Most Read Articles
Elaine Soliven, 3 days ago

Switching from efavirenz/emtricitabine/tenofovir disoproxil fumarate (EFV/FTC/TDF) to the new bictegravir/ emtricitabine/tenofovir alafenamide (BIC/FTC/TAF) regimen maintained high rates of virological suppression in adults who are living with HIV*, according to a study presented at AIDS 2020.

01 Aug 2020
Supplementation with probiotics may have positive effects in patients with type 2 diabetes mellitus (T2DM), reports a recent meta-analysis.
Stephen Padilla, 4 days ago
Pre-exposure prophylaxis (PrEP) containing either long-acting injectable cabotegravir (CAB) or tenofovir/emtricitabine (TDF/FTC) is safe and effective for transgender women (TGW) and cisgender men who have sex with men (MSM), but CAB results in a much lower HIV incidence compared to TDF/FTC, results of the HIV Prevention Trials Network (HPTN) 083 have shown.
Jairia Dela Cruz, 3 days ago
Monthly prophylaxis with the fixed-dose combination of naphthoquine-azithromycin (NQAZ) is well tolerated and confers significant protection against infection with Plasmodium parasites among individuals residing in malaria-endemic areas in Southeast Asia, as shown in the results of a phase III trial.

High CRP values, low albumin levels predict mortality in ED patients

18 Jun 2020

High nutritional risk and elevated C-reactive protein (CRP) values independently correlate with hypoalbuminaemia, while both parameters and low serum albumin levels separately predict mortality, according to a study.

The authors prospectively enrolled adult patients in the medical emergency department (ED) of a Swiss tertiary care centre. Multivariate regression analyses were performed to examine the relationships of CRP and Nutritional Risk Screening 2002 as markers of inflammation and poor nutritional status, respectively, with low serum albumin levels and mortality.

A total of 2,465 patients were included, of whom 1,019 (41 percent) had low serum albumin levels (<34 g/L), 619 (25.1 percent) had increased nutritional risk (Nutritional Risk Screening 2002 ≥3), and 1,086 (44.1 percent) had CRP values >20 mg/L.

In multivariate analyses adjusted for age, gender, diagnosis, and comorbidities, results showed that elevated CRP values (adjusted odds ratio [aOR], 10.51, 95 percent confidence interval [CI], 7.51–14.72; p<0.001) and increased malnutrition risk (aOR, 2.87, 95 percent CI, 1.98–4.15; p<0.001) were associated with low serum albumin levels, even adjusting for both parameters.

Elevated CRP values, increased nutritional risk, and low serum albumin levels each predicted 30-day mortality, with areas under the curve of 0.77, 0.70, and 0.75, respectively. Combination of all parameters demonstrated an area under the curve of 0.82 to predict mortality.

“Combining [these parameters] during initial evaluation of patients in EDs facilitates mortality risk stratification,” the authors said.

“Low serum albumin levels resulting from inflammation-induced capillary leakage or disease-related anorexia during acute illness are associated with poor outcomes,” they noted.

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Most Read Articles
Elaine Soliven, 3 days ago

Switching from efavirenz/emtricitabine/tenofovir disoproxil fumarate (EFV/FTC/TDF) to the new bictegravir/ emtricitabine/tenofovir alafenamide (BIC/FTC/TAF) regimen maintained high rates of virological suppression in adults who are living with HIV*, according to a study presented at AIDS 2020.

01 Aug 2020
Supplementation with probiotics may have positive effects in patients with type 2 diabetes mellitus (T2DM), reports a recent meta-analysis.
Stephen Padilla, 4 days ago
Pre-exposure prophylaxis (PrEP) containing either long-acting injectable cabotegravir (CAB) or tenofovir/emtricitabine (TDF/FTC) is safe and effective for transgender women (TGW) and cisgender men who have sex with men (MSM), but CAB results in a much lower HIV incidence compared to TDF/FTC, results of the HIV Prevention Trials Network (HPTN) 083 have shown.
Jairia Dela Cruz, 3 days ago
Monthly prophylaxis with the fixed-dose combination of naphthoquine-azithromycin (NQAZ) is well tolerated and confers significant protection against infection with Plasmodium parasites among individuals residing in malaria-endemic areas in Southeast Asia, as shown in the results of a phase III trial.