Most Read Articles
11 May 2020
This second issue revisits the impact EMPA-REG OUTCOME had on clinical practice and helps readers discover how it gives life back to patients through its cardiovascular indication. Learn how it was approved and the possible mechanisms for its cardiovascular benefits.
Stephen Padilla, 22 Jul 2019
Zinc supplementation significantly lowers key glycaemic indicators, particularly fasting glucose (FG) in individuals with diabetes and in those who received an inorganic supplement, results of a systematic review and meta-analysis have shown.
Elaine Soliven, 15 Oct 2020

Higher levels of exercise appear to be associated with a lower risk of all-cause mortality in adults with type 2 diabetes (T2D) compared with no exercise at all, according to a study presented at EASD 2020.

Roshini Claire Anthony, 11 Jun 2020

By reducing hepatic enzyme levels and improving markers of hepatic steatosis or fibrosis, bariatric surgery may help reduce the risk of non-alcoholic fatty liver disease (NAFLD), according to a study from Portugal presented at ENDO 2020.

High blood sugar, triglycerides after meal may signal mortality risk in T2D

28 Sep 2020

In patients with type 2 diabetes (T2D), postprandial hyperglycaemia and hypertriglyceridemia worsens survival outlook, finds a new study.

The study included 1,928 T2D patients with ≥1 year of follow-up information. Two-hour post-breakfast blood glucose (2h-BG) was measured in 1,122 patients, and postprandial serum triglyceride (ppTG) was quantified in 1,826. The primary endpoint was all-cause mortality, but the researchers also sought to determine threshold values for the assessment of death risk.

Over 17,429 person-years of follow-up in the BG cohort, 162 deaths were reported. In comparison, the TG cohort was followed for 28,026 person-years, during which 253 deaths occurred. The resulting crude incidence rates were 9.29 and 9.03 events per 1,000 person-years, respectively.

Multivariate Cox regression analysis showed that across quintiles of 2h-BG and ppTG, all-cause mortality risk varied significantly. That is, the top vs bottom quintile of 2h-BG (hazard ratio [HR], 2.37, 95 percent confidence interval [CI], 1.26–4.47; ptrend=0.034) and ppTG (HR, 1.63, 95 percent CI, 1.03–2.60; ptrend=0.007), the risk of all-cause mortality was significantly higher.

Even when taking both blood markers as continuous variables, the researchers saw the link to death risk. Each standard deviation increase in 2h-BG (HR, 1.34, 95 percent CI, 1.08–1.67) and ppTG (HR, 1.24, 95 percent CI, 1.06–1.45) led to a significant spike in all-cause mortality risk. These interactions remained significant even when controlling for medications.

Kaplan-Meier curves identified threshold 2h-BG and ppTG threshold values of 13.8 and 2.30 mmol/L, respectively. Patients who fell beyond these cut-offs showed increasingly greater all-cause mortality risk after 2 and 5 years of follow-up, respectively.

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Most Read Articles
11 May 2020
This second issue revisits the impact EMPA-REG OUTCOME had on clinical practice and helps readers discover how it gives life back to patients through its cardiovascular indication. Learn how it was approved and the possible mechanisms for its cardiovascular benefits.
Stephen Padilla, 22 Jul 2019
Zinc supplementation significantly lowers key glycaemic indicators, particularly fasting glucose (FG) in individuals with diabetes and in those who received an inorganic supplement, results of a systematic review and meta-analysis have shown.
Elaine Soliven, 15 Oct 2020

Higher levels of exercise appear to be associated with a lower risk of all-cause mortality in adults with type 2 diabetes (T2D) compared with no exercise at all, according to a study presented at EASD 2020.

Roshini Claire Anthony, 11 Jun 2020

By reducing hepatic enzyme levels and improving markers of hepatic steatosis or fibrosis, bariatric surgery may help reduce the risk of non-alcoholic fatty liver disease (NAFLD), according to a study from Portugal presented at ENDO 2020.