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01 Nov 2019
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High coronary artery calcium tied to MACE in patients with suspected coronary artery disease

21 Dec 2019
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An elevated coronary artery calcium (CAC) level is a strong predictor of major adverse cardiac events (MACE) in stable, symptomatic patients with suspected coronary artery disease (CAD), reports a recent meta-analysis.

Accessing the databases of Google Scholar, Cochrane CENTRAL, Web of Science, Ovid Medline and Embase, researchers identified 19 reports corresponding to 34,041 participants. There were 1,601 cardiovascular events analysed, of which 1.18 percent (n=158) occurred in patients with a CAC score of 0.

The risk of MACE was significantly elevated in patients with any detectable CAC (relative risk ratio, 5.71, 95 percent confidence interval [CI], 3.98–8.19). The same was true for the occurrence of either all-cause mortality or nonfatal myocardial infarction, according to a meta-analysis of 13 studies (relative risk ratio, 3.64, 95 percent CI, 2.68–4.96).

Disaggregating according to different CAC score thresholds, researchers found that relative to patients with score 0, those with scores >100 (relative risk ratio, 9.57, 95 percent CI, 6.87–13.33) or >400 (relative risk ratio, 8.30, 95 percent CI, 4.95–13.90) were significantly more likely to develop MACEs.

In a sensitivity analysis of 12 studies where all participants were reported to be symptomatic (n=20,421), researchers also found an elevated risk of MACE (relative risk ratio, 5.85, 95 percent CI, 3.69–9.27).

“The findings are clinically relevant for the large group of symptomatic patients and, although a multicentre randomized trial will be needed to assess the exact utility and incremental predictive value of calcium testing, our analyses indicate that CAC scanning should be helpful in clinical decision making in a considerable number of stable patients with chest pain,” said the researchers.

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Most Read Articles
01 Nov 2019
Women with hypertensive disorders of pregnancy, especially pre-eclampsia, are at heightened risk of developing cardiovascular disorder and chronic hypertension, with the risk becoming apparent soon after pregnancy, a study has found.
Roshini Claire Anthony, 29 May 2019

Gestational diabetes and abnormal glucose levels in pregnancy, as determined with an oral glucose challenge test (OGCT) at 24–28 weeks gestation, could signal a future risk of cardiovascular disease (CVD)*, according to a recent study.

07 Jul 2019
Plasma creatinine kinase activity, measure during early pregnancy, influences blood pressure during pregnancy and contributes to severe gestational hypertension diagnosed before 34 weeks of gestation, according to a recent study. There is no association between creatinine kinase and other hypertensive disorders during pregnancy.
Pank Jit Sin, 16 Oct 2019
While a diagnosis of cancer is often met with concern and devastation, the same is barely true for heart failure. However, the mortality rate for those suffering from heart failure is worse than some common cancers, such as prostate and breast cancers.