Most Read Articles
Elaine Soliven, 4 days ago

Switching from efavirenz/emtricitabine/tenofovir disoproxil fumarate (EFV/FTC/TDF) to the new bictegravir/ emtricitabine/tenofovir alafenamide (BIC/FTC/TAF) regimen maintained high rates of virological suppression in adults who are living with HIV*, according to a study presented at AIDS 2020.

01 Aug 2020
Supplementation with probiotics may have positive effects in patients with type 2 diabetes mellitus (T2DM), reports a recent meta-analysis.
Stephen Padilla, 4 days ago
Pre-exposure prophylaxis (PrEP) containing either long-acting injectable cabotegravir (CAB) or tenofovir/emtricitabine (TDF/FTC) is safe and effective for transgender women (TGW) and cisgender men who have sex with men (MSM), but CAB results in a much lower HIV incidence compared to TDF/FTC, results of the HIV Prevention Trials Network (HPTN) 083 have shown.
Jairia Dela Cruz, 3 days ago
Monthly prophylaxis with the fixed-dose combination of naphthoquine-azithromycin (NQAZ) is well tolerated and confers significant protection against infection with Plasmodium parasites among individuals residing in malaria-endemic areas in Southeast Asia, as shown in the results of a phase III trial.

High adherence to 5-alpha reductase inhibitor therapy lowers risk of surgery for BPH

31 Jul 2020

Treatment with 5-alpha reductase inhibitor is associated with a reduced risk of surgical intervention in men with benign prostatic hyperplasia (BPH), a recent study has shown. Patients also show high medication adherence outside of clinical trials.

In addition, 5-alpha reductase inhibitor therapy exhibits a modest clinical benefit and appears to be more feasible for older men with BPH than previously reported.

Medication adherence among 3,107 men initiating 5-alpha reductase inhibitor therapy for BPH and filling at least two prescriptions was high (74.9 percent) during the first year. Those with low adherence had 29-percent higher risks of undergoing surgical intervention (95 percent confidence interval [CI], 1.02–1.59; p=0.036) after adjusting for age, BPH severity, presence of haematuria, bladder stones, and type of 5-alpha reductase inhibitors.

Other risk factors for surgical intervention included the presence of bladder stones (hazard ratio [HR], 1.70, 95 percent CI, 1.02–2.86; p=0.04) and use of finasteride vs dutasteride (HR, 1.41, 95 percent CI, 1.01–1.98; p=0.05).

In this study, the investigators identified men initiating a 5-alpha reductase inhibitor for benign prostatic hyperplasia with more than one medication dispensation using healthcare and pharmacy claims from Partners Healthcare Medicare Accountable Care Organization enrolees (January 2009 to July 2018).

Adherence was defined as proportion of days covered of 80 percent. The investigators used Cox proportional hazards model to examine the primary outcome of treatment failure, defined as any BPH-related surgery.

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Most Read Articles
Elaine Soliven, 4 days ago

Switching from efavirenz/emtricitabine/tenofovir disoproxil fumarate (EFV/FTC/TDF) to the new bictegravir/ emtricitabine/tenofovir alafenamide (BIC/FTC/TAF) regimen maintained high rates of virological suppression in adults who are living with HIV*, according to a study presented at AIDS 2020.

01 Aug 2020
Supplementation with probiotics may have positive effects in patients with type 2 diabetes mellitus (T2DM), reports a recent meta-analysis.
Stephen Padilla, 4 days ago
Pre-exposure prophylaxis (PrEP) containing either long-acting injectable cabotegravir (CAB) or tenofovir/emtricitabine (TDF/FTC) is safe and effective for transgender women (TGW) and cisgender men who have sex with men (MSM), but CAB results in a much lower HIV incidence compared to TDF/FTC, results of the HIV Prevention Trials Network (HPTN) 083 have shown.
Jairia Dela Cruz, 3 days ago
Monthly prophylaxis with the fixed-dose combination of naphthoquine-azithromycin (NQAZ) is well tolerated and confers significant protection against infection with Plasmodium parasites among individuals residing in malaria-endemic areas in Southeast Asia, as shown in the results of a phase III trial.