL) appears to be superior to Q-switched alexandrite laser (QSAL) for the treatment of nevus of Ota, as shown by its better clinical results and fewer adverse events, according to a study.
Elvira Manzano, 28 Jul 2020
The efficacy and cardiovascular (CV) safety of the SGLT2* inhibitor empagliflozin vs DPP-4** inhibitors and GLP-1*** receptor agonists in real-world patients were demonstrated in two interim analyses of the EMPRISE+ study presented at ADA 2020.
3 days ago
Supplementation with probiotics may have positive effects in patients with type 2 diabetes mellitus (T2DM), reports a recent meta-analysis.
Stephen Padilla, 28 Jul 2020
Higher levels of plasma vitamin C, total and individual carotenoid biomarkers, and their composite biomarker score appear to reduce the incidence of type 2 diabetes (T2D), according to the results of a prospective case-cohort study in eight European countries.