Most Read Articles
18 May 2020
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Glucagon-like peptide-1 receptor agonists (GLP-1RA) are more effective than basal insulin in the management of total (TC) and low-density lipoprotein cholesterol (LDL-C), reveals a recent study.
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Increased coffee consumption among regular drinkers is associated with higher estimated glomerular filtration rate and confers protection against the risk of chronic kidney disease stages G3–G5 and albuminuria, as shown in a study.
Jairia Dela Cruz, 16 May 2020
Excess weight, greater abdominal fat, inflammation and low physical performance can all contribute to insulin resistance in middle-age Singaporean women, and these variables explain why the condition is more common among women of Chinese than Malay and Indian ethnicities, a study has found.

High 1-hour glucose load impairs insulin secretion in men

20 Mar 2020
Healthcare providers should provide appropriate advice on the appropriate adjustments for diabetic patients during the fasting month of Ramadan.

Insulin secretion is reduced in people with elevated 1-hour glucose levels during oral glucose tolerance tests (OGTTs), a new Japan study has shown.

Researchers enrolled 59 nonobese Japanese men aged 30–50 years with normal glucose tolerance. After OGTT, 29 participants had 1-hour glucose levels <155 mg/dL, while 30 had concentrations at or above the threshold value. A two-step hyperinsulinaemic-euglycaemic clamp test was performed to assess insulin sensitivity in muscle, liver and adipose tissues.

Baseline characteristics were largely comparable between the low- and high-glucose subgroups, though high-molecular-weight (HMW) adiponectin appeared to be lower in those with high 1-hour glucose concentrations. Insulin sensitivity in muscle, liver and adipose tissues were likewise similar between subgroups.

Single correlation analyses revealed that glucose at 60 minutes was significantly but inversely correlated with insulinogenic index (r, –0.38; p=0.003) and HMW adiponectin (r, –0.38; p=0.003).

This was further confirmed through multiple regression analysis, which found an independent and significant link between 1-hour glucose concentrations with insulinogenic index (β, –0.452; p=0.001) and HMW adiponectin (β, –0.329; p=0.012). In comparison, age, body mass index and muscle insulin sensitivity were all unrelated.

“[S]tudy participants with elevated 1-hour glucose levels during OGTT had a reduced early insulin secretion than participants with low 1-hour glucose levels,” the researchers said. “Thus, in nonobese Japanese men, impaired early insulin secretion might be an underlying mechanism of elevated 1-hour glucose levels during OGTT.”

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Most Read Articles
18 May 2020
Immobilization or disuse of the forearm leads to impairment in the ability of a protein-rich meal to promote positive muscle amino acid balance, which is aggravated by dietary lipid oversupply, suggests a study. Disuse also lowers postprandial forearm amino acid uptake, but this is not exacerbated under high-fat conditions.
18 May 2020
Glucagon-like peptide-1 receptor agonists (GLP-1RA) are more effective than basal insulin in the management of total (TC) and low-density lipoprotein cholesterol (LDL-C), reveals a recent study.
17 May 2020
Increased coffee consumption among regular drinkers is associated with higher estimated glomerular filtration rate and confers protection against the risk of chronic kidney disease stages G3–G5 and albuminuria, as shown in a study.
Jairia Dela Cruz, 16 May 2020
Excess weight, greater abdominal fat, inflammation and low physical performance can all contribute to insulin resistance in middle-age Singaporean women, and these variables explain why the condition is more common among women of Chinese than Malay and Indian ethnicities, a study has found.