Most Read Articles
17 Dec 2018
Modifiable lifestyle behaviours, such as diet and exercise, significantly affect the risk of colorectal cancer (CRC), a recent study has shown.
Roshini Claire Anthony, 21 Apr 2016
Twenty-year survival is possible in almost 80 percent of children who had a liver transplant and were given cyclosporine as their primary immunosuppressive regimen, according to a study presented at the annual meeting of the European Association for the Study of the Liver (EASL) International Liver Congress™ (ILC) 2016 in Barcelona, Spain.
Pearl Toh, 10 Jan 2019
Adding a proton-pump inhibitor (PPI) to anticoagulant therapy significantly lowers the risk of hospitalizations for upper gastrointestinal (GI) tract bleeding associated with anticoagulant use, a study finds.
6 days ago
Among patients with inflammatory bowel disease (IBD), older age at the time of IBD diagnosis and longer disease duration are associated with a heightened risk of developing colitis-associated neoplasia, a study has found.

High childhood BMI raises risk for Crohn’s disease in adulthood

07 Jun 2018

Higher body mass index (BMI) in childhood appears to be significantly associated with Crohn’s disease (CD) before 30 years of age, a recent study has shown.

Over 10 million person-years of follow-up, CD was diagnosed in 1,500 individuals, of whom 634 were male and 866 were female. Incidence rate by age showed two peaks: one at 20–30 years (2.2 cases per 10,000 person-years) and the other at 65–75 years (2.9 cases per 10,000 person-years).

Using BMI z-scores from 7–13 years of age, researchers showed that each unit increase was associated with a significant increase in the risk of being diagnosed with CD before the age of 30 years. The same effect was absent for CD diagnosis after 30 years of age.

On the other hand, ulcerative colitis (UC) had a significant but inverse correlation with BMI z-scores from ages 7–13 years. UC was diagnosed in 2,732 participants and similarly showed two incidence peaks according to age: at 20–30 years (2.8 cases per 10,000 person-years) and at 65–75 years (6.0 cases per 10,000 person-years).

Subsequent analysis stratified according to BMI categories showed that the risk was most apparent for obese children and only at specific ages. For instance, only obese children at age 11 (hazard ratio [HR], 1.31; 95 percent CI, 1.04–1.66; p=0.02), 12 (HR, 1.40; 1.12–1.77; p=0.01) and 13 (HR, 1.40; 1.12–1.76; p=0.002) years were at significantly elevated risks of CD development relative to normal weight children. The interaction with age of CD diagnosis was attenuated in this analysis.

Linking the Danish National Patient Register with the Copenhagen School Health Records Register, researchers identified 316,799 children, of whom 4,232 were diagnosed with inflammatory bowel diseases (IBD). Cox regression analysis was used to determine the relationship between childhood BMI with IBD risk.

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Most Read Articles
17 Dec 2018
Modifiable lifestyle behaviours, such as diet and exercise, significantly affect the risk of colorectal cancer (CRC), a recent study has shown.
Roshini Claire Anthony, 21 Apr 2016
Twenty-year survival is possible in almost 80 percent of children who had a liver transplant and were given cyclosporine as their primary immunosuppressive regimen, according to a study presented at the annual meeting of the European Association for the Study of the Liver (EASL) International Liver Congress™ (ILC) 2016 in Barcelona, Spain.
Pearl Toh, 10 Jan 2019
Adding a proton-pump inhibitor (PPI) to anticoagulant therapy significantly lowers the risk of hospitalizations for upper gastrointestinal (GI) tract bleeding associated with anticoagulant use, a study finds.
6 days ago
Among patients with inflammatory bowel disease (IBD), older age at the time of IBD diagnosis and longer disease duration are associated with a heightened risk of developing colitis-associated neoplasia, a study has found.