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Hidradenitis suppurativa tied to higher diabetes mellitus prevalence

10 Feb 2018

A significant association exists between hidradenitis suppurativa and an increased prevalence of diabetes mellitus, according to a recent study.

A systematic review and meta-analysis was conducted, which included primary observational studies reporting on the prevalence of diabetes mellitus among patients with hidradenitis suppurativa in the PubMed, Embase, Cochrane Library, Lilacs and Scielo databases from 1947 to 13 June 2017.

For data analysis, the investigators used random effects model for pooled odds ratio (OR). Publication bias was assessed by using funnel plot and the Egger test.

A total of 14 studies (n=107,050 patients) were included in the systematic review and seven studies (n=104,373 patients) in the meta-analysis.

The meta-analysis revealed a 10.6-percent prevalence of diabetes mellitus in patients with hidradenitis suppurativa and 3.8-percent incidence in those without hidradenitis suppurativa. Compared with the general population, patients with hidradenitis suppurativa had nearly threefold times higher likelihood to develop diabetes mellitus (pooled OR, 2.78; 95 percent CI, 1.79‒4.31).

This study was limited by the quantity and quality of available data, according to the investigators.

In one study, researchers found that patients with hidradenitis suppurativa were at an increased risk for metabolic syndrome, a multifaceted disorder strongly associated with greater risk for development of cardiovascular disease. These patients had a 50.6-percent prevalence of metabolic syndrome, which was significantly higher than the 30.2-percent prevalence in the control group (p<0.001). [J Am Acad Dermatol 2014;70:699-703]

“Chronic inflammatory diseases have been associated with metabolic syndrome. Hidradenitis suppurativa is a chronic inflammatory skin disease with significant physical and emotional sequelae,” researchers noted.

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