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Roshini Claire Anthony, 4 days ago

The combined use of piperacillin and tazobactam does not appear to be a suitable alternative to meropenem for patients with bloodstream infections caused by ceftriaxone-resistant Escherichia coli (E. coli) or Klebsiella pneumoniae (K. pneumoniae), according to results of the MERINO* trial.

Tristan Manalac, 19 May 2018
Taking oral antibiotics appears to increase the risk of nephrolithiasis, according to a recent study. Moreover, the risk seems to be compounded for individuals with recent antibiotic exposure and those who were exposed at a younger age.
2 days ago
Patients with inflammatory bowel disease are at increased risk of developing acute myocardial infarction (AMI) or heart failure, although the prevalence of traditional risk factors for such cardiovascular disorders appears to be low, as reported in a recent study.
3 days ago
Early renin-angiotensin-aldosterone system (RAAS) blockade with renin-angiotensin system inhibitors (RASI) leads to better short- and long-term renal outcomes in systemic lupus erythematosus (SLE) patients with antiphospholipid-associated nephropathy (aPLN), according to a study, adding that this renal protective effect is independent of RASI’s antihypertensive and antiproteinuric effects.

High anti-CCP titre linked to severe carotid plaque in rheumatoid arthritis

20 Jul 2017

Patients with rheumatoid arthritis (RA) appear to have a high prevalence of any carotid plaques and severe carotid plaques, with high titre of anticyclic citrullinated peptide (anti-CCP) antibodies a risk factor for severe carotid atherosclerotic plaque in RA.

The study included 200 patients with RA and 202 matched healthy controls. Researchers analysed the carotid ultrasound, clinical data and cardiovascular risk factors for each individual. Atherosclerotic plaque was defined as an intima-media thickness of ≥1.1 mm. The severity of plaque was evaluated by the plaque score, which was calculated as the sum of the maximal thickness of all plaques in bilateral carotid arteries.

Carotid plaque was found to be more common in the RA group vs the control group (47.0 vs 36.1 percent; p=0.027), with plaque score being significantly higher among RA patients (p=0.032).

On logistic regression analysis, RA emerged as an independent risk factor for the presence of plaque (adjusted odds ratio, 1.68; 95 percent CI, 1.03 to 2.74). Compared with RA patients without plaque, those with plaque had significantly higher anti-CCP antibodies titre (315.8 vs 281.1 U/mL; p=0.005).

A multiple linear regression analysis demonstrated an association between anti-CCP antibody titre and plaque score among patients with RA.

The leading cause of mortality in RA is cardiovascular death, attributed to approximately half of the total deaths. Excess CV risk in this population may be explained by traditional risk factors such as hypertension, type 2 diabetes, smoking, hypercholesterolemia, obesity and physical inactivity. Carotid artery plaque, as identified using ultrasound, indicates very high CV risk and is reported to strongly predict incident cardiovascular event rates in both RA patients and non-RA controls. [Open Rheumatol J 2016;10:49–59; Arthritis Res Ther 2015;17:55]

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Most Read Articles
Roshini Claire Anthony, 4 days ago

The combined use of piperacillin and tazobactam does not appear to be a suitable alternative to meropenem for patients with bloodstream infections caused by ceftriaxone-resistant Escherichia coli (E. coli) or Klebsiella pneumoniae (K. pneumoniae), according to results of the MERINO* trial.

Tristan Manalac, 19 May 2018
Taking oral antibiotics appears to increase the risk of nephrolithiasis, according to a recent study. Moreover, the risk seems to be compounded for individuals with recent antibiotic exposure and those who were exposed at a younger age.
2 days ago
Patients with inflammatory bowel disease are at increased risk of developing acute myocardial infarction (AMI) or heart failure, although the prevalence of traditional risk factors for such cardiovascular disorders appears to be low, as reported in a recent study.
3 days ago
Early renin-angiotensin-aldosterone system (RAAS) blockade with renin-angiotensin system inhibitors (RASI) leads to better short- and long-term renal outcomes in systemic lupus erythematosus (SLE) patients with antiphospholipid-associated nephropathy (aPLN), according to a study, adding that this renal protective effect is independent of RASI’s antihypertensive and antiproteinuric effects.