Most Read Articles
Tristan Manalac, 12 Aug 2018
The risk of complicated appendicitis is lower in children with IgE-mediated allergy, according to a recent study.
17 Aug 2018
Ciprofloxacin once-weekly delivers the same efficacy as daily norfloxacin for preventing spontaneous bacterial peritonitis (SBP) in cirrhotic patients with ascites, a recent study has shown.
Jairia Dela Cruz, 10 Aug 2018
Noninclusion of antibiotics in the management of uncomplicated acute diverticulitis is feasible and fairly safe, with long-term follow-up data from the DIABOLO study showing that such a strategy does not result in increased incidence of complicated or recurrent diverticulitis or sigmoid resections over 2 years.
Elvira Manzano, 16 Feb 2016
Postoperative delirium (POD) may be a common occurrence in older patients following gastrointestinal (GI) surgery, according to a systematic review and meta-analysis, highlighting the need for physicians to identify patients at risk and come up with tailored interventions for POD.

High childhood BMI raises risk for Crohn’s disease in adulthood

07 Jun 2018

Higher body mass index (BMI) in childhood appears to be significantly associated with Crohn’s disease (CD) before 30 years of age, a recent study has shown.

Over 10 million person-years of follow-up, CD was diagnosed in 1,500 individuals, of whom 634 were male and 866 were female. Incidence rate by age showed two peaks: one at 20–30 years (2.2 cases per 10,000 person-years) and the other at 65–75 years (2.9 cases per 10,000 person-years).

Using BMI z-scores from 7–13 years of age, researchers showed that each unit increase was associated with a significant increase in the risk of being diagnosed with CD before the age of 30 years. The same effect was absent for CD diagnosis after 30 years of age.

On the other hand, ulcerative colitis (UC) had a significant but inverse correlation with BMI z-scores from ages 7–13 years. UC was diagnosed in 2,732 participants and similarly showed two incidence peaks according to age: at 20–30 years (2.8 cases per 10,000 person-years) and at 65–75 years (6.0 cases per 10,000 person-years).

Subsequent analysis stratified according to BMI categories showed that the risk was most apparent for obese children and only at specific ages. For instance, only obese children at age 11 (hazard ratio [HR], 1.31; 95 percent CI, 1.04–1.66; p=0.02), 12 (HR, 1.40; 1.12–1.77; p=0.01) and 13 (HR, 1.40; 1.12–1.76; p=0.002) years were at significantly elevated risks of CD development relative to normal weight children. The interaction with age of CD diagnosis was attenuated in this analysis.

Linking the Danish National Patient Register with the Copenhagen School Health Records Register, researchers identified 316,799 children, of whom 4,232 were diagnosed with inflammatory bowel diseases (IBD). Cox regression analysis was used to determine the relationship between childhood BMI with IBD risk.

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Most Read Articles
Tristan Manalac, 12 Aug 2018
The risk of complicated appendicitis is lower in children with IgE-mediated allergy, according to a recent study.
17 Aug 2018
Ciprofloxacin once-weekly delivers the same efficacy as daily norfloxacin for preventing spontaneous bacterial peritonitis (SBP) in cirrhotic patients with ascites, a recent study has shown.
Jairia Dela Cruz, 10 Aug 2018
Noninclusion of antibiotics in the management of uncomplicated acute diverticulitis is feasible and fairly safe, with long-term follow-up data from the DIABOLO study showing that such a strategy does not result in increased incidence of complicated or recurrent diverticulitis or sigmoid resections over 2 years.
Elvira Manzano, 16 Feb 2016
Postoperative delirium (POD) may be a common occurrence in older patients following gastrointestinal (GI) surgery, according to a systematic review and meta-analysis, highlighting the need for physicians to identify patients at risk and come up with tailored interventions for POD.